2022
DOI: 10.3389/fendo.2021.798866
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Follicle-Stimulating Hormone Induces Lipid Droplets via Gαi/o and β-Arrestin in an Endometrial Cancer Cell Line

Abstract: Follicle-stimulating hormone (FSH) and its G protein-coupled receptor, FSHR, represents a paradigm for receptor signaling systems that activate multiple and complex pathways. Classically, FSHR activates Gαs to increase intracellular levels of cAMP, but its ability to activate other G proteins, and β-arrestin-mediated signaling is well documented in many different cell systems. The pleiotropic signal capacity of FSHR offers a mechanism for how FSH drives multiple and dynamic downstream functions in both gonadal… Show more

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Cited by 4 publications
(2 citation statements)
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“…Follicle-stimulating hormone (FSH) is a gonadotropin secreted by the anterior pituitary gland, which functions by binding its receptor. The FSH receptor (FSHR), which is a member of the Class A/Rhodopsin subfamily of the G protein-coupled receptors (GPCRs), mediates the regulatory function of FSH [2]. For several years, the role of FSH was thought to be confined to gonadal tissues.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Follicle-stimulating hormone (FSH) is a gonadotropin secreted by the anterior pituitary gland, which functions by binding its receptor. The FSH receptor (FSHR), which is a member of the Class A/Rhodopsin subfamily of the G protein-coupled receptors (GPCRs), mediates the regulatory function of FSH [2]. For several years, the role of FSH was thought to be confined to gonadal tissues.…”
Section: Introductionmentioning
confidence: 99%
“…For several years, the role of FSH was thought to be confined to gonadal tissues. However, in recent times, researchers have paid increasing attention to its extra-gonadal roles, such as the regulation of lipid synthesis [2], metabolic syndrome [3], and, especially, the promotion of tumor development and progression.…”
Section: Introductionmentioning
confidence: 99%