Follow-up of 100 dogs with acute diarrhoea in a primary care practice

Berset, Corina; Glardon, Olivier; Magouras, Ioannis; Frey, Caroline F.; Gobeli, Stefanie; Burgener, Iwan

doi:10.1016/j.tvjl.2013.10.014

Cited by 18 publications

(12 citation statements)

References 7 publications

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“…The prevalence of C. perfringens found in this study is similar to those reported in other studies, which demonstrated that 61% to 94% DD subjects and 56% to 88% ND subjects had C. perfringens in their feces [ 2 9 10 15 20 22 29 32 34 ]. Although some researchers have found a significant difference between C. perfringens prevalence in DD and ND [ 15 34 ], it has been reported that a high occurrence frequency of the bacterium is not an indicative or diagnostic sign of C. perfringens -associated disease [ 9 ].…”

Section: Discussionsupporting

confidence: 91%

“…Evaluation of the distribution of C. perfringens strains and assessment of their traits, such as toxin profiles, are important to elucidating the role of C. perfringens in canine diarrhea. Although there have been numerous reports on the prevalence of C. perfringens strains and their toxin profiles in fecal samples from diarrheic dogs (DD) and non-diarrheic dogs (ND) [ 2 9 10 15 20 22 29 32 34 ], studies detailing the prevalence of toxin genes, relatedness between DD and ND strains, and their antimicrobial susceptibility profiles have not been conducted in Korea.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence, toxin gene profile, antibiotic resistance, and molecular characterization ofClostridium perfringensfrom diarrheic and non-diarrheic dogs in Korea

et al. 2018

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Clostridium perfringens causes diarrhea and other diseases in animals and humans. We investigated the prevalence, toxin gene profiles, and antibiotic resistance of C. perfringens isolated from diarrheic dogs (DD) and non-diarrheic dogs (ND) in two animal hospitals in Seoul, Korea. Fecal samples were collected from clinically DD (n = 49) and ND (n = 34). C. perfringens was isolated from 31 of 49 DD (63.3%) and 21 of 34 ND dogs (61.8%). All C. perfringens strains were positive for the α toxin gene, but not for the β, ε, or ι toxin genes; therefore, all strains were identified as type A C. perfringens. All isolates were cpe-negative, whereas the β2 toxin gene was identified in 83.9% and 61.9% of isolates from DD and ND, respectively. Most isolates were susceptible to ampicillin (94%), chloramphenicol (92%), metronidazole (100%), moxifloxacin (96%), and imipenem (100%). However, 25.0% and 21.2% of isolates were resistant to tetracycline and clindamycin, respectively. Molecular subtyping of the isolated strains was performed by using pulsed-field gel electrophoresis. Fifty-two isolates were classified into 48 pulsotypes based on more than 90% similarity of banding patterns. No notable differences were observed among the isolates from DD and ND.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Prevalence, toxin gene profile, antibiotic resistance, and molecular characterization ofClostridium perfringensfrom diarrheic and non-diarrheic dogs in Korea

et al. 2018

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“…In many cases the etiology cannot be identified. This is usually not a problem, because clinical signs typically resolve spontaneously and usually do not recur 2,4,7‐9 . International guidelines recommend that in dogs with diarrhea, antimicrobials should only be administered to dogs manifesting systemic signs of illness 10‐14 .…”

Section: Introductionmentioning

confidence: 99%

Effect of amoxicillin‐clavulanic acid on clinical scores, intestinal microbiome, and amoxicillin‐resistant Escherichia coli in dogs with uncomplicated acute diarrhea

Werner

Suchodolski

Straubinger

et al. 2020

Veterinary Internal Medicne

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“…The causes of acute diarrhea are varied. Infectious organisms and parasites account for some cases, but routine diagnostic testing often fails to identify a specific cause . Extensive diagnostic tests are seldom performed because the yield is low, especially if the patient is clinically stable .…”

Section: Introductionmentioning

confidence: 99%

Metronidazole treatment of acute diarrhea in dogs: A randomized double blinded placebo‐controlled clinical trial

Langlois

Koenigshof

Mani

2019

Veterinary Internal Medicne

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Background: Metronidazole is commonly administered to dogs with acute diarrhea, but there is limited evidence to support this practice.Objective: To investigate the effects of metronidazole administration on dogs with acute nonspecific diarrhea.Animals: Thirty-one dogs, including 14 test population dogs and 17 controls.Methods: Randomized controlled clinical trial. Dogs with acute diarrhea in which causation was not determined by routine fecal diagnostic testing were randomly assigned to metronidazole treatment (10-15 mg/kg PO q12h for 7 days) or placebo.Fecal cultures and characterization of Clostridium perfringens isolates also were performed. Owners maintained medication and fecal scoring logs, and fecal diagnostic tests were repeated on day 7.Results: The mean ± SD time to resolution of diarrhea for test population dogs (2.1 ± 1.6 days) was less than that for controls (3.6 ± 2.1 days, P = .04). Potential relationships of C. perfringens with acute diarrhea pathogenesis were not investigated, but only 3 of 13 (23.1%) test population dogs had persistent C. perfringens carriage at day 7, which was less than the 11 of 14 (78.6%) controls with persistent growth (P = .007).Conclusions and Clinical Importance: Our results suggest that metronidazole treatment can shorten duration of diarrhea and decrease fecal culture detection of C. perfringens in some dogs with acute nonspecific diarrhea. Additional studies are needed to assess the benefits and risks of routine use of metronidazole for this purpose because most dogs achieve resolution of diarrhea within several days regardless of treatment.

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Follow-up of 100 dogs with acute diarrhoea in a primary care practice

Cited by 18 publications

References 7 publications

Prevalence, toxin gene profile, antibiotic resistance, and molecular characterization ofClostridium perfringensfrom diarrheic and non-diarrheic dogs in Korea

Prevalence, toxin gene profile, antibiotic resistance, and molecular characterization ofClostridium perfringensfrom diarrheic and non-diarrheic dogs in Korea

Effect of amoxicillin‐clavulanic acid on clinical scores, intestinal microbiome, and amoxicillin‐resistant Escherichia coli in dogs with uncomplicated acute diarrhea

Metronidazole treatment of acute diarrhea in dogs: A randomized double blinded placebo‐controlled clinical trial

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