Folic acid fortification and cancer risk

Folic Acid in Obstetric Practice: A Review

“…31 Although the bulk of the evidence to date favors a good safety profile for folic acid supplements, the present scientific consensus on the association of folic acid with colon cancer appears to be divided. Many early epidemiological studies demonstrated a protective effect of folic acid supplements against colorectal and other organ malignancies, while some more recent studies have had conflicting results [32][33][34][35][36][37][38][39] with some investigators arguing for and others against folic acid fortification.…”

Fruit, Vegetables, and Folate: Cultivating the Evidence for Cancer Prevention

“…22 Recently, this has led to calls to reconsider programs of mandatory folic acid fortification of the food supply despite its established benefit for the prevention of neural tube defects. 23 …”