Food protein–induced enterocolitis syndrome

Hoffmann, Natalie V.; Ahmed, Aisha Siddiqah; Fortunato, John E.

doi:10.1016/j.anai.2021.02.004

Cited by 15 publications

(3 citation statements)

References 58 publications

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“…It acts on central nervous system and peripheral nerves and its efficacy in FPIES suggests a neuroimmune mechanism in addition to the immune-mediated one. A dysregulation or limited compensation of the autonomic nervous system, depending on cytokine release and gastrointestinal losses, may be responsible for the exaggerated cardiovascular response and lethargy [87]. Immune cells are able to synthesize serotonin; in addition, mast and enterochromaffin cells have been identified as a source of gastrointestinal serotonin release [88].…”

Section: Management Of Dies In Childrenmentioning

confidence: 99%

Drug-Induced Enterocolitis Syndrome in Children

Filippo

Venanzi

Ciarelli

et al. 2023

IJMS

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Drug-Induced Enterocolitis Syndrome (DIES) is a drug-induced hypersensitivity reaction non-IgE mediated involving the gastrointestinal system that occurs 2 to 4 h after drug administration. Antibiotics, specifically amoxicillin or amoxicillin/clavulanate, represent the most frequent drugs involved. Symptoms include nausea, vomiting, abdominal pain, diarrhea, pallor, lethargy, and dehydration, which can be severe and result in hypovolemic shock. The main laboratory finding is neutrophilic leukocytosis. To the best of our knowledge, 12 cases of DIES (9 children-onset and 3 adult-onset cases) were described in the literature. DIES is a rare clinically well-described allergic disease; however, the pathogenetic mechanism is still unclear. It requires to be recognized early and correctly treated by physicians.

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Section: Management Of Dies In Childrenmentioning

confidence: 99%

Drug-Induced Enterocolitis Syndrome in Children

Filippo

Venanzi

Ciarelli

et al. 2023

IJMS

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“…Atypical – involves the appearance of sIgE to the triggering food, and 25% of patients develop a food allergy [ 20 ].…”

Section: Fpies In Adultsmentioning

confidence: 99%

Food protein induced enterocolitis syndrome in adults

Kuźmiński¹,

Przybyszewska²,

Bartuzi³

2023

pdia

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Food protein induced enterocolitis syndrome (FPIES) belongs to a group of IgE-independent food allergies. It is the domain of paediatric patients, but it can also occur in adults. In this disease there is a life-threatening risk resulting from the possibility of a severe course of the disease and the development of hypovolemic shock. The disease was first defined in the mid-1970s. Knowledge about this disease is extremely low, we do not know its exact frequency, and the disease itself usually appears between 2 and 7 months of age. FPIES occurs mainly in formula-fed infants, typically 1-4 weeks after formula introduction, very rarely in breastfed infants, but may also develop in adults.

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“…The classic examples include food protein-induced allergic proctocolitis (FPIAP), a benign condition generally presenting in early infancy, and food protein-induced enterocolitis syndrome (FPIES), generally presenting with severe symptoms within the first 6 months of life [ 85 ]. While not completely characterized, FPIES results from food-induced immune activation, including activation of the innate immune system limited to the gastrointestinal tract [ 86 , 87 ]. FPIES is associated with disruption or a lack of development of tolerance [ 84 ].…”

Section: Allergy and Functional Abdominal Pain Disordersmentioning

confidence: 99%

Update on the Role of Allergy in Pediatric Functional Abdominal Pain Disorders: A Clinical Perspective

2021

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Both functional abdominal pain disorders (FAPDs) and food allergies are relatively common in children and adolescents, and most studies report an association between FAPDs and allergic conditions. FAPDs share pathophysiologic processes with allergies, including both immune and psychological processes interacting with the microbiome. No conclusive data are implicating IgE-mediated reactions to foods in FAPDs; however, there may be patients who have IgE reactions localized to the gastrointestinal mucosa without systemic symptoms that are not identified by common tests. In FAPDs, the data appears stronger for aeroallergens than for foods. It also remains possible that food antigens initiate an IgG reaction that promotes mast cell activation. If a food allergen is identified, the management involves eliminating the specific food from the diet. In the absence of systemic allergic symptoms or oral allergy syndrome, it appears unlikely that allergic triggers for FAPDs can be reliably identified by standard testing. Medications used to blunt allergic reactions or symptomatically treat allergic reactions may be useful in FAPDs. The purpose of the current manuscript is to review the current literature regarding the role of allergy in FAPDs from a clinical perspective, including how allergy may fit in the current model of FAPDs.

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Food protein–induced enterocolitis syndrome

Cited by 15 publications

References 58 publications

Drug-Induced Enterocolitis Syndrome in Children

Drug-Induced Enterocolitis Syndrome in Children

Food protein induced enterocolitis syndrome in adults

Update on the Role of Allergy in Pediatric Functional Abdominal Pain Disorders: A Clinical Perspective

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