For Practicing Obstetricians and Gynecologists

Podzolkova, N.M.; Shamugia, N.L.; Koloda, Yu.A.; Skvortsova, M.Y.

doi:10.33029/9704-5231-8-bes-2019-1-144

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“…На сьогодні однією з основних причин ановуляторного безпліддя є синдром полікістозних яєчників (СПКЯ) для якого притаманні метаболічні розлади у вигляді ожиріння, дисліпідемії, порушення метаболізму глюкози і резистентності до інсуліну [5].…”

Section: клінічна ендокринологіяunclassified

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Arkhypkina¹,

Lyubimovа²,

Bondarenko³

et al. 2020

PEP

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The aim of the work was to study the relationship between levels of vitamin D, obesity and lipid profilein patients with polycystic ovary syndrome (PCOS).Materials and methods. The study involved 120 women: 60 patients with PCOS and 60 healthy women.All examined were divided into groups depending on body mass index (BMI): patients with PCOS — 30 withBMI ≤ 25 kg/m2and 30 with BMI ≥ 25 kg/m2; healthy women — 30 with BMI ≤ 25 kg/m2and 30 withBMI ≥ 25 kg/m2. Results. Patients with a BMI of ≥ 25 kg/m2had a lower average level of vitamin D (P < 0,001) than patientswith a BMI of ≤ 25 kg/m2; among of them there was a higher percentage of women with a pronounceddeficiency (23.3% versus 13.3%) and deficiency (60% versus 50%) of vitamin D; nobody had not adequate levelsof vitamin D. It was established a negative correlation between the level of vitamin D and BMI (r = – 0.275;P < 0.05), waist circumference (r = – 0.604; P < 0.001), the coefficient of waist circumference/ hips circumference(r = – 0.512; P < 0.001). Abdominal type of adipose tissue distribution, which was observed among patients withboth overweight and normal weight, may be one of the factors contributing to dysregulation of metabolism of vitaminD in conditions of PCOS.Women with PCOS had lipid metabolism disorders with increased atherogenic and decreased levels of antiatherogeniclipid fractions wich was intensif with increasing body weight. It was established a negative correlationbetween the level of vitamin D and triglycerides (r = – 0.437; P < 0.001), and positive association with highdensity lipoprotein cholesterol (r = 0.492; P < 0.001).In healthy women, only a negative correlation between the concentration of vitamin D and BMI (r = – 0.562;P < 0.001) was establish and there was no association with other anthropometric indicators and indicators of theblood lipid spectrum.Conclusion. Patients with PCOS have a higher prevalence and severity of deficiency of vitamin D.Disruption of regulation of vitamin D metabolism may be a consequence of existing obesity, and a decrease invitamin D levels is an additional factor that increase the dyslipidemia that exists in PCOS.

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Section: клінічна ендокринологіяunclassified