Identification of CHEK1, SLC26A4, c-KIT, TPO and TG as new biomarkers for human follicular thyroid carcinoma

Makhlouf, A; Chitikova, Zhanna; Pusztaszeri, Marc; Berczy, Margaret; Delucinge-Vivier, Céline; Triponez, Frédéric; Meyer, Patrick; Philippe, Jacques; Dibner, Charna

doi:10.18632/oncotarget.10166

Cited by 26 publications

(42 citation statements)

References 42 publications

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“…This characteristic implies the potential relationship between MOCS3 and MSI. Apart from such two functional substrate synthesis regulatory genes, TPO which is also in our optimal prediction gene list encodes a membrane‐bound glycoprotein and contributes to the synthesis of thyroid gland bioactive substances . Though not reported exactly in colorectal cancer, such gene has been reported to contribute to the pathogenesis of MSI by interfering DNA mismatch repair in multiple tumor subtypes like breast cancer, implying such predicted gene may also be a functional gene associated with tumor driving MSI.…”

Section: Discussionmentioning

confidence: 99%

Gene expression differences among different MSI statuses in colorectal cancer

Lei

Pan

et al. 2018

Intl Journal of Cancer

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Colorectal cancer is the third most common cancer in males and second in females. This disease can be caused by genetic and acquired/environmental factors. Microsatellite instability (MSI) is one of the major mechanisms in colorectal cancer. This mechanism is a specific condition of genetic hyper mutability that results from incompetent DNA mismatch repair. MSI has been applied to classify different colorectal cancer subtypes. However, the effects of MSI status on gene expression are largely unknown. In our study, we integrated the gene expression profile and MSI status of all CRC samples from the TCGA database, and then categorized the CRC samples into three subgroups, namely, MSI-stable, MSI-low, and MSI-high, according to the MSI status. We applied a novel computational method based on machine learning and screened the genes specifically expressed for the different colorectal cancer subtypes. The results showed the distinct mechanisms of the different colorectal cancer subtypes with MSI status and provided the genes that may be the optimal standards to further classify the various molecular subtypes of colorectal cancer with distinct MSI status.

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Section: Discussionmentioning

confidence: 99%

Gene expression differences among different MSI statuses in colorectal cancer

Lei

Pan

et al. 2018

Intl Journal of Cancer

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“…Our data showed that SLS5A5 was also identified as a risk factor (OR: 6.15). SLC5A is widely expressed in human tissues, including thyroid tissue [ 59 – 61 ] and is frequently methylated in human cancers [ 33 – 36 ], including thyroid cancer [ 61 – 64 ]. The SLC5A Meta bias test and resulting Egger graph showed that there was no the publication bias for association between the methylation of this gene and thyroid cancer.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of promoter methylation in eight tumor-suppressor genes and its association with the risk of thyroid cancer

et al. 2017

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Promoter methylation in a number of tumor-suppressor genes (TSGs) can play crucial roles in the development of thyroid carcinogenesis. The focus of the current meta-analysis was to determine the impact of promoter methylation of eight selected candidate TSGs on thyroid cancer and to identify the most important molecules in this carcinogenesis pathway. A comprehensive search was performed using Pub Med, Scopus, and ISI Web of Knowledge databases, and eligible studies were included. The methodological quality of the included studies was evaluated according to the Newcastle Ottawa scale table and pooled odds ratios (ORs); 95% confidence intervals (CIs) were used to estimate the strength of the associations with Stata 12.0 software. Egger’s and Begg’s tests were applied to detect publication bias, in addition to the “Metatrim” method. A total of 55 articles were selected, and 135 genes with altered promoter methylation were found. Finally, we included eight TSGs that were found in more than four studies (RASSF1, TSHR, PTEN, SLC5A, DAPK, P16, RARβ2, and CDH1). The order of the pooled ORs for these eight TSGs from more to less significant was CDH1 (OR = 6.73), SLC5 (OR = 6.15), RASSF1 (OR = 4.16), PTEN (OR = 3.61), DAPK (OR = 3.51), P16 (OR = 3.31), TSHR (OR = 2.93), and RARβ2 (OR = 1.50). Analyses of publication bias and sensitivity confirmed that there was very little bias. Thus, our findings showed that CDH1 and SCL5A8 genes were associated with the risk of thyroid tumor genesis.

