Food Intake and Colorectal Cancer

Kumar, Akshaya; Chinnathambi, Shanmugavel; Kumar, Magi; Pandian, Ganesh N.

doi:10.1080/01635581.2023.2242103

Cited by 17 publications

(8 citation statements)

References 259 publications

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“…PSs remain highly unabsorbed at the colon [ 35 ] and perform their antiproliferative effect, targeting cell death in tumoral cells (such as the Caco-2 cell line) without damaging normal epithelial cells (such as the CCD18-Co cell line). Furthermore, the presence of fiber in the digested/fermented samples, with the subsequent formation of SCFA, together with the antioxidants, could have a synergistic action in the antiproliferative effects observed [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…One of the most important risk factors for this disease is diet, which can interfere with colonic microbiota, and increase or reduce the risk of tumor formation. The intake of fruits and vegetables, rich in bioactive compounds (fiber, plant sterols (PSs), phenolic compounds, flavonoids, and sulfur compounds), is related with a lower risk of CRC development [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Chemopreventive Effect of an In Vitro Digested and Fermented Plant Sterol-Enriched Wholemeal Rye Bread in Colon Cancer Cells

Miedes,

Cilla,

Alegría

2023

Foods

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Diet is crucial for the prevention of colorectal cancer. Whole grains are the source of beneficial compounds for this, such as fiber. The enrichment of wholemeal rye bread with plant sterols (PSs) could increase its beneficial effects. This study aimed to assess the potential antiproliferative effect of this enriched food on colon adenocarcinoma cells (Caco-2) compared with a non-enriched one. After a human oral chewing, simulated semi-dynamic gastrointestinal digestion and colonic fermentation in a simgi® system, fermentation liquids (FLs) obtained were used as treatment for cells. Cytotoxicity assay showed that samples diluted 1/5 (v/v) with DMEM are not toxic for non-tumoral cells, whereas they damage tumoral cells. Samples with PS (FLPS) produced a higher chemopreventive effect (vs. blank) in MTT and apoptosis assays, as well as higher gene expression of TP53 and Casp8. Nevertheless, FL0 (without PS) produced a higher chemopreventive effect in a cell cycle and reduced glutathione and calcium assays, besides producing higher gene expression of Casp3 and lower CCND1. The distinct antiproliferative effect of both FLs is attributed to differences in PSs, short chain fatty acids (lower concentration in FLPS vs. FL0) and antioxidant compounds. These results may support wholemeal rye bread consumption as a way of reducing the risk of colorectal cancer development, although further research would be needed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemopreventive Effect of an In Vitro Digested and Fermented Plant Sterol-Enriched Wholemeal Rye Bread in Colon Cancer Cells

Miedes,

Cilla,

Alegría

2023

Foods

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“…It has been shown that the consumption of carotenoids such as lycopene and β-carotene, particularly abundant in carrots, pumpkins, and tomatoes, are important protective factors that prevent the onset and reduce the risk of CRC [ 203 ]. Furthermore, the consumption of green tea has also demonstrated a preventive action on colorectal cancer due to the action of important polyphenols such as catechins and epicatechins [ 204 ]. Studies have shown that the consumption of a moderate quantity of red wine protects the individual from the development of CRC thanks to the antioxidant and anti-proliferative action of resveratrol, an important polyphenol belonging to the stilbene class [ 205 ].…”

Section: Lifestyle and Colorectal Cancermentioning

confidence: 99%

Healthy Lifestyle and Cancer Risk: Modifiable Risk Factors to Prevent Cancer

Marino,

Mininni,

Deiana

et al. 2024

Nutrients

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Cancer has become a serious problem worldwide, as it represents the main cause of death, and its incidence has increased over the years. A potential strategy to counter the growing spread of various forms of cancer is the adoption of prevention strategies, in particular, the use of healthy lifestyles, such as maintaining a healthy weight, following a healthy diet; being physically active; avoiding smoking, alcohol consumption, and sun exposure; and vitamin D supplementation. These modifiable risk factors are associated with this disease, contributing to its development, progression, and severity. This review evaluates the relationship between potentially modifiable risk factors and overall cancer development, specifically breast, colorectal, and prostate cancer, and highlights updated recommendations on cancer prevention. The results of numerous clinical and epidemiological studies clearly show the influence of lifestyles on the development and prevention of cancer. An incorrect diet, composed mainly of saturated fats and processed products, resulting in increased body weight, combined with physical inactivity, alcohol consumption, and smoking, has induced an increase in the incidence of all three types of cancer under study. Given the importance of adopting correct and healthy lifestyles to prevent cancer, global institutions should develop strategies and environments that encourage individuals to adopt healthy and regular behaviors.

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“…Therefore, it is vital to maintain adequate Mg levels in the body [ 78 ]. With effective magnesium supplementation, the formation and recurrence of colorectal carcinoma can be prevented [ 79 , 80 , 81 , 82 ]. Other studies have found that an increase in the incidence of hepatocellular carcinoma can be attributed mainly to the presence of non-alcoholic fatty liver disease (NAFLD).…”

Section: Hypomagnesemia and Cancermentioning

confidence: 99%

Magnesium Is a Vital Ion in the Body—It Is Time to Consider Its Supplementation on a Routine Basis

Pethő,

Fülöp,

Orosz

et al. 2024

Clinics and Practice

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The importance of maintaining proper magnesium intake and total body magnesium content in preserving human health remains underappreciated among medical professionals and laymen. This review aimed to show the importance of hypomagnesemia as a modifiable risk factor for developing disease processes. We searched the PubMed database and Google Scholar using the keywords ‘magnesium’, ‘diabetes’, ‘cardiovascular disease’, ‘respiratory disease’, ‘immune system’, ‘inflammation’, ‘autoimmune disease’, ‘neurology’, ‘psychiatry’, ‘cognitive function’, ‘cancer’, and ‘vascular calcification’. In multiple contexts of the search terms, all reviews, animal experiments, and human observational data indicated that magnesium deficiency can lead to or contribute to developing many disease states. The conclusions of several in-depth reviews support our working hypothesis that magnesium and its supplementation are often undervalued and underutilized. Although much research has confirmed the importance of proper magnesium supply and tissue levels, simple and inexpensive magnesium supplementation has not yet been sufficiently recognized or promoted.

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Food Intake and Colorectal Cancer

Cited by 17 publications

References 259 publications

Chemopreventive Effect of an In Vitro Digested and Fermented Plant Sterol-Enriched Wholemeal Rye Bread in Colon Cancer Cells

Chemopreventive Effect of an In Vitro Digested and Fermented Plant Sterol-Enriched Wholemeal Rye Bread in Colon Cancer Cells

Healthy Lifestyle and Cancer Risk: Modifiable Risk Factors to Prevent Cancer

Magnesium Is a Vital Ion in the Body—It Is Time to Consider Its Supplementation on a Routine Basis

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