2020
DOI: 10.1534/genetics.119.301292
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The Physical Mechanisms ofDrosophilaGastrulation: Mesoderm and Endoderm Invagination

Abstract: A critical juncture in early development is the partitioning of cells that will adopt different fates into three germ layers: the ectoderm, the mesoderm, and the endoderm. This step is achieved through the internalization of specified cells from the outermost surface layer, through a process called gastrulation. In Drosophila, gastrulation is achieved through cell shape changes (i.e., apical constriction) that change tissue curvature and lead to the folding of a surface epithelium. Folding of embryonic tissue … Show more

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Cited by 53 publications
(56 citation statements)
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References 157 publications
(249 reference statements)
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“…The embryo undergoes gastrulation by invagination [ 64 ], which brings the three germ layers, the ectoderm, the somatic muscle forming mesoderm, and endoderm in juxtaposition with each other. This helps provide extrinsic signals to the developing mesoderm.…”
Section: Muscle Diversification—on the Road To Muscle Homeostasismentioning
confidence: 99%
“…The embryo undergoes gastrulation by invagination [ 64 ], which brings the three germ layers, the ectoderm, the somatic muscle forming mesoderm, and endoderm in juxtaposition with each other. This helps provide extrinsic signals to the developing mesoderm.…”
Section: Muscle Diversification—on the Road To Muscle Homeostasismentioning
confidence: 99%
“…Initially assembling into spot junctions distributed along the lateral furrow, the E-cad–catenin complex coalesces into unmatured adherens junctions at the typical subapical position only by the end of cellularization. During gastrulation, the epithelial epidermis undergoes stage and position-dependent morphogenetic movements, such as tissue invagination ( Leptin, 2005 ; Martin, 2020 ), folding ( Wang et al, 2012 ), convergent extension ( Kong et al, 2017 ; Paré and Zallen, 2020 ), compartmental boundaries formation ( Sharrock and Sanson, 2020 ), and dorsal closure ( Hayes and Solon, 2017 ; Kiehart et al, 2017 ) to name the most prominent ones.…”
Section: Drosophila Embryonic Epitheliummentioning
confidence: 99%
“…The selected live imaging approaches focus primarily on two developmental programs—gastrulation and neural crest cell development—that are established paradigms for investigating EMT during embryo development. First, gastrulation is a crucial stage of early animal development in which embryonic epithelial cells undergo EMT and migrate to form the three germ layers of cells, endoderm, mesoderm, and ectoderm, that give rise to all cell types in the body [ 22 , 23 ]. Second, neural crest cells undergo EMT to delaminate from the epithelium of the neural tube and migrate long distances in characteristic streams of cells that can include single cells and collective cell migration [ 24 ].…”
Section: Introductionmentioning
confidence: 99%
“…The Drosophila embryo begins as a large syncytium, and then undergoes cellularization to give rise to epithelial cells. During gastrulation, presumptive mesoderm cells undergo cell shape changes, internalization, EMT, and migration [ 22 ]. In this case, EMT is a long process, during which AJs remodel and gradually disassemble.…”
Section: Introductionmentioning
confidence: 99%