Folic acid and zinc inhibit angiogenesis in chicken chorioallontoic membrane model via angiogenic factor genes

Abstract

We aimed to analyze the possible roles of FA and Zn on angiogenesis in vivo culture condition. CAM study revealed that FA and Zn decreased the vessel formation on CAM model. FGF1

Assessment of the Antiangiogenic and Anti-Inflammatory Properties of a Maslinic Acid Derivative and its Potentiation using Zinc Chloride

“…After the application on the angiogenic chorioallantoic membrane, the combination between EM2 and ZnCl 2 , especially that with 5% ZnCl 2, induced normal development of the CAM vessels, with signs of reparative potential and no proinflammatory or proangiogenic effects. ZnCl 2 alone reduced the number and branching of new forming vessels, as indicated by Güran et al through the inhibition of fibroblast growth factor 2 (FGF2) [40], but there were signs of vessel fragility. Thus, the association of the two agents could be beneficial for rapid wound healing exceptionally with less scar formation, without angiogenic stimulation [41].…”

Cell viability in sh-sy5y neuroblastoma cells in folic acid application by using jack-stat pathway

“…FA was obtained from I.E.Ulagay AS Company. FA was diluted in physiologic serum in 1μM, 5μM, 10μM concentrations (19,21).…”

“…XTT/MTT assays are used for finding the cell proliferation ratios. For cell viability, trypan blue assay is the most common form (18,19). Gene expression is the process by which genetic instructions…”