2023
DOI: 10.1016/j.jnutbio.2022.109209
|View full text |Cite
|
Sign up to set email alerts
|

Folic acid ameliorates synaptic impairment following cerebral ischemia/reperfusion injury via inhibiting excessive activation of NMDA receptors

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
8
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 14 publications
(9 citation statements)
references
References 33 publications
1
8
0
Order By: Relevance
“…Our study findings showed a significant negative correlation between folate levels and depressive symptoms. This result is similar to that of another study, [ 28 ] which found that depressed patients had significantly lower folate levels than those without depression and had lower folate intake compared to non-depressed patients. Furthermore, depressed patients with low folate levels were less sensitive to antidepressant treatment and were more likely to relapse.…”
Section: Discussionsupporting
confidence: 91%
“…Our study findings showed a significant negative correlation between folate levels and depressive symptoms. This result is similar to that of another study, [ 28 ] which found that depressed patients had significantly lower folate levels than those without depression and had lower folate intake compared to non-depressed patients. Furthermore, depressed patients with low folate levels were less sensitive to antidepressant treatment and were more likely to relapse.…”
Section: Discussionsupporting
confidence: 91%
“…[48] GLuN1/GLuN2A/GLuN2B Cells/Rat Reduced synapse-associated proteins and Ca 2+ Amelioration of synaptic damage after cerebral ischemia/reperfusion injury by inhibition of NMDA receptor hyperactivation. [49] GluN2A/B Mice GluN2A excitotoxicity was enhanced and GluN2B excitotoxicity was attenuated.…”
Section: Nmdar Micementioning
confidence: 99%
“…Moreover, supplementation of folic acid, a type of vitamin B essential for nervous system development and function, holds promise in stroke prevention and as a potential treatment to ameliorate ischemic injury-induced cognitive decline. Folic acid supplementation may achieve this by inhibiting excitotoxicity, as evidenced by the downregulation of NMDAR expression [ 73 ].…”
Section: Antioxidant Bioactive Molecules Against Ischemic Strokementioning
confidence: 99%