Folate, homocysteine, interleukin-6, and tumor necrosis factor alfa levels, but not the methylenetetrahydrofolate reductase C677T polymorphism, are risk factors for schizophrenia

García-Miss, María del Rosario; Pérez-Mutul, José; López-Canul, B.; Solı́s-Rodrı́guez, Francisco; Puga-Machado, Luis; Oxté-Cabrera, Adrián; Gurubel-Maldonado, Jesús; Arankowsky‐Sandoval, Gloria

doi:10.1016/j.jpsychires.2009.10.011

Cited by 64 publications

(27 citation statements)

References 46 publications

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“…The roles of TNF-α in controlling neuronal excitability and metabolisms of glutamate, dopamine, and serotonin neurotransmitters make it an outstanding candidate for etiology and pathophysiology of schizophrenia (Tian et al, 2014). Alterations in serum TNF-α level in chronic schizophrenia patients have been reported previously, but with inconsistent results, being no different (Pedrini et al, 2012; Kunz et al, 2011), elevated (Lin et al, 1998; Naudin et al, 1997; Beumer et al, 2012; García-Miss et al, 2010; Luo et al, 2014) or reduced (Francesconi et al, 2011; Lv et al, 2014; Potvin et al, 2008), as compared with healthy control subjects. Nonetheless, these evidences implicate the role of TNF-α and TNF-α-related signaling pathways in the pathophysiology of schizophrenia.…”

Section: Discussionmentioning

confidence: 79%

Relationship of serum levels of TNF-α, IL-6 and IL-18 and schizophrenia-like symptoms in chronic ketamine abusers

Fan

Luo

Zhang

et al. 2015

Schizophrenia Research

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Objective Exposing to NMDAR receptor antagonists, such as ketamine, produces schizophrenia-like symptoms in humans and deteriorates symptoms in schizophrenia patients. Meanwhile, schizophrenia is associated with alterations of cytokines in the immune system. This study aims to examine the serum TNF-α, IL-6 and IL-18 levels in chronic human ketamine users as compared to healthy subjects. The correlations between the serum cytokines levels with the demographic, ketamine use characteristics and psychiatric symptoms were also assessed. Methods 155 subjects who fulfilled the criteria of ketamine dependence and 80 healthy control subjects were recruited. Serum TNF-α, IL-6 and IL-18 levels were measured using an enzyme-linked immunosorbent assay (ELISA). The psychiatric symptoms of the ketamine abusers were assessed using the Positive and Negative Syndrome Scale (PANSS). Results Serum IL-6 and IL-18 levels were significantly higher, while serum TNF-α level was significantly lower among ketamine users than among healthy controls (p < 0.05). Serum TNF-α levels showed a significant negative association with PANSS total score (r = −0.210, p < 0.01) and negative subscore (r = −0.300, p < 0.01). No significant association was found between PANSS score and serum levels of IL-6 and IL-18. Conclusions Serum levels of TNF-α, IL-6 and IL-18 were altered in chronic ketamine abusers which may play a role in schizophrenia-like symptoms in chronic ketamine abusers.

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Section: Discussionmentioning

confidence: 79%

Relationship of serum levels of TNF-α, IL-6 and IL-18 and schizophrenia-like symptoms in chronic ketamine abusers

Fan

Luo

Zhang

et al. 2015

Schizophrenia Research

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“…The patient samples consisted of persons meeting the DSM-IV-TR (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision) criteria for paranoid type of schizophrenia (APA). The diagnoses had been assigned based on a Structured Clinical Interview for DSM-IV Axis I Disorders-Clinical Version (First et al 1997) by the two independent experienced psychiatrists. Other available resources such as clinical course, medical records and family history information were also used.…”

Section: Patients and Controlsmentioning

confidence: 99%

Functional Polymorphism in the Interleukin-6 and Interleukin-10 Genes in Patients with Paranoid Schizophrenia —A Case-Control Study

et al. 2010

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Schizophrenia is a multifactorial disease with changes in immunological system. Such changes are the result of cytokine-level disturbances connected with cytokine gene polymorphisms. However, research about cytokine gene polymorphisms in schizophrenia has been surprisingly limited and ambiguous. The aim of the study was to identify whether polymorphisms of interleukin (IL)-6 and IL-10 are risk factors for the development of paranoid schizophrenia in case-control study. IL-6 (-174G/C; rs 1800795) and IL-10 (-1082G/A; rs 1800896) promoter polymorphisms in patients with paranoid schizophrenia and healthy individuals were genotyped using polymerase chain reaction-restriction fragment length polymorphism method. Differences in IL-6 and IL-10 promoter haplotypes may play an important role in determining the transcription level for IL-6 and IL-10 genes in schizophrenic patients. The presence of allele C at position -174 of IL-6 promoter sequence may correlate with increasing risk of paranoid schizophrenia in the Polish population, but research on a broadened group of people is needed. The presence of allele G at position -1082 of IL-10 promoter sequence correlates with increasing risk of paranoid schizophrenia in the Polish population. The coexistence of genotype GG at position -1082 of IL-10 promoter sequence and genotype GC at position -174 of IL-6 promoter sequence correlates with increasing risk of paranoid schizophrenia in the Polish population.

