For How Long Can the Liver Tolerate Ischaemia?

Kahn, D; Hickman, Rosemary; Dent, D. M.; Terblanche, J.

doi:10.1159/000128536

Cited by 32 publications

(13 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Collapsing of the bile canaliculi in this condition was never accompanied by alterations in the mi crovilli or 'terminal web', or by biliary thrombi; therefore it is probably dependent on the extremely low intensity of bile flow during warm ischemia [5]. The results ob tained here after warm ischemia agree with the finding that the pig liver tolerates this condition well for at least 120 min [11,12]. Also the rat liver tolerates warm ischemia well for at least 60 min [5], and the human liver maintains full viability for 60 min of warm ischemia [13].…”

Section: Discussionsupporting

confidence: 80%

Alterations in the Fine Structure of the Pig Liver upon Cold Ischemia

Romagnoli¹,

Rossi²,

Filipponi

et al. 1990

Eur Surg Res

View full text Add to dashboard Cite

The fine structure of the pig liver was examined after 30 min of warm ischemia at 37 °C, after 2 h of cold ischemia at 4 °C and after 30 min of warm ischemia followed by a further 30 min of cold ischemia. After warm ischemia, limited mitochondrial swelling was observed in hepatocytes. After cold ischemia, alone or following warm ischemia, vesiculation and vacuolation of the hepatocyte cytoplasm and appearance of intrasinusoidal blebs deriving from hepatocytes were observed with different intensity among the animals. These findings suggest that cooling and storing the liver at 4 °C may lead to injury, which could negatively influence the viability of the organ, with different intensity from case to case.

show abstract

Section: Discussionsupporting

confidence: 80%

Alterations in the Fine Structure of the Pig Liver upon Cold Ischemia

Romagnoli¹,

Rossi²,

Filipponi

et al. 1990

Eur Surg Res

View full text Add to dashboard Cite

show abstract

“…portacaval shunt with irreversible arterial ischaemia as described by De Groot ct al. [6] or the partial hepatectomy technique of Minato et al [ 16], The present model is theoret ically reversible because the damaged liver remains in the circulation and both insults are of a sublethal nature (the dose of CCU as described by van Leenhoff et al [25] and the arterial ischaemia chosen from the experi ence of Kahn et al [13]). In further prelimi nary studies, the administration of PGF2a rcsuted in survival in about 40% of ani mals, thus confirming the possibility of re versibility.…”

Section: Discussionmentioning

confidence: 99%

A Predictable Pathophysiological Model of Porcine Hepatic Failure

Hickman¹,

Alp²

1986

Eur Surg Res

Self Cite

View full text Add to dashboard Cite

A technique is described in which acute hepatic failure may be uniformly induced in pigs using a combination of oral phenobarbitone pretreatment and 2-hour interruption of hepatic arterial blood supply followed by intragastric carbon tetrachloride. This results in deep hepatic coma over a narrowly predictable time span and death within 12–52 h. Amino acid levels in plasma and cerebrospinal fluid obtained 24 h after the induction of hepatic failure were similar to those reported in human and experimental encephalopathy.

show abstract

“…The longer lasting Pringle manoeuvre is preferably performed in an interrupted fashion. 18 Parenchymal dissection may proceed in one of two ways: (1) with either the transparenchymal approach to vascular elements (Thon-That-Tung) 19 or (2) the preliminary dissection and control of the hilar elements of the lobe to be removed.2° Separation of the liver parenchyma is accomplished with the Kellyclamp fracture technique when the hepatic parenchyma has a normal consistency (Fig 4). Harmonic dissection is preferred when the consistency is increased as in cirrhosis.…”

Section: Anesthesiamentioning

confidence: 99%

Laparoscopic Liver Resections

Hüscher¹,

Lirici²,

Chiodini³

1998

Surgical Innovation

View full text Add to dashboard Cite

The authors present the rationale of the laparoscopic approach to liver surgery, showing the technique of fully endoscopic and endoscopic-assisted formal and wedge hepatic resections and the early results of their experience. From 1993 to 1997, 38 liver resections have been attempted through the laparoscopic or the laparoscopic assisted approach. Out of these 38 resections, 5 were wedge resections, 11 were segmentectomies, 10 were left formal hepatectomies, 1 was an extended left hepatectomy, 5 were bisegmentectomies, 5 were right formal hepatectomies, and 1 was an extended right hepatectomy. In two cases, one segmentectomy and one bisegmentectomy, the procedures were converted to open surgery. Wedge, segmental, and left liver resections were usually performed through a fully endoscopic approach, whereas right liver resections were accomplished by a video-assisted approach. In all but six cases, the resections were attempted for malignancy. There were no intra-operative deaths. One patient died on postoperative day-1 because of liver failure and severe coagulopathy. The early results are comparable to those of conventional surgery, with the benefits derived from minimal access surgery. Laparoscopic liver resections are technically feasible with an acceptable morbidity and mortality rate, but extensive experience in conventional liver surgery, advanced laparoscopic surgery, and the availability of all requested technology are indispensable prerequisites.

show abstract

For How Long Can the Liver Tolerate Ischaemia?

Cited by 32 publications

References 10 publications

Alterations in the Fine Structure of the Pig Liver upon Cold Ischemia

Alterations in the Fine Structure of the Pig Liver upon Cold Ischemia

A Predictable Pathophysiological Model of Porcine Hepatic Failure

Laparoscopic Liver Resections

Contact Info

Product

Resources

About