Food-derived bioactive peptides: Mechanisms of action underlying inflammation and oxidative stress in the central nervous system

Galland, Fabiana; Espindola, Juliana Santos de; Lopes, Daniel Saraiva; Taccóla, Milena Ferreira; Pacheco, Maria Teresa Bertoldo

doi:10.1016/j.focha.2022.100087

Cited by 17 publications

(7 citation statements)

References 100 publications

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“…3 -REVISÃO DE LITERATURA 3.1 -Efeito das nanopartículas contendo peptídeos bioativos sobre os processos neuro inflamatórios e estresse oxidativo A utilização de peptídeos bioativos na área nutracêutica e médica tem aumentado devido a sua alta bioatividade em diferentes sistemas biológicos (MARTINEZ-SANCHEZ; GABALDÓN-HERNÁNDEZ; MONTORO-GARCÍA, 2020), tais como atividade antioxidante (GRAZIANI et al, 2021;PAULA et al, 2022), atividade quelante (RIBEIRO; BATISTA; FERNANDES, 2019), atividade anti-hipertensiva (NAKAHARA et al, 2010), antitrombótica (CHENG et al, 2019, antihiperglicemiante e hipoglicemiante (VALENCIA-MEJÍA et al, 2019), hipocolesterêmica (FERREIRA et al, 2015) , anti-inflamatória (GALLAND et al, 2022), ansiolítica (CHATAIGNER et al, 2021). A bioatividade dos peptídeos bioativos se dá pela composição de aminoácidos, estrutura e tamanho molecular (GRAZIANI et al, 2021;PAULA et al, 2022;RIBEIRO, 2017).…”

Section: -Metodologiaunclassified

“…A presença de aminoácidos hidrofóbicos carregados positivamente, por exemplo, é uma característica importante para a atividade antioxidante e anti-inflamatória (LI et al, 2018). Já o tamanho do peptídeo contribui para o poder de penetrabilidade nos tecidos, maior afinidade em interagir com compostos intracelulares e receptores de membrana, podendo inibir ou ativar vias de sinalização do organismo (GALLAND et al, 2022).…”

Section: -Metodologiaunclassified

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Nanotecnologia: Efeitos Do Uso De Nanopartículas Em Doenças Neurodegenerativas

Barros,

Ribeiro,

Martins

et al. 2024

REASE

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Objetivos: Nos últimos anos vários estudos estão focando na utilização de nanopartículas com compostos bioativos no tratamento de doenças neurodegenerativas, visto que esses compostos bioativos são capazes de combater os efeitos deletérios da neuroinflamação e do estresse oxidativo. As nanopartículas vêm como alternativa para proteger os compostos contra danos proteolíticos e melhorar a sua eficácia na entrega e na atividade biológica. Este trabalho tem como objetivo realizar uma revisão bibliográfica sobre levantamento de dados e resultados de testes que utilizaram nanopartículas no combate de doenças neurodegenerativas. Metodologia: Foram utilizados sites de busca, como, SCIELO, PUBMED e SCIENCE, através das palavras-chave: resumos, nanopartículas, nanobiotecnologia, neuroinflamação e compostos bioativos. Resultados: A partir da busca tivemos bons resultados sobre o uso de nanopartículas em doenças neurodegenerativas, destacamos três achados relevantes e conforme as pesquisas encontramos um estudo sobre o efeito das nanopartículas contendo peptídeos bioativos sobre os processos neuroinflamatórios e estresse oxidativo, onde mostraram resultados promissores, uma vez que os peptídeos bioativos podem combater a neuroinflamação através da interação com os receptores imunológicos nas células cerebrais e/ou vias inflamatórias a jusante. E também achados por Coelho, G (2019), em seus experimentos sobre o efeito da indometacina intercalada em nanopartícula de hidróxido duplo lamelar (HDL) em modelo de neuroinflamação subaguda induzida por lipopolissacarídeo (LPS), foi capaz de recuperar mais rapidamente os efeitos deletérios induzidos pelo LPS. Em outro achado, buscas feitas por Dewey, R (2024), testou nanopartículas de ouro e comprovou um efeito promissor na reversão de déficits cerebrais na esclerose múltipla e Parkinson. Conclusões: De acordo com os estudos, observa-se que a utilização de nanopartículas no combate a seus efeitos neurovegetativos é eficaz, uma vez que esta revisão bibliográfica obteve resultados relevantes através de pesquisas de alto impacto comprovando a eficácia da mesma. Estes achados contribuem para os avanços da ciência e melhora da saúde pública.

