Follow up of the 987 blood donors found with hepatitis C virus infection over 9–18 years

Matsuo, Junko; Mizui, Masaaki; Okita, Hajime; Katayama, Keiko; Aimitsu, Shiomi; Sakata, Tetsu; Ōbayashi, M.; Nakanishi, Toshio; Chayama, Kazuaki; Miyakawa, Yuzo; Yamada, Hiroshi; Tanaka, Junko

doi:10.1111/j.1872-034x.2012.00966.x

Cited by 12 publications

(13 citation statements)

References 28 publications

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“…The results of a long‐term cohort study of HCV carriers who were found to be positive at blood donation revealed that only 1097 (32.5%) among 3377 HCV carriers who had received post‐test counselling had consulted at medical institutions for further examination, and 987 (29.2%) consulted twice or more . Among them, excluding loss‐to‐follow‐up because of transfer to other hospitals, the drop‐out rate in the 1–2 years after the initial visit was 24.3%.…”

Section: Estimate Of the Total Number Of Hepatitis Virus Carriersmentioning

confidence: 99%

“…After receiving passive–active immunization, all children were tested for HBsAg at 1 month of age and then HBsAg and anti‐HBs at 6 months of age. In 2015, the above prevention guideline was modified so that all children born to pregnant women positive for HBsAg, irrespective of their HBeAg status, were given HBIG and HepB vaccine at birth simultaneously, followed by another two doses of HepB vaccine at 1 month and 6 months of age …”

Section: Prevention Of Mother‐to‐child Transmission Of Viral Hepatitis Bmentioning

confidence: 99%

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Countermeasures against viral hepatitis B and C in Japan: An epidemiological point of view

Tanaka

Akita

et al. 2019

Hepatology Research

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Although the mortality rate due to hepatocellular carcinoma (HCC) has been gradually decreasing in Japan, approximately 30 000 people died of HCC in 2016. In 2007, the dominant etiology was persistent hepatitis C virus (HCV) infection, which accounted for 65% of total HCC deaths, and 15% of cases were due to chronic hepatitis B virus (HBV) infection. In managing chronic HBV and HCV infection, it is critically important to know the exact number of infected individuals in a particular country, which then assists in evaluating medical and financial needs in the foreseeable future. Therefore, from an epidemiological perspective, we estimated the numbers of HBV and HCV carriers in four categories: (i) undiagnosed carriers; (ii) carriers who were already hospitalized as patients or were receiving outpatient medical attention; (iii) diagnosed carriers who had not consulted any medical facility, or had discontinued consultation; and (iv) newly infected carriers. From these estimates we determined the current HBV and HCV burden and then reviewed the existing countermeasures for their prevention and control in Japan. While continuing the surveillance on the dynamics of hepatitis virus infections linked with preventive measures against hepatitis virus infection, it is crucially important to promote appropriate measures for each of the four groups of hepatitis virus carriers in society.

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Section: Estimate Of the Total Number Of Hepatitis Virus Carriersmentioning

confidence: 99%

Section: Prevention Of Mother‐to‐child Transmission Of Viral Hepatitis Bmentioning

confidence: 99%

Countermeasures against viral hepatitis B and C in Japan: An epidemiological point of view

Tanaka

Akita

et al. 2019

Hepatology Research

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“…In Japan, patients infected with HCV are getting increasingly older, and they are older than those in other countries [19, 26]. Matsuo et al [26] reported that HCC developed more frequently in blood donors in whom chronic hepatitis had been diagnosed at age >60 years than ≤59 years.…”

Section: Discussionmentioning

confidence: 99%

“…Matsuo et al [26] reported that HCC developed more frequently in blood donors in whom chronic hepatitis had been diagnosed at age >60 years than ≤59 years. In the era of direct-acting antivirals against HCV [27, 28], our current study strongly suggests that HCV-infected patients >50 years might be treated with antivirals as soon as possible.…”

Section: Discussionmentioning

confidence: 99%

Occurrence and Recurrence of Hepatocellular Carcinoma Were Not Rare Events during Phlebotomy in Older Hepatitis C Virus-Infected Patients

et al. 2014

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The use of phlebotomy is relatively common for ‘difficult-to-treat by antiviral therapies' hepatitis C virus (HCV)-infected patients and for certain patients having chronic liver diseases with an iron overload of the liver. In the present study, we retrospectively analyzed patients treated with phlebotomy and their adverse events. We observed the occurrence and recurrence of hepatocellular carcinoma, and the appearance of ascites in some patients infected with HCV as well as the reduction of serum ferritin and alanine aminotransferase levels. Severe adverse events necessitating a cessation of phlebotomy occurred independently of α-fetoprotein (≥10 ng/ml) in patients infected with HCV according to multivariate logistic regression analysis. These findings may serve as a basis for phlebotomy especially in older patients with chronic hepatitis C.

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“…Conforme evidenciado por diversos trabalhos na literatura médica, a triagem sorológica dos Bancos de Sangue possibilita a oportunidade de identificar os indivíduos assintomáticos portadores da hepatite C, que precisam de acompanhamento médico e, que de outra forma, não teriam o conhecimento da doença e não seriam encaminhados para receber a assistência necessária 28,48,49,57,61 . Além da possibilidade de reconhecimento precoce da hepatite C, o diagnóstico durante a doação de sangue, seguido por um programa de saúde com acompanhamento regular destes pacientes e com a indicação de tratamento no momento adequado, está associado a melhores desfechos clínicos e melhores resultados do tratamento antiviral, como mostrado no trabalho publicado por Matsuo, em que mais de 900 doadores de sangue foram seguidos prospectivamente e tiveram seus desfechos analisados 58 .…”

Section:  Biópsias Hepáticasunclassified

Seguimento clínico de pacientes identificados como portadores do vírus da hepatite C através da doação de sangue

Machado¹

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AGRADECIMENTOSAgradeço aos meus pais, Elisa e Cyrillo, e ao meu irmão Guilherme por todo amor e apoio incondicionais.À minha orientadora, Professora Doutora Maria Cássia Jacintho Mendes Corrêa, pela orientação neste trabalho e por seu exemplo de sabedoria, compreensão, dedicação, simplicidade e incentivo. O meu leal e carinhoso reconhecimento.Ao enfermeiro Aparecido Braz por sua competência e companheirismo, por sempre ter estado ao nosso lado tentando solucionar os problemas, possibilitando a realização do presente estudo.

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Follow up of the 987 blood donors found with hepatitis C virus infection over 9–18 years

Abstract: Individuals with undiagnosed HCV infection need to be identified and receive medical care. They have to be motivated to merit from this health-care program.

Cited by 12 publications

References 28 publications

Countermeasures against viral hepatitis B and C in Japan: An epidemiological point of view

Countermeasures against viral hepatitis B and C in Japan: An epidemiological point of view

Occurrence and Recurrence of Hepatocellular Carcinoma Were Not Rare Events during Phlebotomy in Older Hepatitis C Virus-Infected Patients

Seguimento clínico de pacientes identificados como portadores do vírus da hepatite C através da doação de sangue

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