Folgen am harnbereitenden und harnableitenden System während Cyclophosphamid-Therapie<sup>1</sup>

Hj, Spechter; Km, Bauer; Mueller, Oliver; Traut, Herbert F.

doi:10.1055/s-0028-1113357

Cited by 17 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Published data on the incidence of bladder toxicity associated with pelvic irradiation and cyclophosphamide in combination are scanty in adults and are not available for children. Spechter et al 13 hematuria in patients who received pelvic irradiation and cyclophosphamide; six of these cases were fatal. Accinelli' noted bladder toxicity in nine patients of a n unstated denominator who received the two agents in combination.…”

Section: Discussionmentioning

confidence: 99%

Urinary-bladder toxicity following pelvic irradiation and simultaneous cyclophosphamide therapy

Jayalakshmamma

Pinkel

1976

Cancer

View full text Add to dashboard Cite

The frequency and severity of urinary-bladder toxicity were determined retrospectively in a large series of childhood cancer patients treated with either pelvic irradiation and simultaneous cyclophosphamide or cylclophosphamide with extrapelvic irradiation. Of 50 patients who received the first combination, 17 (34%) developed urinary-bladder toxicity. Eight of the 17 had transient hematuria and dysuria with complete clearing clinically after cessation of treatment; nine had chronic or intermittent hematuria which persisted after treatment was stopped and often resulted in demonstrable fibrosis and telangiectasia of the bladder. By contrast, of 60 children who received cyclophosphamide and radiotherapy outside the pelvic region, only five (8%) developed hematuria and in all instances it was transient. This comparative study demonstrates a significantly increased frequency and severity of urinary-bladder toxicity in cancer patients receiving pelvic irradiation with simultaneous cyclophosphamide.

show abstract

Section: Discussionmentioning

confidence: 99%

Urinary-bladder toxicity following pelvic irradiation and simultaneous cyclophosphamide therapy

Jayalakshmamma

Pinkel

1976

Cancer

View full text Add to dashboard Cite

show abstract

“…Urological complications due to its administration are well documented following the initial reports of transient cystitis by Coggins, Randin and Eisman (1959). As well as haemorrhagic cystitis which may be fatal (Spechter et al, 1965), widespread interstitial fibrosis may follow long-term administration (Johnson and Meadows, 1961 ;Marsh et al, 1971). Damage to the urinary tract caused by cyclophosphamide is due to direct contact between urothelium and toxic metabolites of cyclophosphamide excreted in the urine (Phillips et al, 1961).…”

mentioning

confidence: 99%

The Effect of N-Acetyl Cysteine on Cyclophosphamide Cystitis

Tolley¹

1977

British Journal of Urology

View full text Add to dashboard Cite

show abstract

Hemorrhagic cystitis and cytomegalic inclusions in the bladder associated with cyclophosphamide therapy

Goldman

Warner

1970

Cancer

View full text Add to dashboard Cite

A case of severe hemorrhagic cystitis resulting from cyclophosphamide administration is presented. This complication is of import because it may lead to fatal hemorrhage if the etiology is unrecognized. The lesion appears to result from direct contact with urinary metabolites of the drug, although its lack of universal occurrence may indicate associated genetic or constitutional factors. Prompt discontinuation of the drug and conservative measures usually alleviate symptoms, but cystostomy with tamponade or urinary diversion may be required in cases of persistent bleeding. The resemblance of cyclophosphamide cystitis to changes produced by irradiation is noted. Although the major alterations occur within the lamina propria, atypical epithelial changes may be confused with carcinoma. A unique finding included the presence of cytomegalovirus inclusions in the bladder. It is possible that bladder damage was potentiated by this infection or that the injured bladder offered a site of preferential localization for the virus.

show abstract

Folgen am harnbereitenden und harnableitenden System während Cyclophosphamid-Therapie¹

Cited by 17 publications

References 0 publications

Urinary-bladder toxicity following pelvic irradiation and simultaneous cyclophosphamide therapy

Urinary-bladder toxicity following pelvic irradiation and simultaneous cyclophosphamide therapy

The Effect of N-Acetyl Cysteine on Cyclophosphamide Cystitis

Hemorrhagic cystitis and cytomegalic inclusions in the bladder associated with cyclophosphamide therapy

Contact Info

Product

Resources

About

Folgen am harnbereitenden und harnableitenden System während Cyclophosphamid-Therapie1

Cited by 17 publications

References 0 publications

Urinary-bladder toxicity following pelvic irradiation and simultaneous cyclophosphamide therapy

Urinary-bladder toxicity following pelvic irradiation and simultaneous cyclophosphamide therapy

The Effect of N-Acetyl Cysteine on Cyclophosphamide Cystitis

Hemorrhagic cystitis and cytomegalic inclusions in the bladder associated with cyclophosphamide therapy

Contact Info

Product

Resources

About

Folgen am harnbereitenden und harnableitenden System während Cyclophosphamid-Therapie¹