Introduction. Currently, Ethiopia, in particular, the rural areas of Ethiopia, faces high levels of food insecurity. In spite of the fact that there have been many studies on food security, most of them have been conducted in specific national settings. Hence, the determinants of food insecurity should be assessed at the national level. Therefore, this study was primarily aimed to identify the determinant factors of household food insecurity in rural Ethiopia. Method. A cross-sectional Ethiopian socioeconomic survey (ESS) data collected from September 2018 to August 2019 was utilized. A sample of 3115 households was selected from 316 clusters across rural Ethiopia using a two-stage probability sampling technique. To identify the determinants of food insecurity, logistic regression was applied. Results. Among 3,115 households, 50.05% of them were food insecure. Factors such as the household head being aged from 30 to 64 (AOR = 0.786, 95% CI: [0.635, 0.973]), widowed, divorced, or separated (AOR = 1.588, 95%CI: [1.001, 2.518]), literate (AOR = 0.702, 95%CI: [0.590, 0.834]), household aid (AOR = 1.339, 95%CI: [1.089, 1.648]), drought-affected (AOR = 0.640, 95%CI: [0.507, 0.808]), nonagricultural business (AOR = 0.655, 95%CI: [0.472, 0.908]), dependency ratio from 50 to 75% (AOR = 0.680, 95%CI: [0.534, 0.867]), having 6 to 10 livestock (AOR = 0.644, 95%CI: [0.496, 0.836]), and more than 10 livestock (AOR = 0.362, 95% CI: [0.284, 0.461]) were found to be significantly associated with the household’s food insecurity at 5% level of significance. Conclusion. The household head’s age from 30 to 64, being literate, drought-affected, having nonagricultural business, dependency ratio from 50 to 75%, and owning more than 10 livestock have been negatively affecting food insecurity. While supporting households, a “widowed, divorced, or separated” household head has had a positive effect on food insecurity in rural Ethiopia positively influencing food insecurity in rural Ethiopia. Policymakers need to pay special attention to very young and old-aged household heads, adult education, household self-help, livestock improvement, and entrepreneurship while implementing poverty reduction programs.