Food-Derived Natural Compounds for Pain Relief in Neuropathic Pain

Abstract

Neuropathic pain, defined as pain caused by a lesion or disease of the somatosensory nervous system, is characterized by dysesthesia, hyperalgesia, and allodynia. The number of patients with this type of pain has increased rapidly in recent years. Yet, available neuropathic pain medicines have undesired side effects, such as tolerance and physical dependence, and do not fully alleviate the pain. The mechanisms of neuropathic pain are still not fully understood. Injury causes inflammation and immune responses and changed expression and activity of receptors and ion channels in peripheral nerve terminals. Additionally, neuroinflammation is a known factor in the development and maintenance of neuropathic pain. During neuropathic pain development, the C-C motif chemokine receptor 2 (CCR2) acts as an important signaling mediator. Traditional plant treatments have been used throughout the world for treating diseases. We and others have identified food-derived compounds that alleviate neuropathic pain. Here, we review the natural compounds for neuropathic pain relief, their mechanisms of action, and the potential benefits of natural compounds with antagonistic effects on GPCRs, especially those containing CCR2, for neuropathic pain treatment.

Quality Parameters of Mechanically Extracted Edible Macauba Oils (Acrocomia aculeata) for Potential Food and Alternative Industrial Feedstock Application

“…Accordingly to Rodriguez‐Amaya et al and Rufino et al the contents of carotenoids in the mesocarp of A. aculeata surpasses of other tropical fruits. Considering the increasing demand for health‐related natural products from consumers, the nutraceutical potential natural appeal of macauba in its natural state may be considered as one of its remarkable characteristics …”

“…Consumers have shown an increasing demand for natural products which tends to be associated with the health‐related benefits obtained from several classes of bioactive compounds . MUFA, as well as carotenoids, tocopherols, tocotrienols, among other micronutrients, have been related to human blood cholesterol‐lowering as well as to reducing the incidence of coronary heart and various other human diseases .…”

Postoperative pain pathophysiology and treatment strategies after CRS + HIPEC for peritoneal cancer

“…Trauma, infection, cancer, and other conditions could cause neuropathic pain. This can be characterized as spontaneous pain, allodynia (pain response from nonnoxious stimulations), and hyperalgesia (excessive reactions from noxious stimulation) [28,29]. Common histopathological and neurophysiological changes include neurodegeneration, loss of myelinated fibers, and the demyelination of myelinated fibers [30].…”

Analgesic Effects of Cnidium officinale Extracts on Postoperative, Neuropathic, and Menopausal Pain in Rat Models

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