Folate-Functionalized Mesoporous Hollow SnO<sub>2</sub> Nanofibers as a Targeting Drug Carrier to Improve the Antitumor Effect of Paclitaxel for Liver Cancer Therapy

Lv, Huiling; Wu, Chao; Li, Xuan; Bai, Andi; Cao, Yue; Shang, Wenjing; Hu, Lili; Liu, Ying

doi:10.1155/2018/8526190

Cited by 17 publications

(11 citation statements)

References 41 publications

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“…For instance, SnO 2 NP could induce human HCT116 and A549 cells to produce ROS in vitro , which leads to cell death ( Tammina et al, 2017 ); besides, it is found that SnO 2 NP treatment can cause HepG2 cells to occur Morphological changes and cytotoxic effects ( Roopan et al, 2015 ); it is also demonstrated that SnO 2 NP can induce oxidative stress in MCF-7 cells, prompting the cells to synthesize ROS, increasing H 2 O 2 levels, triggering lipid peroxidation, reducing glutathione and antioxidant enzymes levels, and finally causing cell damage ( Ahamed et al, 2018 ); Moreover, Lv found that SnO 2 nanofibers can not only reduce the cell activity of hepatocellular carcinoma SMMC-7721 but also induce apoptosis. Western blot detection found that the expression of Caspase-3, the apoptosis-related protein, was increased ( Lv et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Stannic Oxide Nanoparticle Regulates Proliferation, Invasion, Apoptosis, and Oxidative Stress of Oral Cancer Cells

et al. 2020

Front. Bioeng. Biotechnol.

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Objective: To explore the effects of SnO 2 nanoparticles (NPs) on proliferation, invasion, apoptosis, and oxidative stress of oral cancer. Methods: SnO 2 NPs were prepared and characterized. Oral cancer cell lines CAL-27 and SCC-9 were cultured in vitro. We detected the effects of various concentrations of SnO 2 NPs (0, 5, 25, 50, 100, 200 µg/mL) on the proliferation of oral cancer cells, and observed the morphological changes, and measured the cells ability of migration, invasion and apoptosis condition, and the levels of oxidative stress were measured by detecting malondialdehyde (MDA) and reactive oxygen species (ROS). Besides, we also measured the changes of mRNA and protein levels of factors related to cell proliferation, migration, invasion, apoptosis, and oxidative stress. Results: SnO 2 NPs inhibited the proliferation of oral cancer cells in a concentrationdependent manner (all P < 0.05). And SnO 2 NPs treatment could reduce the migration and invasion ability of cells (all P < 0.05), induce apoptosis, and those effects were better when treated for 48 h than 24 h (all P < 0.05). And SnO 2 NPs could induce oxidative stress in cells (all P < 0.05). Besides, the concentrations of cyclin-D1, C-myc, matrix MMP-9, and MMP-2 in SnO 2 NPs treated group was decreased (all P < 0.05), and the expression levels of cleaved Caspase-3, cleaved Caspase-9, and Cytochrome C were increased (all P < 0.05). Conclusion: In the present study, we found that SnO 2 NPs could play a cytotoxic role in oral cancer cells, and inhibit cell proliferation, migration, and invasion, and induce oxidative stress and apoptosis, which suggests that SnO 2 NPs may have the effects of anti-oral cancer. However, a more in-depth study is needed to determine its roles.

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Section: Discussionmentioning

confidence: 99%

Stannic Oxide Nanoparticle Regulates Proliferation, Invasion, Apoptosis, and Oxidative Stress of Oral Cancer Cells

et al. 2020

Front. Bioeng. Biotechnol.

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“…The in vitro dissolution study results show that SFNFP exhibited an 8.34 times higher dissolution rate compared to naked Paclitaxel, over a period of 5 minutes. While the cumulative release rate of pure Paclitaxel was only 16.77 ± 2.00% after 1h, a high dissolution rate of 80.00 ± 2.64% was observed from SFNFP [63]. The release profiles of Paclitaxel from the SFNFP followed Noyes-Whitney’s drug release profiles.…”

