Food biopharmaceuticals as part of a sustainable bioeconomy: Edible vaccines case study

Miranda, Elena Cebadera; Ruiz-Cabello, Ma Victoria Castillo; Hurtado, Montaña Cámara

doi:10.1016/j.nbt.2020.06.005

Cited by 8 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…World governments face challenges such as feeding a growing population and mitigating environmental and social impacts while pursuing economic growth (Miranda et al 2020 ). As part of the solution to these global challenges, a bioeconomy encompasses production from the biological basis and its conversion into food, feed, and bioenergy (Aguilar et al 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Pharmaceutical, food potential, and molecular data of Hancornia speciosa Gomes: a systematic review

Nunes

Silva-Mann

Souza

et al. 2022

Genet Resour Crop Evol

View full text Add to dashboard Cite

Hancornia speciosa Gomes is a fruit and medicinal tree species native to South America, which in Brazil is considered of potential economic value and priority for research and development. We present a map of the state-of-art, including articles, patents, and molecular data of the species to identify perspectives for future research. The annual scientific production, intellectual, social, and conceptual structure were evaluated, along with the number of patent deposits, components of the plant used, countries of deposit, international classification and assignees, and the accessibility of available molecular data. Brazil has the most significant publications (306) between 1992 and 2020. Technological products (29) have been developed from different tissues of the plant. Most of the articles and patents were developed by researchers from public universities from different regions of Brazil. The molecular data are sequences of nucleotides (164) and proteins (236) of the chloroplast genome and are described to identify the species as DNA barcodes and proteins involved in photosynthesis. The compilation and report of scientific, technological, and molecular information in the present review allowed the identification of new perspectives of research to be developed based on the gaps in knowledge regarding the species and perspectives for the definition of future research. Supplementary Information The online version contains supplementary material available at 10.1007/s10722-021-01319-w.

show abstract

Section: Discussionmentioning

confidence: 99%

Pharmaceutical, food potential, and molecular data of Hancornia speciosa Gomes: a systematic review

Nunes

Silva-Mann

Souza

et al. 2022

Genet Resour Crop Evol

View full text Add to dashboard Cite

show abstract

“…Lettuce and tomato are preferred vegetable systems that can be consumed raw (Concha et al, 2017;Miranda et al, 2020). Lettuce (Lactuca sativa) varieties have been used to produce edible vaccines against swine fever, stage I hepatitis and E. coli (Kim et al, 2007).…”

Section: Leaf-based and Fruit-based Expression Platformsmentioning

confidence: 99%

Recent advances in expression and purification strategies for plant made vaccines

Venkataraman,

Khan,

Habibi

et al. 2023

Front. Plant Sci.

View full text Add to dashboard Cite

Plants have been explored as a platform to produce pharmaceutical proteins for over 20 years. Important features such as the cost-effectiveness of production, the ease of scaling up to manufacturing capacity, the lack of cold chain requirements and the ability to produce complex therapeutic proteins which are biologically and functionally identical to their mammalian counterparts, make plants a strong alternative for vaccine production. This review article focuses on both the expression as well as the downstream purification processes for plant made vaccines. Expression strategies including transgenic, transient and cell suspension cultures are outlined, and various plant tissues targeted such as leaves and seeds are described. The principal components used for downstream processing of plant made vaccines are examined. The review concludes with a reflection of the future benefits of plant production platforms for vaccine production.

show abstract

“…A novel concept named "Therapeutic food" or "Ready to Use Therapeutic Food" notified by FAO might be helpful for the availability of edible vaccines as biopharmaceuticals. Adoption of edible vaccines as biopharmaceuticals would be dually beneficial, that is, the problem of malnutrition would be solved along with improved global health (Cebadera Miranda et al, 2020). Till now, no edible vaccines have been in the market or approved by the USFDA as these are basically genetically modified crops (M.-Y.…”

mentioning

confidence: 99%

Insight of oral vaccines as an alternative approach to health and disease management: An innovative intuition and challenges

Debnath

Thakur

Khushboo

et al. 2021

Biotech & Bioengineering

View full text Add to dashboard Cite

Vaccination is the most suitable and persuasive healthcare program for the prohibition of various deadly diseases. However, the higher production cost and purification strategies are out of reach for the developing nations. In this scenario, development of edible vaccine turns out to be the most promising alternative for remodeling the pharmaceutical industry with reduced production and purification costs. Generally, oral route of vaccination is mostly preferred due to its safety, compliance, low manufacturing cost and most importantly the ability to induce immunity in both systemic and mucosal sites. Genetically modified microorganisms and plants could efficiently be used as vehicles for edible vaccines. Edible vaccines are supposed to reduce the risk associated with traditional vaccines. Currently, oral vaccines are available in the market for several viral and bacterial diseases like cholera, hepatitis B, malaria, rabies etc. Herein, the review focuses on the breakthrough events in the area of edible vaccines associated with dietary microbes and plants for better control over diseases.

show abstract

Food biopharmaceuticals as part of a sustainable bioeconomy: Edible vaccines case study

Cited by 8 publications

References 30 publications

Pharmaceutical, food potential, and molecular data of Hancornia speciosa Gomes: a systematic review

Pharmaceutical, food potential, and molecular data of Hancornia speciosa Gomes: a systematic review

Recent advances in expression and purification strategies for plant made vaccines

Insight of oral vaccines as an alternative approach to health and disease management: An innovative intuition and challenges

Contact Info

Product

Resources

About