Follicular Lymphoma With Full Remission of Leukemic Phase

Anday, George J.

doi:10.1001/archinte.1956.00250230125014

Cited by 9 publications

(1 citation statement)

References 8 publications

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“…Twelve such patients had been treated with radiotherapy of the spleen (6,8,10,20), two patients with splenectomy (5, lo), and seven patients with low-dose chemotherapy (5,6,8,9,22) before entering remission. Six patients achieved their remission more than one year afier the cessation of therapy (5,6,9,18,20); another developed without treatment a transition of the leukaemia into a non-leukaemic solid lymphoma (9), and one entered remission without any therapy (2). All these cases have been referred to as "spontaneous" remissions (2, 3, 5, 6, 8-10, 18, 20).…”

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Haematological Remission of Leukaemic Polymorphic Immunocytoma Following Splenectomy

Juliusson

Öst

Biberfeld

et al. 1986

Acta Pathologica Microbiologica Scandinavica Series A :Patholog

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remission of leukaemic polymorphic immunocytoma following splenectomy. Case report with longitudinal immunological and cytogenetic studies. Acta path. microbiol. immunol. scand. Sect. A, 94: 133-139, 1986, A 56-year old man with a Rai stage IV B-cell chronic lymphocytic leukaemia (polymorphic immunocytoma according to the Kiel classification) of pK-phenotype with a clonal chromosomal abnormality in cells from peripheral blood, bone marrow, and spleen is reported on. Following splenectomy (without further therapy) the blood lymphocytosis gradually decreased to normal and the patient entered a remission, assigned 42 months after splenectomy by immunological and cytogenetic studies that revealed no cells of clonal origin in blood or bone marrow. Utilizing cellular markers of clonality, we thus confirm that haematological remissions may follow splenectomy. A subsequently developed orbital lymphoma (without leukaemia) consisted of tumor cells derived from the initial leukaemia cell clone as indicated by their immune and cytogenetic phenotype. The case report is discussed in relation to previous reports on "spontaneous" remissions of lymphoid leukaemias.

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confidence: 99%

Haematological Remission of Leukaemic Polymorphic Immunocytoma Following Splenectomy

Juliusson

Öst

Biberfeld

et al. 1986

Acta Pathologica Microbiologica Scandinavica Series A :Patholog

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Spontaneous remission of leukemic lymphoproliferative disease

Han

Sokal

1971

Cancer

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Spontaneous remission was observed in 4 of approximately 400 patients with chronic lymphocytic leukemia or malignant lymphoma with leukemic manifestations. Findings prior to spontaneous remission in these patients included generalized lymphadenopathy and splenomegaly. In one patient, the remission followed an acute (presumably viral) infection. Relapse of disease after spontaneous remission, characterized by lymphadenopathy and tissue infiltration only, without lymphocytosis or bone marrow involvement, was seen in one patient with chronic lymphocytic leukemia and one with leukemic lymphosarcoma. Seven well‐documented cases of spontaneous remission in leukemic lymphoproliferative disease were found in a survey of the literature. The patterns of normalization of the peripheral blood count seen in the pooled cases included both rapid declines of lymphocyte counts, consistent with active destruction of leukemic cells, and very slow decreases which suggested that the mechanism of remission was cessation of production of leukemic cells, with their subsequent disappearance at a rate consistent with their known long life span. Only one death from lymphoproliferative disease is recorded among these pooled cases.

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Spontaneous regression in non-Hodgkin's lymphoma

Gattiker

Wiltshaw

Galton

1980

Cancer

104

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Two hundred and nine cases of non-Hodgkin's lymphoma have been analyzed retrospectively for the occurrence of spontaneous regression (SR). Complete, partial or minor SR was found in 18 out of 140 cases with nodular lymphoma and in 2 out of 69 cases with diffuse lymphoma. Thus, SR occurs far more frequently in nodular lymphoma than in the diffuse type. Within the nodular lymphoma group, SR is associated with long survival. It occurred in previously treated and untreated patients and in nodal and extranodal disease; the duration varied from a few weeks to many years but lasted one year or more in 7 cases with complete or partial SR.

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Follicular Lymphoma With Full Remission of Leukemic Phase

Cited by 9 publications

References 8 publications

Haematological Remission of Leukaemic Polymorphic Immunocytoma Following Splenectomy

Haematological Remission of Leukaemic Polymorphic Immunocytoma Following Splenectomy

Spontaneous remission of leukemic lymphoproliferative disease

Spontaneous regression in non-Hodgkin's lymphoma

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