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“…154 Along with these findings, temporal profiles of serum and skeletal muscle metabolites are strongly affected by the type of nutrients and by meal timing. 42,56,137,[161][162][163] Elegant mechanistic studies have provided molecular links between the circadian clock and cell cycle, suggesting a direct role for core clock proteins in regulating key components of cell cycle progression, tumorigenesis and DNA damage. 142 Perturbation of these rhythms leads to considerable cardiovascular problems including hypertension, which is often associated with metabolic diseases, and various other pathologies (Figure 2, right panel).…”

Section: When the Clock Goes Wrong: Circadian Misalignments In Humamentioning

confidence: 99%

“…159,160 Altered expression levels of individual core clock genes are | 7 of 14 DIBNER associated with the progression of oncogenic transformation, making these genes plausible candidates for diagnostic biomarkers. 42,56,137,[161][162][163] Elegant mechanistic studies have provided molecular links between the circadian clock and cell cycle, suggesting a direct role for core clock proteins in regulating key components of cell cycle progression, tumorigenesis and DNA damage. [164][165][166][167] Furthermore, emerging genetic and molecular studies suggest that alterations in molecular clock components are associated with depression, bipolar disease and other mood disorders.…”

Section: Goes Wrong: Circadian Misalignments In Human Pathologiesmentioning

confidence: 99%

The importance of being rhythmic: Living in harmony with your body clocks

Dibner

2019

Acta Physiologica

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OSCILLATORSThe time-keeping system, dubbed "circadian" from Latin circa diem (about a day), allows light-sensitive beings, including humans, to coordinate their physiology and behaviour to the daily changes in geophysical time (Figure 1). The mammalian network of body clocks is organized in a strictly hierarchical manner. A master oscillator, residing in the paired suprachiasmatic nuclei (SCN) of the hypothalamus ( Figure 1A), synchronizes a myriad of peripheral oscillators situated in each organ ( Figure 1B) on a daily basis. In turn, rhythmicity in the SCN is entrained by external timecues or Zeitgebers (German term for time givers). Daily changes in light intensity, detected by classical photoreceptors and intrinsically light-sensitive retinal ganglion cells expressing AbstractCircadian rhythms have developed in all light-sensitive organisms, including humans, as a fundamental anticipatory mechanism that enables proactive adaptation to environmental changes. The circadian system is organized in a highly hierarchical manner, with clocks operative in most cells of the body ensuring the temporal coordination of physiological processes. Circadian misalignment, stemming from modern life style, draws increasing attention due to its tight association with the development of metabolic, cardiovascular, inflammatory and mental diseases as well as cancer.This review highlights recent findings emphasizing the role of the circadian system in the temporal orchestration of physiology, with a particular focus on implications of circadian misalignment in human pathologies. K E Y W O R D Scircadian clock, circadian misalignment, continuous recording of circadian bioluminescence, human physiology How to cite this article: Dibner C. The importance of being rhythmic: Living in harmony with your body clocks. Acta Physiol. 2020;228:e13281. https ://doi.

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Identification of CHEK1, SLC26A4, c-KIT, TPO and TG as new biomarkers for human follicular thyroid carcinoma

Cited by 26 publications

References 42 publications

Gene expression differences among different MSI statuses in colorectal cancer

Gene expression differences among different MSI statuses in colorectal cancer

Meta-analysis of promoter methylation in eight tumor-suppressor genes and its association with the risk of thyroid cancer

The importance of being rhythmic: Living in harmony with your body clocks

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