Section: Applications Of Nanofibers In Therapeutics Deliverymentioning

confidence: 98%

Electrospinning Nanofibers for Therapeutics Delivery

et al. 2019

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The limitations of conventional therapeutic drugs necessitate the importance of developing novel therapeutics to treat diverse diseases. Conventional drugs have poor blood circulation time and are not stable or compatible with the biological system. Nanomaterials, with their exceptional structural properties, have gained significance as promising materials for the development of novel therapeutics. Nanofibers with unique physiochemical and biological properties have gained significant attention in the field of health care and biomedical research. The choice of a wide variety of materials for nanofiber fabrication, along with the release of therapeutic payload in sustained and controlled release patterns, make nanofibers an ideal material for drug delivery research. Electrospinning is the conventional method for fabricating nanofibers with different morphologies and is often used for the mass production of nanofibers. This review highlights the recent advancements in the use of nanofibers for the delivery of therapeutic drugs, nucleic acids and growth factors. A detailed mechanism for fabricating different types of nanofiber produced from electrospinning, and factors influencing nanofiber generation, are discussed. The insights from this review can provide a thorough understanding of the precise selection of materials used for fabricating nanofibers for specific therapeutic applications and also the importance of nanofibers for drug delivery applications.

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“…Nanoparticles are used directly and in nanofiber forms. Upon using nanoparticles with nanofibers, drug release time increases, and therefore makes it possible to load more drugs on both nanoparticles and nanofibers 167 . Fiber‐based DDSs use a variety of ionic, metallic, carbon, and paramagnetic nanoparticles and nanocarriers (virus, micelles, liposomes, and bacteria).…”

Section: Application Of Nanoparticles In Ddssmentioning

confidence: 99%

Altering the characterization of nanofibers by changing the electrospinning parameters and their application in tissue engineering, drug delivery, and gene delivery systems

Ghaderpour

Hoseinkhani

Yarani

et al. 2021

Polymers for Advanced Techs

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Nowadays, nanofibers have various applications in the field of medical biology including drug delivery systems (DDSs) and tissue engineering. Many methods have been developed to produce drug release polymers; the most important and applicable of which is known as electrospinning. In this method, the nanoscale and microscale fibers are used as the functional polymers in the DDSs. A variety of electrospinning methods can be used for delivery systems and tissue engineering. The nanofibers loaded with anticancer drugs have attracted a lot of attention in the last decade. Electrospun parameters include voltage, feed rate, rotary collector, pipette or needle hole diameter, the distance between nozzle tip to collector plate, viscosity and molecular weight of the polymer, surface tension, solubility of polymer, soluble electrical conductivity, dielectric constant, and evaporability of the solution; all could be manipulated to regulate the drug release rate in order via changing the diameter of the nanofibers. In addition to directly loading the drug on nanofibers, the nanoparticles are also used to improve the drug efficacy and reduce the required dose, especially in the case of harmful drugs. Depending on the need, various nanoparticles and nanocarriers are being applied along with the drug. Nanocarriers such as viruses, micelles, and liposomes function highly specific since they carry specific ligands on their surface. Magnetic nanoparticles also have a great therapeutic effect on cancer cells when exposed to heat and magnetic fields. Carbon nanoparticles, such as graphene and graphene oxide, due to their layering, can pass through the cell membrane and deliver the drug to the intracellular space.

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Folate-Functionalized Mesoporous Hollow SnO₂ Nanofibers as a Targeting Drug Carrier to Improve the Antitumor Effect of Paclitaxel for Liver Cancer Therapy

Cited by 17 publications

References 41 publications

Stannic Oxide Nanoparticle Regulates Proliferation, Invasion, Apoptosis, and Oxidative Stress of Oral Cancer Cells

Stannic Oxide Nanoparticle Regulates Proliferation, Invasion, Apoptosis, and Oxidative Stress of Oral Cancer Cells

Electrospinning Nanofibers for Therapeutics Delivery

Altering the characterization of nanofibers by changing the electrospinning parameters and their application in tissue engineering, drug delivery, and gene delivery systems

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Folate-Functionalized Mesoporous Hollow SnO2 Nanofibers as a Targeting Drug Carrier to Improve the Antitumor Effect of Paclitaxel for Liver Cancer Therapy

Cited by 17 publications

References 41 publications

Stannic Oxide Nanoparticle Regulates Proliferation, Invasion, Apoptosis, and Oxidative Stress of Oral Cancer Cells

Stannic Oxide Nanoparticle Regulates Proliferation, Invasion, Apoptosis, and Oxidative Stress of Oral Cancer Cells

Electrospinning Nanofibers for Therapeutics Delivery

Altering the characterization of nanofibers by changing the electrospinning parameters and their application in tissue engineering, drug delivery, and gene delivery systems

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Product

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Folate-Functionalized Mesoporous Hollow SnO₂ Nanofibers as a Targeting Drug Carrier to Improve the Antitumor Effect of Paclitaxel for Liver Cancer Therapy