2019
DOI: 10.7554/elife.47346
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Fog signaling has diverse roles in epithelial morphogenesis in insects

Abstract: The Drosophila Fog pathway represents one of the best-understood signaling cascades controlling epithelial morphogenesis. During gastrulation, Fog induces apical cell constrictions that drive the invagination of mesoderm and posterior gut primordia. The cellular mechanisms underlying primordia internalization vary greatly among insects and recent work has suggested that Fog signaling is specific to the fast mode of gastrulation found in some flies. On the contrary, here we show in the beetle Tribolium, whose d… Show more

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Cited by 30 publications
(41 citation statements)
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References 87 publications
(173 reference statements)
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“…2a) 12 . While it is in principle possible that leading cells are not excluded and converge to a multicellular rosette, such a rosette has not been observed during Tribolium serosa window closure 12,13,17 . Our cell tracking experiments showed that the initial number of approximately 75 leading cells progressively decreased to only 5-6 cells during final serosa closure (Fig.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…2a) 12 . While it is in principle possible that leading cells are not excluded and converge to a multicellular rosette, such a rosette has not been observed during Tribolium serosa window closure 12,13,17 . Our cell tracking experiments showed that the initial number of approximately 75 leading cells progressively decreased to only 5-6 cells during final serosa closure (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…More systematic probing of the mechanical properties of gastrulating Tribolium embryos will be required to understand the source of the forces acting on the serosa. We expect that the condensation of the adjoining embryonic primordium 13,14 , together with additional forces generated by the attachment of the blastoderm to the vitelline envelope 30 , the yolk 13 , active crawling of the serosa on the vitelline envelope 12 , and regulated changes in the shape and stiffness of the serosal cells 17,34,35 , may also contribute to the serosal epiboly.…”
Section: Discussionmentioning
confidence: 99%
“…The Fog signaling pathway represents one of the best-understood signaling cascades controlling epithelial morphogenesis (Manning and Rogers, 2014). Although best studied in Drosophila , the pathway components have also been identified in other insects, suggesting a more widely conserved role of Fog signaling in development (Urbansky et al ., 2016; Benton et al ., 2019). Further work needs to be done to fully understand the regulatory mechanisms underlying the trafficking of Fog and its receptor(s) during epithelial morphogenesis.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast to C. riparius, Fog signaling plays a role in mesoderm internalization for the flour beetle, Tribolium castaneum. In T. castaneum, the homologs of twi, cta, fog, and mist are expressed in the mesoderm, similar to Drosophila (Handel et al 2005;Benton et al 2019). Furthermore, fog depletion in T. castaneum delays mesoderm internalization and T. castaneum mesoderm cells undergo pulsatile contractions, similar to Drosophila (Benton et al 2019).…”
Section: Consequences Of Apical Constriction: Invagination Vs Ingresmentioning
confidence: 97%
“…In T. castaneum, the homologs of twi, cta, fog, and mist are expressed in the mesoderm, similar to Drosophila (Handel et al 2005;Benton et al 2019). Furthermore, fog depletion in T. castaneum delays mesoderm internalization and T. castaneum mesoderm cells undergo pulsatile contractions, similar to Drosophila (Benton et al 2019). Interestingly, Fog signaling in T. castaneum and several other insect species plays a role in cellularization, suggesting that this might be the ancestral function of the Fog pathway (Benton et al 2019).…”
Section: Consequences Of Apical Constriction: Invagination Vs Ingresmentioning
confidence: 97%