Follicular lymphoid hyperplasia of the palate: Case report and literature review

Fine needle aspiration cytology of lymphoproliferative lesions of the oral cavity

“…Moreover, certain specific entities, such as plasmablastic lymphoma, an acquired immunodeficiency syndrome (AIDS)‐associated high‐grade NHL, have a high incidence in the oral cavity . Finally, benign entities, such as plasmacellular granuloma and FRLH, may arise in the oral cavity, further widening the spectrum of lymphoid oral swellings or masses.…”

Benign Lymphoid Hyperplasia of the Tongue Base Causing Upper Airway Obstruction

“…This entity was first described in 1973 by Adkins. and has since been primarily reported in the skin, breasts, gastrointestinal tract, lungs, and nasopharynx [2]. The majority of existing head and neck reports are of hyperplasia in the oral cavity, namely, of the mucosa overlying the hard palate, and are limited to the dental and pathology literature [3].…”

“…The etiology is poorly understood, although some authors have postulated a relationship with chronic irritation (i.e., reflux, poorly fitting dentures, etc.) or a reactive lymphoid proliferation to an unknown antigenic stimulation [2]. While an association with bacterial infection has not been clearly identified, one aggressive case of FLH has been linked to the presence of Epstein-Barr virus, causing clonal arrangement (expansion) in the local tissue DNA [4].…”

“…Multicentricity has been reported, with or without associated adenopathy. Clinical and laboratory investigations are routinely negative [2]. …”

Unusual Manifestations of Oral Follicular Lymphoid Hyperplasia Mimicking Oral Lichen Planus

“…Occasionally, the lesions may be multifocal, and the patients may have bilateral involvement. Usually, the lesion is soft and either colored or non-colored [3].…”