Follicular Variant of Papillary Thyroid Carcinoma: Cytological Indicators of Diagnostic Value

Manimaran, D; Karthikeyan, T M; Khan, Dost Mohamed; R, Thulasi Raman

doi:10.7860/jcdr/2014/7477.4103

Cited by 7 publications

(2 citation statements)

References 17 publications

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“…33 However, nuclear grooves and pseudoinclusions in NIFTP and FVPTC are less evident compared to PTC. 35,36 NIFTP shows predominantly follicular growth pattern with < 1% papillary formations, and no capsular or vascular invasion. 37…”

Section: Discussionmentioning

confidence: 98%

Understanding and Overcoming the Pitfalls in Cytopathological Diagnosis of Hyalinizing Trabecular Tumor of Thyroid

et al. 2023

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Hyalinizing trabecular tumor (HTT), a rare low-malignant-potential thyroid neoplasm, is usually treated with conservative surgery. However, cytomorphological diagnosis of HTT is challenging due to the significant overlap of nuclear features with more common malignancies such as papillary thyroid carcinoma (PTC), which usually requires more radical surgical intervention. To avoid unnecessary overtreatment, a precise diagnosis of HTT is therefore essential. Advances in molecular diagnostics provide the opportunity to overcome the limitations of cytological analysis. We present a case of HTT in a 71-year-old male who was initially suspected to be PTC based on cytopathology. However, further molecular analysis revealed PAX8::GLIS3 gene fusion, classifying the lesion as HTT and preventing surgical overtreatment. We discuss the diagnostic pitfall of cytopathology in HTT and suggest using emerging molecular genetic tools to avoid it.

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Section: Discussionmentioning

confidence: 98%

Understanding and Overcoming the Pitfalls in Cytopathological Diagnosis of Hyalinizing Trabecular Tumor of Thyroid

et al. 2023

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“…Our study has also shown association between FVPTC and distant metastasis when compared with the classical subtype. Therefore, inactivation of PTEN in this particular subtype of PTC could probably have several clinical implications as other studies have revealed the diagnostic and clinical challenges associated with FVPTC as its molecular features are shared by both papillary thyroid cancers and follicular neoplasms ( Salajegheh et al , 2008 ; D et al , 2014 ).…”

Section: Discussionmentioning

confidence: 99%

PTEN loss is associated with follicular variant of Middle Eastern papillary thyroid carcinoma

et al. 2015

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Background:PTEN gene at chromosomes 10q23.3 is a tumour suppressor gene that is inactivated in many types of human cancers. The known mechanisms of PTEN inactivation are rendered to mutation, epigenetic silencing by aberrant methylation or gene deletion. Although PTEN role has been documented in many cancers, PTEN alteration in papillary thyroid carcinoma (PTC) has not been fully elucidated. The aim of this study is to comprehensively investigate PTEN alterations in a large cohort of Middle Eastern papillary thyroid cancer by immunohistochemistry and fluorescent in situ hybridisation (FISH).Methods:PTEN protein expression was analysed by immunohistochemistry in a tissue microarray (TMA) format in a large cohort of more than 1000 patients with papillary thyroid cancer. Copy number changes in PTEN were analysed by FISH and data were correlated with clinicopathological parameters along with survival analysis.Results:PTEN inactivation reflected by complete absence of staining was seen in 24.5% of PTC samples, whereas PTEN deletion was seen only in 4.8% of the tested samples by FISH. No association was seen between PTEN loss of protein expression and PTEN gene deletion. However, interestingly, PTEN loss of expression was significantly associated with the follicular variant subset of papillary thyroid cancer.Conclusion:Our study confirmed that PTEN might have a role in pathogenesis in a subset of PTC. PTEN loss of protein expression is a more common event in follicular variant of papillary thyroid cancer. Lack of association between PTEN loss of protein expression and PTEN gene deletion might indicate that gene deletion may not be the sole cause for PTEN loss of expression and these results might raise the possibility of other mechanism such as promoter methylation-mediated gene silencing to be responsible for PTEN inactivation.

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Follicular Neoplasm/Suspicious for Follicular Neoplasm

Hoda¹,

Rao

Scognamiglio

2019

Atlas of Thyroid Cytopathology on Liquid-Based Preparations

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Follicular Variant of Papillary Thyroid Carcinoma: Cytological Indicators of Diagnostic Value

Cited by 7 publications

References 17 publications

Understanding and Overcoming the Pitfalls in Cytopathological Diagnosis of Hyalinizing Trabecular Tumor of Thyroid

Understanding and Overcoming the Pitfalls in Cytopathological Diagnosis of Hyalinizing Trabecular Tumor of Thyroid

PTEN loss is associated with follicular variant of Middle Eastern papillary thyroid carcinoma

Follicular Neoplasm/Suspicious for Follicular Neoplasm

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