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“…La esquizofrenia paranoide fue el subtipo más representativo en la población estudiada con un 65%, como lo reporta la OMS (2013) a nivel mundial. La falta de predominio del homocigoto T en la población estudiada coincide con los resultados obtenidos en México por García-Miss et al (2010), Kang et al (2010), Kim et al (2011), Saetre et al (2011) y Yu et al (2004, en el resto del mundo, quienes no encontraron una predominancia entre la esquizofrenia y el homocigoto T. Dato contrario a lo que reportan estudios como el de Allen et al (2008), Gilbody et al (2007), Kempisty et al (2007), Roffman et al (2008) y Zhang et al (2013, quienes refieren un riesgo de presentación de la enfermedad de hasta 2.75.…”

Section: Discussionunclassified

“…Respecto a la esquizofrenia, sólo existe un estudio en México, mas no esclarece la asociación reportada en otros países. García-Miss et al (2010) no demostraron que el polimorfismo pudiera ser un factor de riesgo para la esquizofrenia, aun cuando el homocigoto T estuvo presente en el 30% de los casos. Tampoco se estudió la probable relación registrada en otros estudios (Roffman et al, 2008), entre la predominancia sintomatológica y el polimorfismo MTHFR C677T.…”

Section: S S N 0 1 8 8 -6 2 6unclassified

“…En los índices consultados para los países de Centroamérica y Sudamérica no se registran estudios sobre la asociación estadística de estas dos variables. En México, sólo una investigación ha reportado datos acerca de esta posible relación, donde no se encontró asociación entre la esquizofrenia y el polimorfismo C677T en 105 pacientes con este diagnósti-co, pero sí se halló una asociación significativa entre el homocigoto T y los altos niveles de homocisteína (García-Miss et al, 2010). Sin embargo, tal como lo sugieren los autores del presente estudio, se requiere profundizar sobre este tema en población mexicana para esclarecer su probable implicación con el trastorno (tabla 1).…”

Section: Introductionunclassified

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Association of MTHFR C677T polymorphism with symptomatic predominance in a sample of schizophrenic patients from Jalisco, Mexico

Jaramillo¹,

Cobián

García

et al. 2016

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56Asociación del polimorfismo MTHFR C677T con la predominancia sintomatológica en una muestra de pacientes con esquizofrenia de Jalisco, México RESUMENLa esquizofrenia es un trastorno mental grave, recientemente asociado a distintas variantes genéticas como el polimorfismo de la enzima Metilenotetrahidrofolato reductasa (MTHFR) C677T. El objetivo fue evaluar la asociación estadística del polimorfismo MTHFR C677T, con la predominancia sintomatológica en una muestra de pacientes con esquizofrenia de Jalisco, México. Se realizó un estudio descriptivo, transversal, con enfoque retrospectivo, donde se analizaron 49 pacientes, quienes fueron clasificados por su predominancia sintomatológica con la escala de los Síndromes Positivo y Negativo (PANSS, por sus siglas en inglés), para determinar su asociación con algún genotipo del polimorfismo MTHFR C677T. La muestra estudiada estuvo en equilibrio de Hardy-Weinberg. La frecuencia del alelo T fue de 51% y para el homocigoto T de 31%. No hubo diferencia estadística significativa entre los genotipos y la predominancia sintomatológica: CC/CT (p = 0.72), CC/TT (p = 0.84), CT/ TT (p = 0.88). El homocigoto T y los síntomas positivos fueron más frecuentes en mujeres. El heterocigoto CT y los síntomas negativos fueron más prevalentes en el género masculino. La variante termolábil del gen MTHFR (homocigoto T) en pacientes con esquizofrenia no es un factor predisponente para presentar alguna predominancia sintomatológica. ABSTRACTSchizophrenia is a severe mental illness that has been recently associated with some genetic mutations as MTHFR C677T polymorphism. The objective was to evaluate the statistic association of MTHFR C677T polymorphism with symptomatic predominance in a sample of schizophrenic patients from Jalisco, Mexico. The study has a descriptive, retrospective, cross-sectional design, which analyzed a total of 49 patients classified by their symptomatic predominance with the Positive and Negative Syndrome Scale (PANSS) scale to determine their association with any polymorphism of MTHFR C677T polymorphism. The sample was in Hardy-Weinberg equilibrium. The allele frequency for T was 51% and for homozygous TT 31%. No statistic difference between genotypes and symptomatic predominance: CC/ CT (p = 0.72), CC/TT (p = 0.84), CT/TT (p = 0.88). The homozygous T and positive symptoms were more frequent in women. In contrast, the heterozygous CT and negative symptoms had more prevalence in men. The thermolabile variant of MTHFR gene (homozygous T) in schizophrenic patients, is not related to present symptomatic predominance. * Instituto Jalisciense de Salud Mental (Salme), Secretaría de Salud, Jalisco, México, Universidad de Guadalajara. Prados de la Higuera núm. 1045, col. Prados de la Cruz, Tonalá, Jalisco, México, C.P. 45410. Tel. (33) 37920534. Correo electrónico: rickaudiffred@hotmail.com ** Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara. *** Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS). Palabras clave...

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Folate, homocysteine, interleukin-6, and tumor necrosis factor alfa levels, but not the methylenetetrahydrofolate reductase C677T polymorphism, are risk factors for schizophrenia

Cited by 64 publications

References 46 publications

Relationship of serum levels of TNF-α, IL-6 and IL-18 and schizophrenia-like symptoms in chronic ketamine abusers

Relationship of serum levels of TNF-α, IL-6 and IL-18 and schizophrenia-like symptoms in chronic ketamine abusers

Functional Polymorphism in the Interleukin-6 and Interleukin-10 Genes in Patients with Paranoid Schizophrenia —A Case-Control Study

Association of MTHFR C677T polymorphism with symptomatic predominance in a sample of schizophrenic patients from Jalisco, Mexico

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