Food Protein-Induced Enterocolitis Syndrome

Shock in a Newborn: A Rare Cause

“…6 FPIES is a diagnosis of exclusion and the differential diagnosis of FPIES is broad, encompassing multiple gastrointestinal, metabolic, allergic, infectious, cardiovascular, and neurologic disorders. 1,10…”

“…6 FPIES is a diagnosis of exclusion and the differential diagnosis of FPIES is broad, encompassing multiple gastrointestinal, metabolic, allergic, infectious, cardiovascular, and neurologic disorders. 1,10 To date, the elimination of the causative food from the diet of the patient is the only therapy for FPIES. The treatment of acute FPIES is mainly supportive with continued fluid resuscitation.…”

Food protein–induced enterocolitis and alpha-1-antitrypsin deficiency

“…Since publication of the guidelines, numerous additional publications have also erroneously included alpha-1-antitrypsin deficiency as a potential cause of FPIES-like symptoms. [4][5][6][7][8] This letter should not detract in any way from the outstanding efforts of the FPIES workgroup but merely serves to inform and mitigate potentially unnecessary workup. The propagation of alpha-1-antitrypsin deficiency in the differential diagnosis of FPIES also serves as a reminder of how, like a game of ''telephone,'' the medical literature can be gradually misrepresented over time and emphasizes the importance of checking citations for accuracy and referring to primary sources.…”

Food protein-induced enterocolitis syndrome – a little-known form of non-IgE-mediated food hypersensitivity

“…Non-IgE-mediated type of food allergy plays an important role. FPIES is a relatively rare disease and epidemiological data are lacking [4]. A study conducted in Israel on a cohort of 13,000 infants showed an incidence of FPIES triggered by cow's milk protein of 0.34%, compared to 0.5% for IgE-mediated allergy to cow's milk protein [5].…”

“…A study conducted in Israel on a cohort of 13,000 infants showed an incidence of FPIES triggered by cow's milk protein of 0.34%, compared to 0.5% for IgE-mediated allergy to cow's milk protein [5]. Studies report a male predominance (as it is with IgE-mediated food allergy); there is an increased incidence of FPIES and atopic diseases in children and their families [4]. There is no strong familial association in both parents and siblings, in contrast to eosinophilic oesophagitis [6].…”