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Section: -Metodologiaunclassified

Nanotecnologia: Efeitos Do Uso De Nanopartículas Em Doenças Neurodegenerativas

Barros,

Ribeiro,

Martins

et al. 2024

REASE

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“…[1] These come from the breakdown of proteins and can have between two to 20 amino acids (>6000 Da) in their structure. [2,3] The bioactive peptides can be released from the protein's primary structure through digestive enzymes, which can occur by simulated digestion (in vitro conditions) or the gastrointestinal tract. [4] When the bioactive peptides are consumed or released from gastrointestinal digestion, these can be absorbed from the gut and transported into blood circulation to target sites where these exert their effects.…”

Section: Introductionmentioning

confidence: 99%

“…[4] When the bioactive peptides are consumed or released from gastrointestinal digestion, these can be absorbed from the gut and transported into blood circulation to target sites where these exert their effects. [2,3,5] The bioactive peptides can be obtained from plants (grains, legumes, cereals, fruits, vegetables), animals (meat, milk, fish, eggs, fish), seaweeds, and mushrooms. [3,5] The health benefits of bioactive peptides include antimicrobial, antithrombotic, anticancer, antihypertensive, and other bioactivities.…”

Section: Introductionmentioning

confidence: 99%

Bioactive peptides against angiotensin‐converting enzyme I: An in silico study

Alvíz‐Amador,

Contreras‐Puentes,

Márquez‐Lázaro

2023

Peptide Science

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Bioactive peptides are currently emerging as nonpharmacological alternatives for treating noncommunicable diseases, including hypertension. Pharmacological treatments for hypertension typically involve angiotensin I converting enzyme inhibitors such as Captopril and enalapril. This study aimed to evaluate the activity of bioactive peptides derived from food sources against this enzyme and show its possible mechanism of inhibitory action. A comprehensive search was conducted in peptide databases to identify peptides with antihypertensive properties. Subsequently, docking studies, simulations, and predictive tests assessing ADME parameters, intestinal stability, and allergenicity were performed using bioinformatics tools. The docking and simulation results demonstrated that PEP2 exhibited superior ACE1 inhibitory potential compared to other peptides, even though it had lower human intestinal absorption. In conclusion, this study suggests that these peptides hold promising potential as nutraceuticals for hypertension treatment.

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“…Peptides derived from food proteins have been shown to exhibit diverse bio-modulatory effects in animal and human studies [ 1 , 2 ]. Among the functions of such food-derived peptides, protective effects on the central nervous system have also been reported along with anti-inflammatory and anti-oxidative stress effects, improvement of cognitive function, antidepressant effects, and reductions in the symptoms of neurodegenerative diseases [ 3 , 4 ]. Although the mechanisms underlying the effects of these food-derived peptides vary greatly among tissue/cell types and remain largely unknown, it is assumed that they are mediated via interactions with endogenous target molecules that are present in human or animal tissues/cells.…”

Section: Introductionmentioning

confidence: 99%

Bioinformatics Analysis of the Molecular Networks Associated with the Amelioration of Aberrant Gene Expression by a Tyr–Trp Dipeptide in Brains Treated with the Amyloid-β Peptide

et al. 2023

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Short-chain peptides derived from various protein sources have been shown to exhibit diverse bio-modulatory and health-promoting effects in animal experiments and human trials. We recently reported that the oral administration of the Tyr–Trp (YW) dipeptide to mice markedly enhances noradrenaline metabolism in the brain and ameliorates the working-memory deficits induced by the β-amyloid 25–35 peptide (Aβ25–35). In the current study, we performed multiple bioinformatics analyses of microarray data from Aβ25–35/YW-treated brains to determine the mechanism underlying the action of YW in the brain and to infer the molecular mechanisms and networks involved in the protective effect of YW in the brain. We found that YW not only reversed inflammation-related responses but also activated various molecular networks involving a transcriptional regulatory system, which is mediated by the CREB binding protein (CBP), EGR-family proteins, ELK1, and PPAR, and the calcium-signaling pathway, oxidative stress tolerance, and an enzyme involved in de novo l-serine synthesis in brains treated with Aβ25–35. This study revealed that YW has a neuroprotective effect against Aβ25–35 neuropathy, suggesting that YW is a new functional-food-material peptide.

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Food-derived bioactive peptides: Mechanisms of action underlying inflammation and oxidative stress in the central nervous system

Cited by 17 publications

References 100 publications

Nanotecnologia: Efeitos Do Uso De Nanopartículas Em Doenças Neurodegenerativas

Nanotecnologia: Efeitos Do Uso De Nanopartículas Em Doenças Neurodegenerativas

Bioactive peptides against angiotensin‐converting enzyme I: An in silico study

Bioinformatics Analysis of the Molecular Networks Associated with the Amelioration of Aberrant Gene Expression by a Tyr–Trp Dipeptide in Brains Treated with the Amyloid-β Peptide

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