Follicular Lymphoblastoma (Giant Lymph Follice Hyperplasia of Lymph Nodes and Spleen

Rheumatoid lymphadenopathy.

“…Still more rarely the appearances resemble lymphosarcoma or Hodgkin's disease. Some workers have defined histological factors which allow differentiation of simple follicular hyperplasia from giant follicular lymphoma (Cruickshank, 1958;Baggenstoss and Heck, 1940). In none of the 35 patients who attended Westminster Hospital with giant follicular lymphoma was there any suggestion that they were suffering from rheumatoid arthritis.…”

Value and limitations of fine-needle aspiration cytology in diagnosis and classification of lymphomas: A review

“…Once upon a time, nonspecific reactive follicular hyperplasia cases were frequently diagnosed as giant follicular lymphoblastomata, although some authors attempted to differentiate the two. 24,25 In the 1950s, Rappaport et al 26 enlisted those useful architectural and cytological criteria which favored a diagnosis of follicular lymphoma or follicular hyperplasia. Effacement of nodular architecture (and even distribution of nodules throughout the cortex and medulla), slight to moderate variation in size of (neoplastic) nodules, capsular and pericapsular tissue infiltration, and condensation of reticulin at the periphery of the follicles were the architectural features which favored a diagnosis of lymphomas.…”