Folate metabolism and problem behaviour in mentally handicapped epileptics

Deb, Shoumitro; Cowie, Valerie; Richens, A.

doi:10.1111/j.1365-2788.1987.tb01352.x

Cited by 6 publications

(6 citation statements)

References 12 publications

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“…One study 47 collected information on challenging behaviour from parents’ and carers’ reports and one study 51 used its own questionnaire, for which no validation data are provided. Among the studies that used validated questionnaires, five 12 , 36 , 48 , 58 , 59 used challenging behaviour items from the Disability Assessment Schedule (DAS) 60 and another three 40 , 61 , 62 used DAS challenging behaviour items from the Profile of Abilities and Adjustment schedule (PAA) 61 , 63 . Three studies 37 , 39 , 45 used the Adaptive Behaviour Scale Part II (ABS-II), 64 which scores maladaptive behaviours.…”

Section: Resultsmentioning

confidence: 99%

“…Of the 34 papers, 19 included participants with and without epilepsy, as their authors compared the rates of challenging behaviour in these two groups to assess an association between challenging behaviour and epilepsy (Table 1). Of these, nine studies [36][37][38][39][40][41][42][43][44] had equal numbers of participants in both groups and the groups were matched on various demographic variables. The rest (n = 10) 12,45-53 were prevalence studies of challenging behaviour in adults with intellectual disabilities that included a number of participants with epilepsy (around 22% of the cohort).…”

Section: Included Studiesmentioning

confidence: 99%

“…Blickwedel et al, 2019 53 Deb et al, 1987 36 Deb et al, 2001 12 Deb, 1997 40 Espie et al, 1989 37 Espie et al, 2003 46 Fitzgerald et al, 2011 50 Gillies et al, 1989 38 Matson et al, 1999 41 Matthews et al, 2008 43 McGrother et al, 2006 48 O'Dwyer et al, 2018 51 Pawar & Akuffo, 2008 49 Prasher, 1995 45 Smith & Matson, 2010a 44 Turkistani Blickwedel et al, 2019 53 Deb et al, 1987 36 Deb et al, 2001 12 Deb, 1997 40 Espie et al, 1989 37 Espie et al, 2003 46 Fitzgerald et al, 2011 50 Gillies et al, 1989 38 Matson et al, 1999 41 Matthews et al, 2008 43 McGrother et al, 2006 48 O'Dwyer et al, 2018 51 Pawar & Akuffo, 2008 49 Prasher, 1995 45 Smith & Matson, 2010a 44 Turkistani, 2004 47 Total (95% Cl)…”

Section: Quality Controlmentioning

confidence: 99%

“…Another problem is that none of these specific behavioural types was defined using any standardised criteria (such as the Modified Overt Aggression Scale for rating aggression) 15,82 but were based on single-item scoring. Blickwedel et al, 2019 53 Chung & cassidy, 2001 42 Collacott, 1993 39 Deb, 1997 40 Deb et al, 1987 36 Deb et al, 2001 12 Espie et al, 1989 37 Espie et al, 2003 46 Fitzgerald et al, 2011 50 Folch et al, 2018 52 Gillies et al, 1989 38 Matson et al, 1999 41 Matthews et al, 2008 43 McGrother et al, 2006 48 O'Dwyer et al, 2018 51 Pawar & Akuffo, 2008 49 Prasher, 1995 45 Smith & Matson, 2010a 44 Turkistani, 2004 47 Random sequence generation (selection bias)…”

Section: Types Of Challenging Behaviourmentioning

confidence: 99%

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Association between epilepsy and challenging behaviour in adults with intellectual disabilities: systematic review and meta-analysis

