2015
DOI: 10.1089/thy.2015.0297
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Follicular Thyroid Carcinoma: How Have Histologic Diagnoses Changed in the Last Half-Century and What Are the Prognostic Implications?

Abstract: Over the past 50 years, changes in our understanding of the pathogenesis, histology, and behavior of thyroid carcinoma may partially account for the changes in histologic diagnosis. Elimination of PTC and FA "contaminants" led to decrease in survival following reclassification. Variability in histologic interpretation contributes to diagnostic challenges in follicular lesions. Histologic review of thyroid tumors for research studies is crucial, especially given the ever-changing diagnostic criteria.

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Cited by 70 publications
(50 citation statements)
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“…In addition, transcripts, which were altered in both oncocytic and non-oncocytic subgroups, exhibited consistently higher fold-changes in the oncocytic group versus non-oncocytic counterparts (compare subgroups 4–6 to 2–3 in Table 1 and subgroups 3 and 2 at Table 2). These data further support the hypothesis that oncocytic and non-oncocytic variants of human thyroid carcinomas might bear distinct molecular pattern [36]. Additionally, FTC with vascular invasion exhibited more pronounced changes of molecular markers, if compared to their counterparts without vascular invasion (Table 1), further suggesting that vascular invasion represents a hallmark of malignancy, accompanied by dramatic changes in the molecular pattern [36].…”
Section: Discussionsupporting
confidence: 78%
“…In addition, transcripts, which were altered in both oncocytic and non-oncocytic subgroups, exhibited consistently higher fold-changes in the oncocytic group versus non-oncocytic counterparts (compare subgroups 4–6 to 2–3 in Table 1 and subgroups 3 and 2 at Table 2). These data further support the hypothesis that oncocytic and non-oncocytic variants of human thyroid carcinomas might bear distinct molecular pattern [36]. Additionally, FTC with vascular invasion exhibited more pronounced changes of molecular markers, if compared to their counterparts without vascular invasion (Table 1), further suggesting that vascular invasion represents a hallmark of malignancy, accompanied by dramatic changes in the molecular pattern [36].…”
Section: Discussionsupporting
confidence: 78%
“…However, apart from the strict requirements for high-end and expensive devices, RTE still faces significant issues; for instance, it is nearly impossible to adequately examine multinodular goiters in order to identify follicular thyroid carcinoma [83]. The diagnostic drawbacks could be attributed to the specific soft textures of follicular carcinomas, which differ from the substantial firmness of other malignant nodules [84]. The differentiation of nodules, however, is strictly dependent on the stiffness of the tissue under compression [85].…”
Section: Discussionmentioning
confidence: 99%
“…The histological diagnosis of FC has changed in the last few decades [5] . Figure 1 illustrates a case of HCC from our institute, reviewed by our pathologist Dr. Angus Kirby in 2016 before the submission of this manuscript.…”
Section: Updates On Diagnosis and Investigationsmentioning
confidence: 99%
“…while multifocal disease, size of primary, nodal involvement, metastases, stage, microscopic residual disease, extra-glandular invasion, and degree of invasion are factors for both survival and recurrence. On follow-up, the loco-regional recurrence rates range from 3% to 50% and distant recurrence rates are 17%-27% in literature [3,5,61,62] .…”
mentioning
confidence: 99%