Food-Induced Alterations of Intestinal Permeability in Children with Cowʼs Milk-Sensitive Enteropathy and Atopic Dermatitis

Dupont, Christophe; Barau, E; Molkhou, P.; Raynaud, Florence; Jp, Barbet; Dehennin, L.

doi:10.1097/00005176-198905000-00007

Cited by 103 publications

(60 citation statements)

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“…In Europe, Dupont et al [7] demonstrated an increased intestinal permeability to carbohydrates at diagnosis. Odze et al [8] reviewed colonic biopsy changes: increased inflammatory cells in the lamina propria, lymphoid nodular hyperplasia, and characteristic increase in eosinophilic infiltration of the crypts.…”

Section: Introductionmentioning

confidence: 99%

Dietary protein enterocolitis

Lake

2001

Curr Allergy Asthma Rep

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Section: Introductionmentioning

confidence: 99%

Dietary protein enterocolitis

Lake

2001

Curr Allergy Asthma Rep

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“…Second, the absorbed antigens must evoke harmful immunologic responses. Intestinal permeability has been shown to be increased in CMA patients with gastrointestinal symptoms either at the acute stage of the disease or after a milk challenge, but not on an elimination diet (3,4). These findings might reflect mucosal damage caused by local hypersensitivity mechanisms.…”

mentioning

confidence: 99%

“…These findings might reflect mucosal damage caused by local hypersensitivity mechanisms. In patients with cutaneous symptoms, however, modifications in the intestinal barrier remain elusive (4)(5)(6)(7). Contradictory results may be attributable to different types of immunologic reactions operative in CMA, with varying components of local and systemic responses.…”

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confidence: 99%

Local Immune Response Measured in Blood Lymphocytes Reflects the Clinical Reactivity of Children with Cow's Milk Allergy

Isolauri

Virtanen²,

Jalonen

et al. 1990

Pediatr Res

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ABSTRACT. Study was made of immune responses in cow's milk allergy by a new immunoassay that measures total Ig-secreting cells and specific antibody-secreting cells during their maturation cycle in peripheral blood. These primed gut-associated lymphoid tissue-derived lymphocytes are assumed to reflect the intestinal immune responses. During diagnostic milk provocation, 15 patients had acute urticarial skin eruptions, eight patients had slow onset of eczema, and 15 showed symptoms from the gastrointestinal tract. A significant increase in IgM-secreting cells (means with 95% confidence intervals) from 382.2

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“…Dual sugar intestinal permeability tests are widely used due to their low invasiveness and are considered to be the most valid screening test for the study of the integrity of the small intestinal mucosa in children (18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%

A rapid gas-liquid chromatography method for the determination of lactulose and mannitol in urine: Clinical application in studies of intestinal permeability

Bozá

Romera

Gil

1995

Clinical Biochemistry

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Objective:The purpose of this study was to develop a gas-liquid chromatography method for the determination of the urinary excretion of two nonmetabolizable sugars (lactulose and mannitot) to estimate the intestinal permeability. Methods:Two internal standards (a-methyI-D-glucopyranosyde and sucrose) were added to the urine samples prior to derivatization with the aid of a solution of pyridine, [N, O-bis (trimethylsilyl)]-acetamide and chlorotrimethylsilan. Sample preparation was simpler and faster than in other previous methods and the four sugars were resolved within 27 min. Results:The inclusion of internal standards reduced the coefficient of variation from 9.44% to 4.78%. The method provided better sensitivity, range of analysis, and linearity than a previously published HPLC method reducing variances in the recovery of lactulose and mannitol added to urine. The clinical application of this method was tested in preterm infants fed human milk or cow's milk based formula and in breast fed term infants. Conclusion:The method described here for the determination of urinary lactulose and mannitol is more rapid, simpler, and more accurate than other previously published methods.

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Food-Induced Alterations of Intestinal Permeability in Children with Cowʼs Milk-Sensitive Enteropathy and Atopic Dermatitis

Cited by 103 publications

References 0 publications

Dietary protein enterocolitis

Dietary protein enterocolitis

Local Immune Response Measured in Blood Lymphocytes Reflects the Clinical Reactivity of Children with Cow's Milk Allergy

A rapid gas-liquid chromatography method for the determination of lactulose and mannitol in urine: Clinical application in studies of intestinal permeability

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