Folate and MMA predict cognitive impairment in elderly stroke survivors: A cross sectional study

Pascoe, Michaela C.; Lindén, Thomas

doi:10.1016/j.psychres.2016.06.008

Cited by 13 publications

(7 citation statements)

References 44 publications

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“…Famous hypothesis for mental disorders is 'homocysteine hypothesis' that excess homocysteine causes the development of psychiatric symptoms. Particularly, folate, vitamin B6, and vitamin B12 are involved in homocysteine metabolism, and low levels of the B vitamins and high levels of homocysteine were observed in subjects with MCI, dementia, and depression [ 9 17 18 19 47 48 ]. Suggested mechanisms underlying homocysteine action on brain function are impairments in cerebral vasculature and function of neurotransmitters, and increases in neurotoxicity and oxidative stress [ 40 49 50 ].…”

Section: Nutritional Factors Affecting Mental Healthmentioning

confidence: 99%

Nutritional Factors Affecting Mental Health

Lim

Kim

et al. 2016

Clin Nutr Res

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Dietary intake and nutritional status of individuals are important factors affecting mental health and the development of psychiatric disorders. Majority of scientific evidence relating to mental health focuses on depression, cognitive function, and dementia, and limited evidence is available about other psychiatric disorders including schizophrenia. As life span of human being is increasing, the more the prevalence of mental disorders is, the more attention rises. Lists of suggested nutritional components that may be beneficial for mental health are omega-3 fatty acids, phospholipids, cholesterol, niacin, folate, vitamin B6, and vitamin B12. Saturated fat and simple sugar are considered detrimental to cognitive function. Evidence on the effect of cholesterol is conflicting; however, in general, blood cholesterol levels are negatively associated with the risk of depression. Collectively, the aims of this review are to introduce known nutritional factors for mental health, and to discuss recent issues of the nutritional impact on cognitive function and healthy brain aging.

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Section: Nutritional Factors Affecting Mental Healthmentioning

confidence: 99%

Nutritional Factors Affecting Mental Health

Lim

Kim

et al. 2016

Clin Nutr Res

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“…High serum MMA is common in the elderly and negatively correlated with motor and cognitive performance (31). Increased MMA has also been confirmed to be associated with cognitive impairment in elderly stroke survivors (32). Some studies have concluded that the correlation between serum MMA and tHcy and cognitive impairment is stronger than VitB12 although the relationship between VitB12 and cognition is well known by researchers (33).…”

Section: Discussionmentioning

confidence: 99%

Association Between Methylmalonic Acid and Cognition: A Systematic Review and Meta-Analysis

Wang

Zhang²,

Shu³

et al. 2022

Front. Pediatr.

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BackgroundMethylmalonic acid (MMA) is an intermediate metabolite of human body. The content of MMA in the blood of healthy people is very low, and its concentration will increase in some diseases and elderly people. Recent studies have shown that MMA has a variety of biological functions. The correlation between MMA and cognition, one of the important functions of the nervous system, is still uncertain.ObjectiveMeta-analyses were performed to assess whether elevated MMA was associated with the risk of cognitive decline.Materials and MethodsCross-sectional studies, randomized controlled studies, and case-control studies on the relationship between MMA and cognition were obtained by searching PubMed, Web of Science, EMBASE, ProQuest, WANFANG MED ONLINE, China National Knowledge Infrastructure (CNKI) and Chongqing VIP until May 2022. Two researchers independently selected studies according to inclusion and exclusion criteria, evaluated study quality and extracted data. Meta-analyses were performed using Review Manager 5.4 software. The sensitivity analysis of meta-analysis was performed by One by one exclusion method.ResultsA total of 11 studies were included, including six cross-sectional studies, two randomized controlled studies, and three case-control studies, with a sample of 16,533 subjects. Meta-analysis showed that there was no significant difference in cognitive level between high-level MMA subjects and low-level MMA subjects in the general population [SMD = −2.19, 95% CI (−4.76 ∼ 0.38), Z = 1.67, P = 0.09]. In the population supplemented with VitB12, the increase of MMA level caused by VitB12 supplementation was not related to the change of cognition [SMD = 0.32, 95% CI (−0.19 ∼ 0.84) z = 1.22, P = 0.22]. There was also no significant difference in MMA levels between patients with dementia and the control group [WMD = 20.89, 95% CI (−5.13 ∼ 46.92), z = 1.57, P = 0.12].ConclusionIn the general population, whether VitB12 is supplemented or not, there is no correlation between the increase of MMA level and the decrease of cognitive level. In dementia diseases, the level of MMA did not change significantly. High levels of MMA may not be a risk factor for cognitive impairment. The exact relationship between MMA and cognition needs further research.Systematic Review Registration[https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021266310], identifier [CRD42021266310].

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“…Growth in the concentration of kynurenine metabolites and exhaustion of tryptophan is a marker of adverse prognosis of ischemic stroke. Low tryptophan level is associated with a significant cognitive deficit in Alzheimer's disease [25]. A similar study conducted with the participation of stroke patients showed a link between increased kynurenine to tryptophan ratio and the degree of severity of poststroke cognitive impairment [26].…”

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confidence: 89%

Molecular biomarkers of cognitive impairment in ischemic stroke

Yurevna¹,

Evgenevna²,

Mihaylovna³

et al. 2019

Medical news of the North Caucasus

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педиатрический медицинский университет, Российская ФедерацияAt the review systematize modern ideas about biomarkers of cognitive impairment in ischemic stroke were performed. The metabolic changes underlying the ischemic cascade were combined into three basic processes: excitotoxicity, oxidative stress, and inflammation. Studies of the possible relationship between key metabolites and mediators of acute ischemic stroke and the state of higher cortical functions are analyzed. The search for sensitive and specific biomarkers of cognitive impairment will make it possible to predict the rehabilitation potential and will promote the earliest possible start of cognitive rehabilitation measures. Besides, it will enable the development of modern methods of drug correction and prevention of vascular dementia.

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Folate and MMA predict cognitive impairment in elderly stroke survivors: A cross sectional study

Cited by 13 publications

References 44 publications

Nutritional Factors Affecting Mental Health

Nutritional Factors Affecting Mental Health

Association Between Methylmalonic Acid and Cognition: A Systematic Review and Meta-Analysis

Molecular biomarkers of cognitive impairment in ischemic stroke

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