Food restriction reduces cortical bone mass and serum insulin-like growth factor-1 levels and promotes uterine atrophy in mice

Ito, Eri; Sato, Yuiko; Kobayashi, Tami; Kaneko, Yosuke; Soma, Tomoya; Matsumoto, Tatsuaki; Kimura, Atushi; Miyamoto, Kana; Matsumoto, Hideo; Matsumoto, Morio; Nakamura, Masaya; Sato, Kazuki; Miyamoto, Takeshi

doi:10.1016/j.bbrc.2020.11.122

Cited by 6 publications

(3 citation statements)

References 24 publications

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“…The mechanism underlying elevated serum calcium and famine in early life is unclear; it might be related to enhanced bone resorption during famine exposure. In rodents, food restriction reduces cortical bone mass and cortical thickness while trabecular percent bone volume (BV/TV) was significantly lower in the food restriction group ( 56 – 58 ). Moreover, there is an increase in osteoclasts number and bone resorption in caloric restriction mice ( 59 , 60 ), which is in line with the previous hypothesis that bone resorption activity was enhanced during famine exposure.…”

Section: Discussionmentioning

confidence: 99%

Association of famine exposure and the serum calcium level in healthy Chinese adults

Yang

Deng²,

Ma³

et al. 2022

Front. Endocrinol.

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ObjectiveFamine exposure and higher serum calcium levels are related with increased risk of many disorders, including Alzheimer’s disease, atherosclerosis, diabetes, and osteoporosis. Whether famine exposure has any effect on serum calcium level is unclear. Besides, the normal reference range of serum calcium is variable among different populations. Our aims are 1) determining the reference interval of calcium in Chinese adults; 2) exploring its relationship with famine exposure.MethodsData in this study was from a cross-sectional study of the epidemiologic investigation carried out during March-August 2010 in Jiading district, Shanghai, China. Nine thousand and two hundred eleven participants with estimated glomerular filtration rate (eGFR) ≥60ml/min/1.73m2 were involved to calculate reference interval of total calcium from 10569 participants aged 40 years or older. The analysis of famine exposure was conducted in 9315 participants with complete serum biochemical data and birth year information.ResultsAfter rejecting outliers, the 95% reference interval of total serum calcium was 2.122~2.518 mmol/L. The equation of albumin-adjusted calcium was: Total calcium + 0.019* (49-Albumin), with a 95% reference interval of 2.151~2.500 mmol/L. Compared to the age-balanced control group, there was an increased risk of being at the upper quartile of total serum calcium (OR=1.350, 95%CI=1.199-1.521) and albumin-adjusted calcium (OR=1.381, 95%CI=1.234-1.544) in subjects experienced famine exposure in childhood. Females were more vulnerable to this impact (OR= 1.621, 95%CI= 1.396-1.883 for total serum calcium; OR=1.722, 95%CI= 1.497-1.980 for albumin-adjusted calcium).ConclusionsFamine exposure is an important environmental factor associated with the changes in circulating calcium concentrations, the newly established serum calcium normal range and albumin-adjusted calcium equation, together with the history of childhood famine exposure, might be useful in identifying subjects with abnormal calcium homeostasis and related diseases, especially in females.

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Section: Discussionmentioning

confidence: 99%

Association of famine exposure and the serum calcium level in healthy Chinese adults

Yang

Deng²,

Ma³

et al. 2022

Front. Endocrinol.

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“…In FR experiments, mice housed in individual cages were randomly divided into four groups. As in a previous experiment 25 , the "ad" group consumed the CE-2 diet ad libitum; the "FR" group consumed 60% of that based on the average intake of the ad libitum group; the "ad+ex" group consumed food ad libitum and did running exercise; and the "FR+ex" group was 60% food-restricted and performed voluntary running exercise. Both "ad+ex" and "FR+ex" groups had free access to a running wheel (circumference 0.45m, width 60, φ140 mm) in their cages for voluntary running exercise, while "ad" and "FR" groups did not.…”

Section: Methodsmentioning

confidence: 99%

“…Among characteristics of the female athlete triad, low energy availability is the most upstream 3,24 . In fact, low energy availability model female mice show signi cant uterine atrophy and decreased bone mass and strength 25 . Functional hypothalamic amenorrhea is also reportedly upstream of osteoporosis in humans 26 , and female functional hypothalamic amenorrhea model mice exhibit reduced bone mass 27 .…”

Section: Introductionmentioning

confidence: 99%

Low energy availability reduces bone mass and gonadal function in male mice

et al. 2023

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In women, the female athlete triad, marked by low energy availability, functional hypothalamic amenorrhea and osteoporosis, is a recognized risk for stress fractures. Stress injuries also occur in men, but by contrast risks and mechanisms underlying them are less characterized. Here we propose that low energy availability puts men at risk for stress injuries as well. Male low energy availability model mice, established by limiting food intake, exhibited signi cantly reduced testicle weight, serum testosterone levels and bone mass. Such losses in bone mass were enhanced by exercise in food-restricted (FR) male mice. Histological analysis revealed that both bone-resorbing and -forming activities were signi cantly reduced in FR or FR plus exercise (FR+ex) mice, mimicking a state of low bone turnover. Signi cantly reduced bone mass in FR or FR+ex male mice was signi cantly rescued by treatment with 1,25(OH) 2 D 3 (1.25) or ED71 (ED), both active vitamin D analogues, with signi cant restoration of osteoblastic activities. Serum levels of insulin-like growth factor I (IGF-I), which activates osteoblastic activities and is critical for bone remodeling, were signi cantly lower in FR versus control male mice, but restored by administration of either of vitamin D analogue. However, administration of recombinant IGF-I did not rescue reduced bone mass in FR male mice, and administration of either active vitamin D analogue could increase bone mass even in IGF-I conditional knockout FR male mice. Taken together, conditions comparable to the female athlete triad are also a risk for male stress injuries, and low energy availability is upstream of gonadal dysfunction and osteoporosis in males. Active vitamin D analogues could serve as therapeutic or preventive options for stress injuries in men.

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Dietary restriction plus exercise change gene expression of Cxcl12 abundant reticular cells in female mice

Ikedo,

Imai

2024

J Bone Miner Metab

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Food restriction reduces cortical bone mass and serum insulin-like growth factor-1 levels and promotes uterine atrophy in mice

Cited by 6 publications

References 24 publications

Association of famine exposure and the serum calcium level in healthy Chinese adults

Association of famine exposure and the serum calcium level in healthy Chinese adults

Low energy availability reduces bone mass and gonadal function in male mice

Dietary restriction plus exercise change gene expression of Cxcl12 abundant reticular cells in female mice

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