Folate deficiency and aberrant expression of cell adhesion molecule 1 are potential indicators of prognosis in laryngeal squamous cell carcinoma

Abstract

The etiology of laryngeal squamous cell carcinoma (LSCC) has not yet been adequately examined. Therefore, the present study aimed to investigate the association between serum folate deficiency and abnormal expression of the cell adhesion molecule 1 (CADM1) protein in the progression of LSCC. Samples were collected from 60 patients with LSCC and 30 healthy people. Radioimmunoassays and immunohistochemical staining were performed to measure serum folate levels and CADM1 protein expression, respectively. The results demonstrated that CADM1 expression in LSCC specimens was significantly lower than in adjacent normal tissues (χ2=28.229, P<0.001), which was associated with histological differentiation and clinical stage (P=0.010 and 0.020, respectively). Levels of serum folate in patients with LSCC were significantly lower than those observed in healthy individuals (P=0.002). Furthermore, TSLCl expression and serum folate levels were positively correlated in LSCC (r=0.642, P=0.001). Thus, the present study determined that decreased CADM1 protein expression and low levels of serum folate were correlated with an increased severity of LSCC.

Comparison of salivary and serum homocysteine levels in oral squamous cell carcinoma

“…People who had received vitamin B12 in the previous six months, those with renal insufficiency, those with diseases that affect salivary homocysteine, including diabetes, Alzheimer's and Parkinson's disease, and osteoporosis, those with coronary artery disorders and venous thrombosis, and smokers were excluded from the study. 15,16 None of the patients were alcohol consumers.…”

The Relationship Between Serum Folate and Homocysteine with Head and Neck Cancer: A Systematic Review and Meta-analysis

“…Several studies have documented a significant correlation between the occurrence of HNSCC and decreased serum folate (9)(10)(11)(12)(13)(14)(15)(16), as well as increased serum Hcy levels (9,10,12,13,15,17,18). In a systematic review encompassing four studies, HNSCC patients exhibited significantly lower serum folate levels compared to controls (19).…”

Functional and Clinical Characteristics of Cell Adhesion Molecule CADM1 in Cancer

“…In addition, CADM1 mRNA and protein expression is associated with laryngeal squamous cell carcinoma cases (Lu et al, 2012). Considering clinical prognosis, lower CADM1 expression is associated with severe laryngeal squamous cell carcinoma (Chang et al, 2016). In esophageal squamous cell carcinoma, the OS (overall survival) and PFS (progression-free survival) of the CADM1 positive group was higher than those of the negative group, and CADM1 could have a potential role in prognosis (Zeng et al, 2016).…”