Folate Levels in Patients Hospitalized with Coronavirus Disease 2019

Meisel, Eshcar; Efros, Orly; Bleier, Jonathan; Halevi, Tal Beit; Segal, Gad; Rahav, Galia; Leibowitz, Avshalom; Grossman, Ehud

doi:10.3390/nu13030812

Cited by 23 publications

(14 citation statements)

References 42 publications

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“…Our study indicates a positive correlation between B9 and IgG levels in female patients. Decreased folate value is highly prevalent in patients hospitalized with COVID-19 infection [ 67 ]. Zinc plays a crucial role in antibody production via the alterations of the function and number of various immune cells in inflammatory conditions [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

The association between micronutrients and the SARS-CoV-2-specific antibodies in convalescent patients

et al. 2022

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Background Various micronutrients play key roles in the immune responses to viral infection, antibody synthesis, and susceptibility to infection. This study aimed to investigate the role of micronutrients on the immune responses following SARS-CoV-2 infection. Methods To evaluate humoral immunity following SARS-CoV-2 infection, the levels of SARS-CoV-2-specific IgM and IgG, as well as the concentrations of different micronutrients, were determined in 36 convalescent COVID-19 patients 60 days after infection. Furthermore, the correlation between biochemical and hematological parameters, clinical features, and the changes in adiposity with SARS-CoV-2 antibodies was evaluated. Results Serum IgM and IgG antibodies were detected in 38.8% and 83.3% of recovered patients after 60 days of COVID-19 infection, respectively. The values of SARS-CoV-2-specific IgG were negatively correlated with the number of the platelet. Moreover, the values of SARS-CoV-2-specific IgM were positively correlated with LDH and the vitamin B12 concentration. Furthermore, a gender-specific association of SARS-CoV-2-specific IgG and IgM with vitamins D as well as with B9 and zinc was observed. A significant negative correlation was observed between the values of IgG with vitamin D in male participants and a positive correlation was detected between IgG values and B9 in female participants. Moreover, IgM levels with serum zinc values in females were negatively correlated. Conclusion Our study suggests the potential role of micronutrients in gender-specific humoral immunity following SARS-CoV-2 infection. Further studies are required with a greater sample of subjects to substantiate the validity and robustness of our findings.

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Section: Discussionmentioning

confidence: 99%

The association between micronutrients and the SARS-CoV-2-specific antibodies in convalescent patients

et al. 2022

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“…1 showed the flow chart of related literature search and selection process. A total of twenty-three articles with 573,928 COVID-19 patients were eligibly included in this quantitative meta-analysis [ [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] ]. The characteristics of the eligible studies are summarized in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

Significant association between anemia and higher risk for COVID-19 mortality: A meta-analysis of adjusted effect estimates

Wang

Li²,

Hu³

et al. 2022

The American Journal of Emergency Medicine

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“…39 Decreased levels of serum folate are common among inpatients with COVID-19. 40 Multiple strategies enable SARS-CoV-2 to evade the innate immunity; these include low cytosine-phosphateguanosine levels in the genome and suppression of IFN-α/β production at the earliest stage of infection. 41,42 According to a classic theory of traditional Chinese medicine, the lung and large intestine are "interior-exteriorly" related.…”

Section: Discussionmentioning

confidence: 99%

Combined Network Pharmacology, Molecular Docking, and Experimental Verification Approach to Investigate the Potential Mechanisms of Polydatin Against COVID-19

Wang

Qin

Zhai

2022

Natural Product Communications

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Background: Coronavirus disease 2019 (COVID-19) has posed a serious threat to human health and there is an urgent need for drug development. In this study, we explored the potential mechanisms underlying the efficacy of polydatin against COVID-19. Methods: A combined approach of network pharmacology, molecular docking, and experimental verification were employed in this study. Potential targets of polydatin for treating COVID-19 were obtained from multiple drug and disease databases. Protein–protein interaction and enrichment analyses were performed to predict the potential mechanism of action of polydatin against COVID-19. The binding potential of polydatin and key targets was evaluated through molecular docking. Furthermore, experimental methods including flow cytometry and luciferase assay were used to validate the results of computational analyses. Results: The main diseases identified as polydatin targets included metabolic diseases, lung diseases, inflammation, infectious diseases, and tumors. Polydatin may be used to treat COVID-19 through interventions that alter the immune and inflammatory responses, including IL-17 signaling pathway, T-cell activation, cytokines and inflammatory response, lipopolysaccharide-mediated signaling pathway, as well as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) innate immunity evasion and cell-specific immune response. Polydatin can potentially bind to the target proteins related to COVID-19, such as SARS-CoV-2 Mpro, RdRp, and human angiotensin-converting enzyme 2 (ACE2), while directly exerting its regulatory or therapeutic functions. The experimental results showed that polydatin decreased the infectivity of the SARS-CoV-2 spike pseudovirus in HEK293T-ACE2 cells. Accordingly, polydatin may retard the entry of SARS-CoV-2 into cells by competitively binding to human ACE2. Conclusion: The potential targets and signaling pathways of polydatin against COVID-19 were preliminarily identified. The findings may benefit the development and application of polydatin as a treatment for COVID-19.

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Folate Levels in Patients Hospitalized with Coronavirus Disease 2019

Cited by 23 publications

References 42 publications

The association between micronutrients and the SARS-CoV-2-specific antibodies in convalescent patients

The association between micronutrients and the SARS-CoV-2-specific antibodies in convalescent patients

Significant association between anemia and higher risk for COVID-19 mortality: A meta-analysis of adjusted effect estimates

Combined Network Pharmacology, Molecular Docking, and Experimental Verification Approach to Investigate the Potential Mechanisms of Polydatin Against COVID-19

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