Follistatin and activins in polycystic ovary syndrome: Relationship to metabolic and hormonal markers

Teede, Helena; Ng, Sze; Hedger, Mark P.; Moran, Lisa J.

doi:10.1016/j.metabol.2013.05.003

Cited by 38 publications

(22 citation statements)

References 38 publications

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“…This hypothesis could explain the decreased follistatin levels reported in obese individuals [5]. An alternative hypothesis for the association between follistatin and leptin could be that, besides muscle, follistatin also promotes adipose tissue increase [5] which could explain the increased levels of follistatin reported in patients with type 2 diabetes [10], PCOs [11] and NAFLD [12]. Furthermore, follistatin may positively affect acute and chronic inflammatory conditions through interaction with inflammatory/immune mediators [20, 24].…”

Section: Discussionmentioning

confidence: 99%

“…However, follistatin has been proposed to be an adipokine [5] while recent data suggest an endocrine production from the liver [6] in response to stimuli such as acute exercise [7] or feeding status [8] and the physiological role of follistatin and follistatin-like molecules has expanded to the regulation of fat and lean mass and muscle growth, through activin and myostatin inhibition [2, 9]. Furthermore, follistatin has been implicated in the pathogenesis of muscle atrophy [3] and of metabolic diseases, as it has been reported to be elevated in patients with type 2 diabetes [10], polycystic ovary syndrome (PCOs) [11] and nonalcoholic fatty liver disease (NAFLD) [12]. Thus follistatin may represent an appealing therapeutic target for muscle disorders [13] and metabolic diseases.…”

Section: Introductionmentioning

confidence: 99%

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Circulating follistatin displays a day–night rhythm and is associated with muscle mass and circulating leptin levels in healthy, young humans

et al. 2016

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Purpose Follistatin may affect lean and fat mass and be implicated in metabolic diseases. We aimed to elucidate physiological predictors of circulating follistatin variation in healthy young humans. Procedures This was an observational, cross-sectional study with two additional prospective observational arms (circadian, seasonal sub-studies) and one prospective interventional arm (mixed meal sub-study). Healthy, young individuals of both sexes (n=122) were subjected to anthropometric and body composition measurements and their eating and exercise behavior profiles were assessed by validated questionnaires. Sub-groups were subjected to standardized meal ingestion (n=36), day-night rhythm (n=20) and seasonal variation (n=20) studies. Main outcome of the study were circulating follistatin levels. Results At baseline follistatin levels were correlated with creatinine (r=0.24; p=0.01), creatine phosphokinase (rs=0.22; p=0.02), and with lean body mass (rs=0.19; p=0.04) and were higher in males than females (p=0.004) after adjustment for leptin, which was its major predictor. Follistatin levels showed a circadian (p<0.001), but not a seasonal, variation, and were also affected by the phase of menstrual cycle in females (p=0.004). Follistatin levels were not affected by dietary or exercise habits but levels increased after a standardized meal ingestion (250 kcal) (p=0.002). Conclusions In healthy young individuals circulating follistatin levels are correlated with muscle mass. Follistatin levels are associated with circulating leptin levels and display a day-night rhythm and a menstrual cycle, but not a seasonal, variation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Circulating follistatin displays a day–night rhythm and is associated with muscle mass and circulating leptin levels in healthy, young humans

et al. 2016

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“…In a recent study, the relationship of activins and follistatins with metabolic markers in PCOS was investigated (22). Serum follistatin levels were found to be elevated in PCOS patients, independent of age and BMI.…”

Section: Metabolic Markers Of Metabolic Syndrome In Pcosmentioning

confidence: 99%

What do we know about metabolic syndrome in adolescents with PCOS?

Cırık

Dilbaz

2014

J Turkish German Gynecol Assoc

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“… 11 – 15 Follistatin promotes adipocyte differentiation, browning, and energy metabolism. 11 , 12 Plasma follistatin is elevated in patients with polycystic ovary syndrome 13 or in patients with type 2 diabetes. 14 Systemic administration of follistatin increases body weight and lean muscle mass in normal mice.…”

Section: Introductionmentioning

confidence: 99%

Serum Levels of Follistatin Are Positively Associated With Serum-Free Thyroxine Levels in Patients With Hyperthyroidism or Euthyroidism

et al. 2016

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Follistatin is a glycoprotein with various biologic functions that plays a role in adipocyte differentiation, muscle stimulation, anti-inflammation, and energy homeostasis. Thyroid hormones influence energy expenditure, glucose, and lipid metabolism. The association between serum follistatin level and thyroid function statuses has seldom been evaluated.The objectives of this study were to compare serum follistatin concentrations in different thyroid function statuses and to evaluate the associations between serum follistatin and free thyroxine (fT4) levels.In this study, 30 patients with hyperthyroidism (HY group) and 30 euthyroid individuals (EU group) were recruited. The patients of HY group were treated with antithyroid regimens as clinically indicated, whereas no medication was given to EU group. The demographic and anthropometric characteristics, biochemical data, serum levels of follistatin, and thyroid function of both groups at baseline and at the 6th month were compared. Data of all patients were pooled for the analysis of the associations between the levels of follistatin and fT4.At baseline, the HY group had significantly higher serum follistatin levels than the EU group (median [Q1, Q3]: 1.81 [1.33, 2.78] vs 1.13 [0.39, 1.45] ng/mL, P < 0.001). When treated with antithyroid regimens, the follistatin serum levels in HY group decreased to 1.54 [1.00, 1.88] ng/mL at the 6th month. In all patients, the serum levels of follistatin were positively associated with fT4 levels at baseline (β = 0.54, P = 0.005) and at the 6th month (β = 0.59, P < 0.001). The association between follistatin and fT4 levels remained significant in the stepwise multivariate regression analysis, both initially and at the 6th month.In comparison to the EU group, patients with hyperthyroidism had higher serum follistatin levels, which decreased after receiving antithyroid treatment. In addition, the serum follistatin concentrations were positively associated with serum fT4 levels in patients with hyperthyroidism or euthyroidism.

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Follistatin and activins in polycystic ovary syndrome: Relationship to metabolic and hormonal markers

Cited by 38 publications

References 38 publications

Circulating follistatin displays a day–night rhythm and is associated with muscle mass and circulating leptin levels in healthy, young humans

Circulating follistatin displays a day–night rhythm and is associated with muscle mass and circulating leptin levels in healthy, young humans

What do we know about metabolic syndrome in adolescents with PCOS?

Serum Levels of Follistatin Are Positively Associated With Serum-Free Thyroxine Levels in Patients With Hyperthyroidism or Euthyroidism

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