Food safety: how analytical chemists ensure it

Romero‐González, Roberto

doi:10.1039/c5ay00263j

Cited by 23 publications

(11 citation statements)

References 50 publications

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“…11 Recently, publications have shown a clear trend towards wide-scope multiclass compound analysis such as pesticides, mycotoxins, natural plant toxins, 12 and multiple organic contaminants with over 625 targeted compounds. 13,14 In addition to the diversity of constituents, a variety of sample matrices are being covered from food, 15 samples from the body such as urine 16 and blood, 17 to environmental samples, e.g. air and water.…”

Section: Introductionmentioning

confidence: 99%

Towards the use of ion mobility mass spectrometry derived collision cross section as a screening approach for unambiguous identification of targeted pesticides in food

Goscinny

McCullagh

Far

et al. 2019

Rapid Comm Mass Spectrometry

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Rationale Mass spectrometry (MS) is the reference method for the screening of ultra‐trace residues of pesticides in food because MS offers the required selectivity/sensitivity to gather information and enable the analyst to make informed decisions during the identification process. Here we present and discuss the use of collision cross section (CCS) values in addition to mass accuracy and retention times in a pesticide screening method that integrates all the features offered by coupling ultra‐performance liquid chromatography (UPLC) with ion mobility mass spectrometry (IMS‐MS). Methods All experiments were carried out using UHPLC coupled to a travelling wave ion mobility mass spectrometer equipped with an electrospray ionization (ESI) source working in positive mode. An in‐house library containing 200 pesticides was built using standard solutions and used as reference for a TWCCS calibration study. Matrix extracts were analyzed to evaluate the performance of different screening workflows based on TWCCS, mass accuracy and retention times. Results The results proved that TWCCS values are very consistent, as the measured values do not differ more than 1% from the in‐house reference data library and emphasized the importance of the first low m/z mobility calibration point to guarantee full independence from instrument parameters and calibrant. The screening procedure was simplified to a single step by fully exploiting the content of ion mobility without generating any false detections, either positive or negative, from spiked samples and a previous proficiency test. Conclusions The screening approach proposed in this study is unconventional and based on large mass accuracy (20 ppm) and retention time windows (0.5 min) to capture, in a first step, a maximum of detected compounds. Compounds of interest are then identified by comparing measured collision cross sections with the measured reference library collision cross sections (with relative error tolerance lower than 2%).

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Section: Introductionmentioning

confidence: 99%

Towards the use of ion mobility mass spectrometry derived collision cross section as a screening approach for unambiguous identification of targeted pesticides in food

Goscinny

McCullagh

Far

et al. 2019

Rapid Comm Mass Spectrometry

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“…The new platforms for advanced food analysis are required, as the food value chain becomes increasingly complex and global in recent years (Aydoğan, 2019; Romero‐González, 2015; Weng & Neethirajan, 2017). Several classes of antibiotics are used for veterinary medicine.…”

Section: Introductionmentioning

confidence: 99%

ProFlow nano‐liquid chromatography with a graphene oxide‐functionalized monolithic nano‐column for the simultaneous determination of chloramphenicol and chloramphenicol glucuronide in foods

Demir

Aydoğan

2022

Journal of Food Science

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Chloramphenicol (CAP) is an effective antibiotic with broad spectrum against gram‐positive and gram‐negative bacteria, while it is used to treat various infections in animals. Although CAP is banned for usage in the livestock products including, milk, honey, seafood, and royal jelly, CAP is still often detected in foods of animal origin, posing a threat to consumer health. The use of CAP is restricted in many countries due to its side effect in human metabolic process according to the Expert Committee on Food Additives (ECFA) recommendation. Chloramphenicol glucuronide (CAPG) is also a metabolic product of CAP, which may be a hazardous chemical for human health. Therefore, the development of sensitive separation and quantification method is an important issue, especially for food safety. Herein, we reported the preparation and application of a monolithic nano‐column for CAP and CAPG analyses in foods by ProFlow Nano liquid chromatography (ProFlow Nano LC). The monolithic nano‐column was prepared by an in situ polymerization using 3‐chloro‐2‐hydroxypropylmethacrylate (HPMA‐Cl) and ethylene dimethacrylate (EDMA) and followed graphene oxide (GO) modification. After characterization, the monolithic nano‐column was used for the analysis of CAP and CAPG in honey and milk samples by ProFlow Nano LC. The whole method was validated in terms of linearity, sensitivity, precision, recovery, and repeatability, while it led to obtain high sensitivity with limit of quantification was found as 0.02 µg/kg for CAP. Limit of quantification for CAPG was found as 0.08 µg/kg. The developed method with monolithic nano‐column was optimized to achieve very sensitive analyses of CAP and CAPG in the food samples. The applicability of the nano‐column was successfully demonstrated by the analysis of CAP and CAPG in milk and honey samples. Practical Application This article describes the preparation and application of a monolithic nano‐column for the separation and determination of chloramphenicol and chloramphenicol glucuronide in food samples by ProFlow Nano LC. The use of new and advanced techniques is a crucial issue in the food science and technology. In this sense, this study demonstrated a new food analysis method using advanced instrumental technique with a homemade monolithic nano‐column.

