Follicular mucinosis: a clinicopathologic, histochemical, immunohistochemical and molecular study comparing the primary benign form and the mycosis fungoides‐associated follicular mucinosis

Abstract

Although no single, indisputable feature can reliably differentiate PFM from LAFM and a considerable overlapping among the two groups exists, the use of multiple clinical, histological and immunopathological criteria associated with gene rearrangement analysis can be useful in evaluation of those patients.

Clinical and histopathologic spectrum of alopecia mucinosa/follicular mucinosis and its natural history in children

“…17,20 However, lesion location alone is not helpful in discriminating isolated from MF-associated AM/ FM. 21 In both our patients with apparent early folliculotropic MF, the skin lesions were located on the trunk, buttocks, or thighs.…”

“…TCR monoclonality of the infiltrating lymphocytes is more common in cutaneous T-cell lymphoma than in AM/FM, but the presence or absence of this finding cannot differentiate between these entities. 21,23 Furthermore, neither T-cell phenotype nor T-cell clonality are currently considered as prognostic factors in AM/FM or in early MF. 24 Therefore, we chose not to perform routine immunohistopathologic studies and TCR gene rearrangement in our patients.…”

Familial follicular mucinosis: A case letter

“…However, the presence of a bandlike infiltrate of lymphocytes with enlarged, hyperchromatic, irregular nuclei is more frequently associated with secondary, malignancy-associated follicular mucinosis. 5 The origin of follicular mucinosis remains unknown, although the theory of a T-lymphocyteemediated process has been put forth. 3 To our knowledge, this case represents the first report of familial follicular mucinosis and highlights the current therapeutic challenges in treating primary follicular mucinosis.…”

Pathologic Diagnosis of Cutaneous Lymphomas

“…The detection of significant nuclear atypia, an elevated CD4/CD8 ratio, the presence of numerous CD30 1 -cells, and monoclonal rearrangement of TCR genes as well as the clinical features with multiple alopecic patches and patches or papular lesions indicate MF, whereas the occurrence of a solitary lesion in a young patient, particularly in children, and lack of nuclear atypia argue for idiopathic follicular mucinosis. 19 In addition, other forms of CTCLs such as follicular LyP and ATLL, which can manifest with folliculotropic infiltrates and accompanying follicular mucinosis, have to be distinguished from folliculotropic MF. 20,21 Folliculotropic MF and granulomatous MF carry an impaired prognosis of approximately 60% to 70% 5-year survival rate.…”