Folic acid conjugated poly (Amidoamine) dendrimer grafted magnetic chitosan as a smart drug delivery platform for doxorubicin: In-vitro drug release and cytotoxicity studies

Soltany, Parva; Miralinaghi, Mahsasadat; Pajoum Shariati, Farshid

doi:10.1016/j.ijbiomac.2023.127564

Cited by 15 publications

(1 citation statement)

References 49 publications

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“…There is intense interest in dendrimers as delivery vehicles, especially for anti-cancer, anti-neurodegenerative, and anti-inflammation drugs [ 73 , 74 , 75 , 76 ], with the most important role of dendrimers in these systems being the efficient transport of drugs to the site of action. The almost infinite possibilities for dendrimer functionalization mean that compounds such as antibodies [ 77 , 78 ], folic acid [ 79 ], amino acids [ 80 , 81 ], sugar groups [ 82 , 83 ], or other specific ligands can be attached to their surface so that these nanosystems can target specific cells and tissues ( Figure 5 ) [ 84 ]. For instance, these dendrimers could be designed to target cells with specific receptors or other substances secreted specifically by a given tumor type.…”

Section: In Vivo Use Of Dendrimersmentioning

confidence: 99%

In Vivo Applications of Dendrimers: A Step toward the Future of Nanoparticle-Mediated Therapeutics

Sztandera,

Rodríguez-García,

Ceña

2024

Pharmaceutics

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Over the last few years, the development of nanotechnology has allowed for the synthesis of many different nanostructures with controlled sizes, shapes, and chemical properties, with dendrimers being the best-characterized of them. In this review, we present a succinct view of the structure and the synthetic procedures used for dendrimer synthesis, as well as the cellular uptake mechanisms used by these nanoparticles to gain access to the cell. In addition, the manuscript reviews the reported in vivo applications of dendrimers as drug carriers for drugs used in the treatment of cancer, neurodegenerative diseases, infections, and ocular diseases. The dendrimer-based formulations that have reached different phases of clinical trials, including safety and pharmacokinetic studies, or as delivery agents for therapeutic compounds are also presented. The continuous development of nanotechnology which makes it possible to produce increasingly sophisticated and complex dendrimers indicates that this fascinating family of nanoparticles has a wide potential in the pharmaceutical industry, especially for applications in drug delivery systems, and that the number of dendrimer-based compounds entering clinical trials will markedly increase during the coming years.

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Section: In Vivo Use Of Dendrimersmentioning

confidence: 99%

In Vivo Applications of Dendrimers: A Step toward the Future of Nanoparticle-Mediated Therapeutics

Sztandera,

Rodríguez-García,

Ceña

2024

Pharmaceutics

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Dual pH and Ca²⁺‐Responsive PEG‐Modified Pillar[5]arene‐Based Supramolecular Nanodrug Delivery System: Excellent Cargo Encapsulation and Minimal Drug Toxicity

Shao,

Duan,

Huang

et al. 2024

Chemistry A European J

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Chemotherapy is one of the most employed strategies in clinical treatment of cancer. However, reducing medication adverse effects and improving the biological activity remains a significant issue for chemotherapy. We developed a pH and Ca2+‐responsive pillar[5]arene‐based supramolecular nanodrug delivery system (NDDS) WP5⊃EV@DOX to address the aforementioned challenges. The formation of this NDDS began with the spontaneous formation of supramolecular nanodrug carrier WP5⊃EV in water from PEG‐modified pillar[5]arene and the bipyridilium salt derivative EV through simple host‐guest interaction. Then the antitumor drug doxorubicin DOX was efficiently loaded with a high encapsulation rate of 84.6%. Cytotoxicity results indicated that the constructed nanoplatform not only reduced DOX toxicity and side effects on normal cell (293T), but also significantly enhanced the antitumor activity on cancer cell (HepG2). Moreover, in vivo experiments showed that WP5⊃EV@DOX had a longer half‐life and higher bioavailability in the blood of mice compared to the nake drug DOX, with increases to 212% and 179%, respectively. Therefore, WP5⊃EV@DOX has great potential in tumor therapy and provides a new idea for host‐guest drug delivery system.

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Fluorinated PAMAM-Arginine Carrier Prodrugs for pH-Sensitive Sustained Ibuprofen Delivery

Romani,

Sponchioni,

Volonterio

2024

Pharm Res

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Objective The development of an efficient, multifunctional drug delivery system overcoming different obstacles generally associated with drug formulations, including the poor accumulation of the active principle in the target site and its sustained release for prolonged time. Methods Our study proposes the development of a fluorinated poly(amidoamine) (PAMAM) carrier prodrug combining drug release boosted in alkaline environments with a possible implementation in 19F MRI applications. In particular, we functionalized the terminal primary amines of PAMAM G2 and G4 through an ad hoc designed fluorinated ibuprofen-arginine Michael acceptor to obtain multifunctional ibuprofen-PAMAM-Arg conjugates. Results These carriers demonstrated pH-dependent and sustained ibuprofen release for more than 5 days. This advantage was observed in both weak alkaline and physiological buffer solutions, allowing to overcome the limits associated to the burst release from similar fluorinated Arg-PAMAM dendrimers with ibuprofen physically encapsulated. Conclusion These findings, coupled to the high biocompatibility of the system, suggest a potential synergistic biomedical application of our conjugates, serving as vehicles for drug delivery and as 19F magnetic resonance imaging contrast agents.

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Folic acid conjugated poly (Amidoamine) dendrimer grafted magnetic chitosan as a smart drug delivery platform for doxorubicin: In-vitro drug release and cytotoxicity studies

Cited by 15 publications

References 49 publications

In Vivo Applications of Dendrimers: A Step toward the Future of Nanoparticle-Mediated Therapeutics

In Vivo Applications of Dendrimers: A Step toward the Future of Nanoparticle-Mediated Therapeutics

Dual pH and Ca²⁺‐Responsive PEG‐Modified Pillar[5]arene‐Based Supramolecular Nanodrug Delivery System: Excellent Cargo Encapsulation and Minimal Drug Toxicity

Fluorinated PAMAM-Arginine Carrier Prodrugs for pH-Sensitive Sustained Ibuprofen Delivery

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Folic acid conjugated poly (Amidoamine) dendrimer grafted magnetic chitosan as a smart drug delivery platform for doxorubicin: In-vitro drug release and cytotoxicity studies

Cited by 15 publications

References 49 publications

In Vivo Applications of Dendrimers: A Step toward the Future of Nanoparticle-Mediated Therapeutics

In Vivo Applications of Dendrimers: A Step toward the Future of Nanoparticle-Mediated Therapeutics

Dual pH and Ca2+‐Responsive PEG‐Modified Pillar[5]arene‐Based Supramolecular Nanodrug Delivery System: Excellent Cargo Encapsulation and Minimal Drug Toxicity

Fluorinated PAMAM-Arginine Carrier Prodrugs for pH-Sensitive Sustained Ibuprofen Delivery

Contact Info

Product

Resources

About

Dual pH and Ca²⁺‐Responsive PEG‐Modified Pillar[5]arene‐Based Supramolecular Nanodrug Delivery System: Excellent Cargo Encapsulation and Minimal Drug Toxicity