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“…The Maximum Residue Limits (MRL) of any active substance is of importance at the international level for different reasons including legal requirements (Villaverde et al, 2016), and trade barriers (Xiong & Beghin, 2014;Yeung et al, 2017). Establishing MRLs increases costs due to the requirement for sampling (Fleming et al, 2017), establishing analytical methods (Romero-González, 2015) and subsequent routine analyses (De Brabander et al, 2011). But, at the same time, the demand for pesticide survey and monitoring is increasing (Pedersen et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

The major interest for crop protection of agrochemical substances without maximum residue limit (MRL)

Charon¹,

Robin²,

Marchand³

2019

Biotechnol. Agron. Soc. Environ.

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Description of the subject. The real-time management of residues of plant protection products is a general issue for food producers and/or exporters. Authorized pesticides under European Regulation (EC) No 1107/2009 (Reg. 1107/2009) are granted a maximum residue limit (MRL) defined by the European Chemicals Agency (ECHA). These maximum residue limits are managed by the European Commission and listed in EC Regulation No 396/2005. MRLs for newly approved substances are set for pesticide residues present in products or groups of products covered by Annex I with a default value of 0.01 mg·kg-1, unless they have been considered, elaborated upon on approval and affected in one of the six other Annexes (II to VII). Substances listed in Annex IV are favoured in the selection of substances to be used by producers as it is for substances with very low potential impacts (low-risk substances [Art. 22 of Reg. 1107/2009] which therefore require no MRL; basic substances [Art. 23 of Reg. 1107/2009]; and microorganisms). The number of substances affected by this lack of an MRL (without residues survey requirement) has been steadily increasing since the publication of the SANCO/11188/2013 Guideline. Many biocontrol agents are listed in Annex IV, including microbial insecticides (e.g. Bacillus thuringiensis, Cydia pomonella granulosis virus), semiochemicals used in traps (e.g. ammonium acetate, putrescine) and some natural substances (e.g. sulphur) as well as all the currently listed basic substances. Objectives. To show that plant protection may be achieved with less concern or control (auto + external) than with certain agrochemical pesticides, including those without maximum residue limits (MRL). Method. Analysis of EU Pesticide Database and EU Regulation (EU) No 540/2011. Results. All approved pesticide active substances with no MRL included in Annex IV of Regulation (EC) No 396/2005, listed by substance status type (active, low-risk or basic) and category (microorganism, semiochemical or natural). Conclusions. These results may be used to help achieve plant protection with much less risk of contaminations, while noting the necessity for controls, analytical issues, positive controls, as well as the possibility of downgrading and withdrawal of approval from the market.

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Food safety: how analytical chemists ensure it

Abstract: Nowadays consumer concerns related to food safety are increasing and analytical chemists should provide suitable analytical tools to fulfil international legislation and ensure that foodstuff is adequate to be consumed.

Cited by 23 publications

References 50 publications

Towards the use of ion mobility mass spectrometry derived collision cross section as a screening approach for unambiguous identification of targeted pesticides in food

Towards the use of ion mobility mass spectrometry derived collision cross section as a screening approach for unambiguous identification of targeted pesticides in food

ProFlow nano‐liquid chromatography with a graphene oxide‐functionalized monolithic nano‐column for the simultaneous determination of chloramphenicol and chloramphenicol glucuronide in foods

The major interest for crop protection of agrochemical substances without maximum residue limit (MRL)

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