Foot-and-Mouth Disease Virus: Stability of Neutralizing Antibody After Freeze-drying and Air-drying

Next Generation Drying Technologies for Pharmaceutical Applications

“…Yeast, 29 probiotics, 30 proteins, 31,32 antibodies, 33 enzymes, 34 platelets, 35 fish, 36 encountered in developing an efficient drying process. Depending on the energy source and the configuration of the drying system, the parameters to be optimized will differ, as will be described below.…”

“…The solution/suspension is dried upon exposure to air (which can be heated or at ambient temperature), while controlling the RH of the environment. A wide range of biologicals has been processed by convective drying, including yeast, probiotics, human platelets, antibodies, restriction enzymes, and fish . Of the various processing parameters that can be controlled, the rate of drying has been reported to significantly impact recovery …”

“…These results were comparable to those reported for platelets preserved by freezing or freeze‐drying. Fellowes compared the storage stability of the virus‐neutralizing antibody of foot‐and‐mouth disease that had been air dried on paper or freeze‐dried in bottles. Air drying was accomplished by exposing the antiserum to 23°C and 30% RH for 18 h. Remarkably, the antiserum remained stable for up to 28 weeks upon storage at 37°C, and was found to be more stable than the freeze‐dried preparation.…”