Folate and Vitamin B‐12 Status Is Associated With Bone Mineral Density and Hip Strength of Postmenopausal <scp>Chinese‐Singaporean</scp> Women

Leek, Francesca; Wang, Nan Xin; Koh, Huann Rong; Roy, Nicole C.; Cameron‐Smith, David; Kruger, Marlena C.; Henry, Christiani Jeyakumar; Totman, John J.

doi:10.1002/jbm4.10399

Cited by 16 publications

(14 citation statements)

References 45 publications

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“…Vitamin K is known as a cofactor for the optimal mineralization of bone and is positively associated with BMD [ 11 ]. In addition, several epidemiologic studies found a significant relationship between high folate intake/concentrations and increased BMD or reduced fracture risk [ 7 , 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…Other critical nutrients for a vegan diet are long-chain n-3 fatty acids [ 10 ], vitamins (B12, A) [ 10 ], or minerals (zinc, selenium, iodine) [ 10 ], which are also related to bone health [ 8 ]. On the other hand, vegetarian and vegan diets provide important nutrients that protect bone, e.g., vitamin K [ 7 , 8 , 11 ] and folate [ 7 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Vegan Diet and Bone Health—Results from the Cross-Sectional RBVD Study

et al. 2021

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Scientific evidence suggests that a vegan diet might be associated with impaired bone health. Therefore, a cross-sectional study (n = 36 vegans, n = 36 omnivores) was used to investigate the associations of veganism with calcaneal quantitative ultrasound (QUS) measurements, along with the investigation of differences in the concentrations of nutrition- and bone-related biomarkers between vegans and omnivores. This study revealed lower levels in the QUS parameters in vegans compared to omnivores, e.g., broadband ultrasound attenuation (vegans: 111.8 ± 10.7 dB/MHz, omnivores: 118.0 ± 10.8 dB/MHz, p = 0.02). Vegans had lower levels of vitamin A, B2, lysine, zinc, selenoprotein P, n-3 fatty acids, urinary iodine, and calcium levels, while the concentrations of vitamin K1, folate, and glutamine were higher in vegans compared to omnivores. Applying a reduced rank regression, 12 out of the 28 biomarkers were identified to contribute most to bone health, i.e., lysine, urinary iodine, thyroid-stimulating hormone, selenoprotein P, vitamin A, leucine, α-klotho, n-3 fatty acids, urinary calcium/magnesium, vitamin B6, and FGF23. All QUS parameters increased across the tertiles of the pattern score. The study provides evidence of lower bone health in vegans compared to omnivores, additionally revealing a combination of nutrition-related biomarkers, which may contribute to bone health. Further studies are needed to confirm these findings.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vegan Diet and Bone Health—Results from the Cross-Sectional RBVD Study

et al. 2021

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“…The criterion for menopause is that menstruation has stopped for more than 12 months [11]. The diagnosis of T2DM is based on the standards of the American Diabetes Association [12], and the diagnosis criteria of osteoporosis refer to the diagnostic criteria established by the Chinese Society of Osteoporosis and Bone Mineral Diseases [13]. After diagnosis, the participants were divided into two groups.…”

Section: Methodsmentioning

confidence: 99%

Correlation of Serum Estradiol with Bone Mineral Density and Bone Metabolism in Patients of Postmenopausal Type 2 Diabetes Mellitus Complicated with Osteoporosis

Yang

2022

Horm Metab Res

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Type 2 diabetes mellitus (T2DM) complicated with osteoporosis, is a systemic metabolic disease that affects postmenopausal women. This disease is closely related to the lack of estrogen. This study aims to demonstrate the correlation between serum estradiol (E2) levels and osteoporosis, bone mineral density, and bone metabolism indicators in postmenopausal women with T2DM complicated with osteoporosis (T2DM-OP). 130 postmenopausal women with T2DM were divided into the T2DM group (n=62) and the T2DM-OP group (n=68) according to bone mineral density (BMD). In addition, 80 postmenopausal women with average blood glucose and bone density were selected as the healthy control group. We compare the serum levels of E2, bone metabolism indicators, and biochemistry indexes among the three groups of participants. Compared with the healthy control and T2DM groups, the BMD and serum level of E2 in T2DM-OP patients were significantly decreased, while the serum levels of bone alkaline phosphatase, type I procollagen amino-terminal propeptide, osteocalcin, and β-collagen C-terminal collagen cross-links were significantly increased. The serum levels of E2 in the postmenopausal T2DM-OP patients are positively correlated with BMD and negatively correlated with bone resorption indicators.

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“…Folate is essential for thymidine synthesis and thus for DNA formation and any cell division hence its role in the formation of red blood cells and healthy cell growth and function [67]. It is also an important nutrient involved in bone protection [69][70][71].…”

Section: Folatementioning

confidence: 99%

Is vegan diet advisable for children?

Kayode

Okumede

Alabi

et al. 2022

Bioactive Compounds in Health and Disease

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Vegan diet (VD) is a diet that consists of only plant based foods. This diet completely excludes all animal products; meat, fish, poultry and also food gotten from milk, oil and honey. Vegan diet differs from vegetarian diet, although they are similar; some vegetarian include egg (ovo vegetarians), milk from animals (lacto vegetarians) or fish (pescovegetarian) in their diet. VD is believed to be healthier than diets containing animal produce and generally have a higher diet quality than non-vegan diets. VD has many health benefits and may also reduce the risk of certain conditions such as hypertension, diabetes and cancer. However, these benefits seen in adults may not be the same case for toddlers and young children. Their diet directly affects their height, weight and also psychomotor and neurocognitive development. VD may not supply all the nutrients necessary for development and may lead to nutrient deficiency. Vegan children are at a risk of insufficient supply and deficiency of some critical nutrients such as protein, long chain fatty acids, cholesterol, iron, zinc, iodine, calcium, and vitamin A, B12 and D. Deficiency of these nutrients could lead to various developmental and sometimes irreversible disorders. Apart from nutrition, VD also seems to alter the metabolomics and gut microbiota constitution of a vegan. Overall VD may have health benefits for children if it is properly fortified and supplemented. VD in children will also have to be carefully monitored to ensure the diet is healthy, nutritious and promote healthy growth and development. Keywords: Children, Vegan diet, Nutrition, Metabolomics, Inborn errors of metabolism

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Folate and Vitamin B‐12 Status Is Associated With Bone Mineral Density and Hip Strength of Postmenopausal Chinese‐Singaporean Women

Cited by 16 publications

References 45 publications

Vegan Diet and Bone Health—Results from the Cross-Sectional RBVD Study

Vegan Diet and Bone Health—Results from the Cross-Sectional RBVD Study

Correlation of Serum Estradiol with Bone Mineral Density and Bone Metabolism in Patients of Postmenopausal Type 2 Diabetes Mellitus Complicated with Osteoporosis

Is vegan diet advisable for children?

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