Folic‐Acid‐Functionalized Magnetic Nanoparticles as Green and Magnetic Recyclable Catalyst for the Synthesis of 4‐Aryl‐NH‐1,2,3‐triazoles in a Green Media

Abstract

A useful, robust, and cheap procedure was obtained for the synthesis of 4‐aryl‐NH‐1,2,3‐triazoles via aromatic aldehydes, nitromethane and choline azide in the presence of folic acid immobilized magnetic nanoparticle with good yields. The magnetic catalyst is easily synthesized and can be recycled at least five times with no significant loss in activity. In addition, the choline azide is used as a reagent and green solvent.

[DDQM][TFSI]: a room temperature ionic liquid as an active electrode material for supercapacitor devices and a catalyst for rapid synthesis of 4-aryl-NH-1,2,3-triazoles under microwave irradiation

“…Based on the observations from Table S2 (ESI†) and literature reports, 22 a plausible mechanism for [DDQM][TFSI]/DMSO is proposed (Scheme 1). Nitrostyrene was produced from aldehydes and nitroalkanes in the very first step.…”

Solvent‐Free Choline Derivative Synthesis as a Powerful Organic Synthesis Medium

“…A urea‐activated aromatic aldehyde forms an electrophilic center at its carbonyl carbon in an initial step in the synthesis of 1,2, 3‐triazoles. A nitrostyrene intermediate is formed from nitro‐methane and acetate combined with an activated aldehyde.The next step involves the cycloaddition of benzyl azide to produce the intermediate (H) [35b] . The elimination process occurs when the urea (H) intermediate reacts with counterions (Scheme 1).…”

Copper(I)–creatine complex on magnetic nanoparticles as a green catalyst for N‐ and O‐arylation in deep eutectic solvent

“…The XRD pattern of is indicative of a cubic structure of Fe 3 O 4 (2 θ = 35°, 41°, 51°, 64°, 67° and 75°). These peaks are matched to (220), (311), (400), (422), (511) and (440) lattice planes of cubic magnetite, respectively (JCPDS 19‐629) . These results indicate that Fe 3 O 4 @creatine‐Cu(I) had been successfully synthesized.…”