Brizard¹,

Limbu

2020

BJPsych open

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Background Previous systematic reviews showed no significant association between epilepsy and challenging behaviours in adults with intellectual disabilities. Aims To identify whether there is an association between epilepsy and challenging behaviour in adults with intellectual disabilities by carrying out a systematic review of published data. PROSPERO registration number: CRD42020178092. Method We searched five databases and hand-searched six journals. Two authors independently screened titles, abstracts and full articles using a standardised eligibility checklist. Several meta-analyses were carried out. Results The narrative analysis of data from 34 included articles (14 168 adults with intellectual disabilities, 4781 of whom also had epilepsy) showed no significant association between epilepsy and challenging behaviour. Meta-analysis was possible on data from 16 controlled studies. This showed no significant intergroup difference but after sensitivity analysis meta-analysis of 10 studies showed a significantly higher rate of overall challenging behaviour in the epilepsy group (effect size: 0.16) compared with the non-epilepsy group. Aggression and self-injurious behaviour both showed a statistically significant higher rate in the epilepsy group, with very small effect sizes (0.16 and 0.28 respectively). No significant intergroup difference was observed in the rate of stereotypy. Conclusions The findings are contradictory and must be interpreted with caution because of the difficulty in pooling data from varied studies, which is likely to introduce confounding. Where significant differences were found, effect sizes are small and may not be clinically significant, and there are major methodological flaws in the included studies, which should be addressed in future large-scale properly controlled studies.

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Section: Resultsmentioning

confidence: 99%

Section: Included Studiesmentioning

confidence: 99%

Section: Quality Controlmentioning

confidence: 99%

Section: Types Of Challenging Behaviourmentioning

confidence: 99%

See 2 more Smart Citations

Association between epilepsy and challenging behaviour in adults with intellectual disabilities: systematic review and meta-analysis

Brizard¹,

Limbu

2020

BJPsych open

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“…Because there are many different types of epilepsy, a nutritional intervention that is helpful for one patient may not be beneficial for another. Some studies did not specify the types of epilepsy being treated, so it is difficult to generalize results (Christiansen and Rodbro, 1974;Clarke et al, 1979;Coker, 1992;Cornelissen et al, 1993;Crowell and Roach, 1983;Davis et al, 1975;Deb et al, 1987;Djukic, 2007;Dupont and Tanaka, 1985;Furlanut et al, 1978;Gibberd et al, 1981;Gospe, 2006). Nevertheless, natural approaches to the treatment of epilepsy show promise and should be considered as part of the overall treatment of epilepsy.…”

Section: Discussionmentioning

confidence: 99%

Role of certain nutritional supplements and biological regulators in the epilepsy

Asif¹

2013

TANG [HUMANITAS MEDICINE]

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Certain dietary contents, biological supplements might influence the occurrence or treatment of epilepsy. Some studies have found that the supplementation with individual nutrients reduced seizure frequency or improved other aspects of health in patients with epilepsy. Potentially beneficial dietary interventions include treating blood glucose dysregulations. Identifying and avoiding allergenic foods, and avoiding suspected triggering agents such as alcohol, aspartame, and monosodium glutamate. The Atkins diet (very low in carbohydrates) is a less restrictive type diet that may be effective in some cases. Nutrients that may reduce seizure frequency include vitamin B6, magnesium, vitamin E, manganese, taurine, dimethylglycine, and omega-3 fatty acids. Administration of thiamine may improve cognitive function in patients with epilepsy. Supplementation with folic acid, vitamin B6, biotin, vitamin D, and L-carnitine may be needed to prevent or treat deficiencies resulting from the use of anticonvulsant drugs. Vitamin K1 has been recommended near the end of pregnancy for women taking anticonvulsants. Melatonin may reduce seizure frequency in some cases, and progesterone may be useful for women with cyclic exacerbations of seizures. In most cases, nutritional therapy is not a substitute for anticonvulsant medications. However, in selected cases, depending on the effectiveness of the interventions, dosage reductions or discontinuation of medications may be possible. However, nutrient supplementation may be necessary to prevent or reverse the effects of certain deficiencies that frequently result from the use of antiepileptic drugs.

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Prevalence, patterns, service needs, and assessment of neuropsychiatric disorders among people with epilepsy in residential care: Validation of the Neuropsychiatric Inventory as a caregiver-rated measure of neuropsychiatric functioning in epilepsy

Krishnamoorthy

Trimble

2008

Epilepsy & Behavior

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Folate metabolism and problem behaviour in mentally handicapped epileptics

Cited by 6 publications

References 12 publications

Association between epilepsy and challenging behaviour in adults with intellectual disabilities: systematic review and meta-analysis

Association between epilepsy and challenging behaviour in adults with intellectual disabilities: systematic review and meta-analysis

Role of certain nutritional supplements and biological regulators in the epilepsy

Prevalence, patterns, service needs, and assessment of neuropsychiatric disorders among people with epilepsy in residential care: Validation of the Neuropsychiatric Inventory as a caregiver-rated measure of neuropsychiatric functioning in epilepsy

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