Folate targeted coated SPIONs as efficient tool for MRI

Scialabba, Cinzia; Puleio, Roberto; Peddis, Davide; Varvaro, G.; Calandra, Pietro; Cassata, Giovanni; Cicero, Luca; Licciardi, Mariano; Giammona, Gaetano

doi:10.1007/s12274-017-1540-4

Cited by 52 publications

(34 citation statements)

References 36 publications

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“…[34][35][36] However, to the best of our knowledge, there was no report on crosslinked reducible polydopamine coated magnetic nanoparticles in theranostic system, although the dopamine moiety has been widely utilized for surface modication of inorganic nanoparticles. [37][38][39][40][41][42] Herein, in this article our object is to design and fabricate the biostable, biocompatible, and reducible polydopamine coated magnetic nanoparticles (SPIONs@PDA) that can achieve both MRI diagnosis and anticancer drug delivery. The shell of the magnetic nanoparticle was a crosslinked reducible polydopamine (PDA) synthesized with N,N-bis(acrylate) cystamine (BACy), dopamine methacrylamide (DMA), and polyethylene glycol (PEG) methyl ether methacrylate, where BACy served as crosslinker, PEG provided colloidal stability, and DOPA moiety as anchor to immobilize SPIONs.…”

Section: Introductionmentioning

confidence: 99%

SPIONs/DOX loaded polymer nanoparticles for MRI detection and efficient cell targeting drug delivery

et al. 2017

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Section: Introductionmentioning

confidence: 99%

SPIONs/DOX loaded polymer nanoparticles for MRI detection and efficient cell targeting drug delivery

et al. 2017

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“…By using cross-linking reagents EDC and NHS, folic acid was covalently immobilized onto amine-functionalized OPCNs-PEG 33 . Typically, 0.2 nM FA was added into OPCNs-PEG solution (20.0 mL, 0.1 mM) and reacted at room temperature for 12 h under magnetic stirring.…”

Section: Methodsmentioning

confidence: 99%

Octopod PtCu Nanoframe for Dual-Modal Imaging-Guided Synergistic Photothermal Radiotherapy

Liang

et al. 2018

Theranostics

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Heavy atom nanoparticles have high X-ray absorption capacity and near infrared (NIR) photothermal conversion efficiency, which could be used as radio-sensitizers. We hypothesized that concave PtCu octopod nanoframes (OPCNs) would be an efficient nanoplatform for synergistic radio-photothermal tumor ablation.Methods: In this study, we newly exploited a folic acid-receptor (FR) mediated photothermal radiotherapy nanoagent base on OPCNs. OPCNs were synthesized with a hydrothermal method and then modified with polyethylene glycol (PEG) and folic acid (FA). A series of physical and chemical characterizations, cytotoxicity, targeting potential, endocytosis mechanism, biodistribution, systematic toxicological evaluation, pharmacokinetics, applications of OPCNs-PEG-FA for in vitro and in vivo infrared thermal imaging (ITI)/photoacoustic imaging (PAI) dual-modal imaging and synergistic photothermal radiotherapy against tumor were carried out.Results: The OPCNs-PEG-FA demonstrated good biocompatibility, strong NIR absorption and X-ray radio-sensitization, which enabling it to track and visualize tumor in vivo via ITI/PAI dual-modal imaging. Moreover, the as-synthesized OPCNs-PEG-FA exhibited remarkable photothermal therapy (PTT) and radiotherapy (RT) synergistic tumor inhibition when treated with NIR laser and X-ray.Conclusion: A novel multifunctional theranostic nanoplatform based on OPCNs was designed and developed for dual-modal image-guided synergistic tumor photothermal radiotherapy.

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“…Folic acid was chosen as active targeting agent, since it has been widely demonstrated his capability to bind, with high affinity, FA receptors overexpressed in several human carcinomas such as ovary, breast, colon, lung, brain, and endometrium cancers. [36] [37] Whereas PEG 2000 was selected because it is a discrete high mobile macromolecule that generates large volume exclusion that limits unspecific protein adsorption in vivo and proven able to allow specific recognition of targeting agents introduced as end-chain. [38] The alkyne-terminated PEG-Fol was exploited to functionalize both faces of GO-N 3 by the click reaction between azides of GO-N 3 and alkyne end chain of Fol-PEG-CC, while the amine-teminated PEG was introduced at the GO perimeter by the coupling reaction between carboxyl groups of GO-N 3 and the amine function of the PEG chains.…”

Section: Synthesis Of Folate-peg-4-pentynoic Acid Derivative (Fol-pegmentioning

confidence: 99%

Folic acid-functionalized graphene oxide nanosheets via plasma etching as a platform to combine NIR anticancer phototherapy and targeted drug delivery

Mauro

Scialabba

Agnello

et al. 2020

Materials Science and Engineering: C

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PEGylated graphene oxide (GO) has shown potential as NIR converting agent to produce local heat useful in breast cancer therapy, since its suitable photothermal conversion, high stability in physiological fluids, biocompatibility and huge specific surface. GO is an appealing nanomaterial for potential clinical applications combining drug delivery and photothermal therapy in a single nanodevice capable of specifically targeting breast cancer cells. However, native GO sheets have large dimensions (0.5-5 m) such that tumor accumulation after a systemic administration is usually precluded. Herein, we report a step-by-step synthesis of folic acid-functionalized PEGylated GO, henceforth named GO-PEG-Fol, with small size and narrow size distribution (~30±5 nm), and the ability of efficiently converting NIR light into heat. GO-PEG-Fol consists of a nano-GO sheet, obtained by fragmentation of GO by means of non-equilibrium plasma etching, fully functionalized with folic acid-terminated PEG 2000 chains through amidic coupling and azide-alkyne click cycloaddition, which we showed as active targeting agents to selectively recognize breast cancer cells such as MCF7 and MDA-MB-231. The GO-PEG-Fol incorporated a high amount of doxorubicin hydrochloride (Doxo) (> 33%) and behaves as NIR-light-activated heater capable of triggering sudden Doxo delivery inside cancer cells and localized hyperthermia, thus provoking efficient breast cancer death. The cytotoxic effect was found to be selective for breast cancer cells, being the IC 50 up to 12 times lower than that observed for healthy fibroblasts. This work established plasma etching as a cost-effective strategy to get functionalized nano-GO with a smart combination of properties such as small size, good photothermal efficiency and targeted cytotoxic effect, which make it a promising candidate as photothermal agent for the treatment of breast cancer.

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Folate targeted coated SPIONs as efficient tool for MRI

Cited by 52 publications

References 36 publications

SPIONs/DOX loaded polymer nanoparticles for MRI detection and efficient cell targeting drug delivery

SPIONs/DOX loaded polymer nanoparticles for MRI detection and efficient cell targeting drug delivery

Octopod PtCu Nanoframe for Dual-Modal Imaging-Guided Synergistic Photothermal Radiotherapy

Folic acid-functionalized graphene oxide nanosheets via plasma etching as a platform to combine NIR anticancer phototherapy and targeted drug delivery

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