Food Protein-Induced Enterocolitis Syndrome in Children with Down Syndrome: A Pilot Case-Control Study

Okazaki, Fumiko; Wakiguchi, Hiroyuki; Korenaga, Yuno; Takahashi, Kazumasa; Yasudo, Hiroki; Fukuda, Ken; Shimokawa, Mototsugu; Hasegawa, Shunji

doi:10.3390/nu14020388

Cited by 6 publications

(2 citation statements)

References 30 publications

(47 reference statements)

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“…Here, Morita et al classification method was used: 1) “IgE-mediated,” 2) “non-IgE-mediated and 3) “combined IgE- and cell-mediated” [47]. Here, using C57BL/6 mice, no peanut-specific IgE was found (data not shown), thus correlating to a Non–IgE-mediated food allergy [48, 49]. Furthermore, other studies from our group have shown that our mouse model does not induce IgE in C57BL/6 mice, only in Balb/c mice [50].…”

Section: Discussionmentioning

confidence: 99%

Expansion of Antigen- Specific Memory Cells as a Potential Booster for Food Tolerance Induction

Silva¹,

Marmello²,

Bentes³

et al. 2023

Preprint

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Approximately 3% of children in Western countries are diagnosed with peanut allergy, a likely lifelong disease. The preferred treatment for food allergy is allergen avoidance. However, oral immunotherapy is an FDA-approved treatment to re-induce tolerance, still, not all patients respond as expected. Thus, the aim of this work is to evaluate whether the association of an antigen-specific tolerogenic (oral tolerance) bystander effect can ameliorate the recovery of inflamed intestinal mucosa. Adult male C57BL/6 mice were divided into five groups, four of which were submitted to an intestinal inflammation induction protocol to peanuts. After sensitization, experimental groups were orally challenged with either peanuts or a hybrid diet (peanuts + mouse chow). In a second stage, groups were sensitized, challenged with peanuts, and then received either peanuts, hybrid diet, or ovalbumin chow during the recovery period of the inflamed mucosa. Results showed no changes in diet intake and body weight. Polyisotypic anti-peanut IgG and IgG1 were significantly increased in the serum from animals in allergic groups. The group that received the hybrid diet showed an increase in CD4+CD25+Foxp3+ regulatory T cells, as well as in B220+CD3-CD27+ memory B cells. Histology of the duodenum showed a decrease in intraepithelial leukocytes in animals who received hybrid diet. Together, our results show that when the tolerogen is added to a diet containing the allergen, it can ameliorate the induction of local inflammation. Simultaneously offering the allergen with a tolerated food increased the mucosal recovery due to the expansion of previously induced memory cells.

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Section: Discussionmentioning

confidence: 99%

Expansion of Antigen- Specific Memory Cells as a Potential Booster for Food Tolerance Induction

Silva¹,

Marmello²,

Bentes³

et al. 2023

Preprint

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show abstract

“…The involvement of antigen-specific T cells and their production of proinflammatory cytokines were found to be associated with regulation of the permeability of the intestinal barrier as leading to damage of the barrier and causing high amount of food allergens penetrating into the lamina propria. It was also found that humoral immune responses also contributed to the pathophysiology of FPIES as detecting lower levels of antigen-specific IgE, IgA, and IgG4 in patients with FPIES compared with those in patients with resolved FPIES [3].…”

Section: Introductionmentioning

confidence: 98%

Evaluation of the Clinical Characteristics of Patients with Food Protein-Induced Enterocolitis Syndrome: A Multicenter Study

Metbulut

Özen

Kendirci

et al. 2022

Int Arch Allergy Immunol

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Introduction: Food protein-induced enterocolitis syndrome (FPIES) is a rare non-IgE, cell-mediated food allergy disorder. We aimed to report the demographic characteristics, clinical features, and management of pediatric patients with FPIES. Methods: This retrospective study included all children diagnosed with FPIES at the pediatric allergy departments of the participating twelve study centers from January 2015 to November 2020. Results: A total of 73 patients (39 males, 53.4%) with a male/female ratio of 1.1 were included in the study. The median (interquartile ranges) age at symptom onset was 6 months (0.5–168, 4–9.5). The most frequent offending foods were cow’s milk, egg’s yolk, fish, and egg’s white, identified in 38.4% (n = 28), 32.9% (n = 24), 21.9% (n = 16) and 20.5% (n = 15) of the patients, respectively. The total number of reported FPIES episodes was 290 (3.9 episodes per child). Oral food challenge (OFC) was performed in 54.8% (n = 40) of the patients, and tolerance was detected in 17 OFCs (42.5%) at a median age of 15 months (range 8–132 months). Conclusion: FPIES is a non-IgE-mediated food hypersensitivity that commonly affects infants and is often misdiagnosed. The pathophysiology of the disease remains unclear and the low awareness of FPIES among physicians and parents highlights the need for more education.

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Food allergy and intolerance in developmental disorders

Williams¹,

Erdle²

2024

Encyclopedia of Food Allergy

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Food Protein-Induced Enterocolitis Syndrome in Children with Down Syndrome: A Pilot Case-Control Study

Cited by 6 publications

References 30 publications

Expansion of Antigen- Specific Memory Cells as a Potential Booster for Food Tolerance Induction

Expansion of Antigen- Specific Memory Cells as a Potential Booster for Food Tolerance Induction

Evaluation of the Clinical Characteristics of Patients with Food Protein-Induced Enterocolitis Syndrome: A Multicenter Study

Food allergy and intolerance in developmental disorders

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