Follicular variant papillary thyroid carcinoma with a twist

Nwaeze, Obinna; Obidike, Stephen; Mullen, Dorinda; Aftab, Fuad

doi:10.1016/j.ijscr.2015.01.019

Cited by 7 publications

(17 citation statements)

References 12 publications

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“…Similarly, the latter case also involved the liver, lungs, and some bony tissue [11]. It has been observed that metastatic lesions from follicular variant of papillary thyroid cancer typically show papillary formation [12]. In our case, the follicular formation was seen at the primary tumor and at the metastatic sites.…”

Section: Discussionsupporting

confidence: 61%

Rare behavior of follicular variant of papillary thyroid cancer

Helmi

Idrees

Alshehri

et al. 2017

Clinical Case Reports

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Section: Discussionsupporting

confidence: 61%

Rare behavior of follicular variant of papillary thyroid cancer

Helmi

Idrees

Alshehri

et al. 2017

Clinical Case Reports

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“…Women were more represented with the 53.7% (66/123) of cases, compared to the 46.3% (57/123) of men . Median age of AN at onset was 59 (IQR: 47–68).…”

Section: Resultsmentioning

confidence: 99%

Alopecia neoplastica as a sign of visceral malignancies: a systematic review

Paolino

Pampena

Grassi

et al. 2019

Acad Dermatol Venereol

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Alopecia neoplastica (AN) from visceral tumours is a rare form of cutaneous metastasis in which internal malignancies spread to the scalp. The diagnosis of AN may be very challenging, especially when its onset precedes the diagnosis of the primary tumour. We aimed to improve the knowledge on AN, highlighting that in case of scarring localized alopecia, a differential diagnosis with metastasis should always be considered. We performed a systematic review to describe the main demographic and clinical features associated with AN from visceral malignancies; a survival analysis was also performed. In 118 reports, accounting for 123 patients, we found that women were more affected by AN than men (53.7% vs. 46.3%). The most frequent site of the primary tumour was the gastrointestinal tract (24.4%), followed by breast (17.9%), kidney (8.1%), lung (7.3%), thyroid (7.3%), uterus (6.5%), central nervous system (6.5%), liver (3.3%) and other anatomic areas for 18.7% of cases. Furthermore, in more than half of the cases (66.1%), AN lesions were single and were mainly diagnosed after the primary visceral tumour (71.5%). Finally, survival analysis highlighted a lower progression‐free survival in men; while, no significant differences in overall survival were reported among genders. In conclusion, metastatic skin disease should always be taken into consideration when dealing with patients with localized scarring alopecia.

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“…If tumour removal is less indicated in mentioned pituitary and adrenal incidentalomas, surgery for an incidental thyroid nodule is recommended depending on complex risk stratification strategy of approach (1,22,27). Incidental finding of a skin lump originating from a thyroid cancer remains an exceptional scenario (28,29,30). Whole body imagery evaluation may show the general metastatic context if positive or it may suggest the thyroid origin especially in patients with prior thyroidectomy and a certain disease free interval (28,29,30).…”

Section: Incidental Findingsmentioning

confidence: 99%

“…Incidental finding of a skin lump originating from a thyroid cancer remains an exceptional scenario (28,29,30). Whole body imagery evaluation may show the general metastatic context if positive or it may suggest the thyroid origin especially in patients with prior thyroidectomy and a certain disease free interval (28,29,30). Overall, histological report, radioiodine uptake at scintigraphy or high circulating thyroglobulin of otherwise unexplained source are the best assessments for an adequate diagnosis and further therapy even the general prognosis is considered severe in this cases (28,29,30).…”

Section: Incidental Findingsmentioning

confidence: 99%

Skin metastasis as incidental finding in follicular epithelium derived – thyroid cancer

Şandru¹,

Valea²,

Albu³

et al. 2020

Ro J Med Pract.

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Skin metastases are not typical. Malignancies like mammary cancer (most frequent in females) and pulmonary neoplasia (most frequent in males) represent the majority and exceptional findings are in those originating from thyroid, prostate, ovaries and oesophagus, usually in advanced, generally disseminated stages, with a poor prognosis. It may be found more often in elderly patients. We aim to present some practical aspects of skin metastases in thyroid cancer that originates from follicular thyroid epithelium. This is a brief literature review. The level of evidence is poor since most data is provided from cases reports. Cutaneous malignant lumps are rarely the first sign of disease, mostly associating a cancer relapse. The location varies from neck and head (majority) to exceptional sites as chest wall and of variable rate for scalp. Underling neck muscle or Meckel's cave metastasis may be associated. The lesion is usually a lump of medium to small size, sometimes of papular appearance, without local pain (but depends on the site); it may associate erythema. The diagnosis is difficult unless an index of suspicion is positive (in which case whole body radioiodine scintigram may be useful). Biopsy and histological report are essential for diagnosis especially in cases without an evident connection to a prior/synchronous thyroid malignancy. Knowing the exceptional prevalence, the need for awareness in this particular topic is connected with a multidisciplinary daily practice.

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Follicular variant papillary thyroid carcinoma with a twist

Cited by 7 publications

References 12 publications

Rare behavior of follicular variant of papillary thyroid cancer

Rare behavior of follicular variant of papillary thyroid cancer

Alopecia neoplastica as a sign of visceral malignancies: a systematic review

Skin metastasis as incidental finding in follicular epithelium derived – thyroid cancer

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