Folate-targeted nanomicelles containing silibinin as an active drug delivery system for liver cancer therapy

Ghalehkhondabi, Vahab; Soleymani, Meysam; Fazlali, Alireza

doi:10.1016/j.jddst.2020.102157

Cited by 42 publications

(17 citation statements)

References 51 publications

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“…The release exponent values were n = 0.01 for NiTPP, n = 0.06 for CoTPP, and n = 0.11 for MnClTPP, and less than 0.43, indicating Fickian diffusion of MeP [92]. These results corresponded to previously reported data describing lipophilic substance release mechanisms [93][94][95][96]. Figure 9 shows the IC50 values of MeP-NPs and AA combination against HeLa, MCF-7, and SK-OV-3 cells.…”

Section: In Vitro Drug Releasesupporting

confidence: 89%

Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles

Mollaeva

Yabbarov

Sokół

et al. 2021

IJMS

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The selection of technological parameters for nanoparticle formulation represents a complicated development phase. Therefore, the statistical analysis based on Box–Behnken methodology is widely used to optimize technological processes, including poly(lactic-co-glycolic acid) nanoparticle formulation. In this study, we applied a two-level three-factor design to optimize the preparation of nanoparticles loaded with cobalt (CoTPP), manganese (MnClTPP), and nickel (NiTPP) metalloporphyrins (MeP). The resulting nanoparticles were examined by dynamic light scattering, X-ray diffraction, Fourier transform infrared spectroscopy, MTT test, and hemolytic activity assay. The optimized model of nanoparticle formulation was validated, and the obtained nanoparticles possessed a spherical shape and physicochemical characteristics enabling them to deliver MeP in cancer cells. In vitro hemolysis assay revealed high safety of the formulated MeP-loaded nanoparticles. The MeP release demonstrated a biphasic profile and release mechanism via Fick diffusion, according to release exponent values. Formulated MeP-loaded nanoparticles revealed significant antitumor activity and ability to generate reactive oxygen species. MnClTPP- and CoTPP-nanoparticles specifically accumulated in tissues, preventing wide tissue distribution caused by long-term circulation of the hydrophobic drug. Our results suggest that MnClTPP- and CoTPP-nanoparticles represent the greatest potential for utilization in in anticancer therapy due to their effectiveness and safety.

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Section: In Vitro Drug Releasesupporting

confidence: 89%

Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles

Mollaeva

Yabbarov

Sokół

et al. 2021

IJMS

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“…Moreover, the exponent ( n ) in the Korsmeyer–Peppas model reveals the mechanism of drug release from the carrier 45,46 . For spherical carriers, n ≤ 0.43 indicates the Fickian diffusion mechanism, and 0.43 ≤ n ≤ 0.85 represents the non‐Fickian diffusion mechanism 45,46 . To determine the best model for describing the release mechanism of 5‐FU from P(NIPAAm‐co‐AAc)@mSiO 2 @Fe 3 O 4 nanocomposites, the obtained drug release profiles at temperatures of 37°C and 45°C were fitted to above mentioned models, and correlation coefficients ( R 2 ) and k values are presented at Table 1.…”

Section: Resultsmentioning

confidence: 99%

Design of thermosensitive polymer‐coated magnetic mesoporous silica nanocomposites with a core‐shell‐shell structure as a magnetic/temperature dual‐responsive drug delivery vehicle

Asgari

Soleymani

Miri

et al. 2021

Polymers for Advanced Techs

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A stimuli-responsive nanocomposite with a core-shell-shell structure consisting of iron oxide (Fe 3 O 4 ) nanoparticles as core, mesoporous silica as middle shell, and poly(Nisopropyl acrylamide-co-acrylic acid) (P[NIPAAm-co-AAc]) as an exterior shell with thermo-responsivity properties was synthesized to be used as a magnetic/temperature responsive drug delivery system. The structure, morphology, and size of P(NIPAAm-co-AAc)-coated mesoporous silica embedded magnetite nanoparticles (P(NIPAAm-co-AAc) @mSiO 2 @Fe 3 O 4 ) were characterized by XRD, FTIR, and TEM analyses. Also, the heating ability of mesoporous silica-coated Fe 3 O 4 nanoparticles, and P(NIPAAm-co-AAc) @mSiO 2 @Fe 3 O 4 nanocomposites was investigated under the exposure of an alternating magnetic field (AMF). The results indicated that the prepared nanocomposites could generate enough heat for hyperthermia applications. Moreover, the magnetic/temperatureresponsive drug release behavior of P(NIPAAm-co-AAc)@mSiO 2 @Fe 3 O 4 nanocomposites loaded with fluorouracil (5-FU) was studied under the exposure of the AMF (frequency = 120 kHz, and amplitude = 22 kA m À1 ), as well as two different temperatures (37 C and 45 C). The results showed that only 7.8% of the drug could be released after 20 h at 37 C (below the LCST of the copolymer). In contrast, by increasing the temperature of release medium up to 45 C (above the LCST of the copolymer), the amount of released drug was increased up to 47%. Moreover, by exposing the prepared nanocomposite to a safe AMF, a burst release of drug was observed, indicating the excellent responsivity of the carrier to an external magnetic field. These results proved that the obtained nanocomposite has a great performance to be used as a magnetic/temperature-sensitive drug carrier for advanced drug delivery applications.

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“…Several studies have used folic acid as a targeting agent in HCC, as shown below (Table 5). Folic acid [262] Pluronic F127 nanomicelles Silibinin…”

Section: Porf-htrail and Doxorubicinmentioning

confidence: 99%

Nanomedicine in Hepatocellular Carcinoma: A New Frontier in Targeted Cancer Treatment

2021

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Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death and is associated with a dismal median survival of 2–9 months. The fundamental limitations and ineffectiveness of current HCC treatments have led to the development of a vast range of nanotechnologies with the goal of improving the safety and efficacy of treatment for HCC. Although remarkable success has been achieved in nanomedicine research, there are unique considerations such as molecular heterogeneity and concomitant liver dysfunction that complicate the translation of nanotheranostics in HCC. This review highlights the progress, challenges, and targeting opportunities in HCC nanomedicine based on the growing literature in recent years.

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Folate-targeted nanomicelles containing silibinin as an active drug delivery system for liver cancer therapy

Cited by 42 publications

References 51 publications

Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles

Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles

Design of thermosensitive polymer‐coated magnetic mesoporous silica nanocomposites with a core‐shell‐shell structure as a magnetic/temperature dual‐responsive drug delivery vehicle

Nanomedicine in Hepatocellular Carcinoma: A New Frontier in Targeted Cancer Treatment

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