For the sake of longevity: eating less and eating at the right time

Sun, Fei; Wang, Si; Liu, Guang‐Hui

doi:10.1038/s41392-022-01163-z

Cited by 2 publications

(3 citation statements)

References 5 publications

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“…Identification of novel pro-longevity plant secondary metabolites, along with evaluation of their molecular targets, opens horizons for innovative approaches that could lead to the development of pro-longevity nutritional supplements or functional foods (Fahey & Kensler, 2021;Fontana & Partridge, 2015;V. D. Longo & Anderson, 2022;F. Sun et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…Excitingly, these advanced tools in longevity research hold promise that the first lifespan‐extending compounds could be launched in the near future. Moreover, increased interest in nutritional interventions (Fahey & Kensler, 2021; Fontana & Partridge, 2015; V. D. Longo & Anderson, 2022; F. Sun et al., 2022) draws attention to the use of plant‐derived natural compounds as an approach for achieving improved healthspan. The extensive research in the field of aging has led to the identification of several crucial pathways that regulate lifespan.…”

Section: Introductionmentioning

confidence: 99%

“…In this regard, plants are valuable sources of chemically diverse molecules with potential beneficial effects on health‐ and lifespan. Identification of novel pro‐longevity plant secondary metabolites, along with evaluation of their molecular targets, opens horizons for innovative approaches that could lead to the development of pro‐longevity nutritional supplements or functional foods (Fahey & Kensler, 2021; Fontana & Partridge, 2015; V. D. Longo & Anderson, 2022; F. Sun et al., 2022). Additionally, advancements in biological therapies such as intestinal microbiota transplantation, stem cells transplantation, gene‐editing therapy, and immunotherapy have been developed as promising options to address age‐related diseases and improve lifespan.…”

Section: Introductionmentioning

confidence: 99%

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Nurturing longevity through natural compounds: Where do we stand, and where do we go?

Todorova,

Savova,

Mihaylova

et al. 2024

Food Frontiers

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The revolution in aging research through the past decade has driven the progress in interventions that promote longevity. Dissection of the “old” hallmarks of aging has provided solid data for the definition of at least three “new” ones, opening avenues for the development of novel hallmark‐targeted pro‐longevity approaches. The quest for geroprotectors is of enormous interest with the ultimate goal of finding the alchemical stone that induces healthy aging and increases lifespan, pushing the limits of human longevity or even uncovering the absence of such limits. Several of the well‐appreciated geroprotectors that are recognized as longevity promoters are of natural origin such as metformin, resveratrol, aspirin, and spermidine. As the search for pharmacological modulators of healthspan and lifespan continues, numerous studies are focusing on the potential of plant secondary metabolites. The current review attempts to critically assess the available interventions and the breakthrough discoveries in the field of longevity research over the past decade. Correspondingly, novel approaches targeting the hallmarks of aging have been outlined, and the future goals in longevity research have been enlightened. Special emphasis has been placed on the potential of plant‐derived compounds as pro‐longevity agents.

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Section: Introductionmentioning

confidence: 99%