For whom the circadian clock ticks? Investigation of PERIOD and CLOCK gene variants in bipolar disorder

Yegin, Zeynep; Sarısoy, Gökhan; Aral, Ayse Erguner; Koç, Haydar

doi:10.1080/07420528.2021.1917594

Cited by 11 publications

(6 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors also described that PER2 rs2304672G allele frequency increased the risk for BD. Though the CLOCK gene variants analyses did not detect any differences neither in genotypes or in alleles, significant associations were found in patients in terms of clinical and behavioral patterns, including higher mean age of disease onset in the patients with GG genotypes and higher BRIAN total scores in the patients with AA [40]. In summary, these recent studies add to the emerging evidence that circadian rhythm alterations might play a key role in BD outcomes.…”

Section: Stress and Circadian Rhythm In Bipolar Disordermentioning

confidence: 68%

“…In accordance with circadian rhythm hypotheses, several studies have revealed a close link between circadian genes and BD. A recent study by Yegin et al [40] found an association between PER3 VNTR and hypomania in BD patients. Compared to the patients with PER3 4/4 repeat genotype, those with PER3 5/5 repeat genotype displayed a higher ratio of hypomania.…”

Section: Stress and Circadian Rhythm In Bipolar Disordermentioning

confidence: 90%

See 1 more Smart Citation

Advances in the pathophysiology of bipolar disorder

Wartchow

Cordeiro

Scaini

2022

Current Opinion in Psychiatry

View full text Add to dashboard Cite

Purpose of reviewDue to bipolar disorder clinical heterogeneity, a plethora of studies have provided new genetic, epigenetic, molecular, and cellular findings associated with its pathophysiology. Recent findingsGenome-wide association studies and epigenetic evidence points to genotype--phenotype interactions associated with inflammation, oxidative stress, abnormalities in signaling pathways, hypothalamic-pituitary--adrenal axis, and circadian rhythm linked to mitochondrial dysfunction in bipolar disorder. Although the literature is constantly increasing, most of the genetic variants proposed as biomarkers remain to be validated by independent groups and use bigger samples and longitudinal approaches to enhance their power and predictive ability.

show abstract

Section: Stress and Circadian Rhythm In Bipolar Disordermentioning

confidence: 68%

Section: Stress and Circadian Rhythm In Bipolar Disordermentioning

confidence: 90%

Advances in the pathophysiology of bipolar disorder

Wartchow

Cordeiro

Scaini

2022

Current Opinion in Psychiatry

View full text Add to dashboard Cite

show abstract

“…Aytac et al ( Aytac et al, 2022 ) identified an association between the VNTR variant at the rs57875989 locus of the PER3 gene and bipolar affective disorder risk, combining clinical scale assessments and blood analysis. The 4R/4R genotype appears to be protective against bipolar disorder, whereas the 5R/5R genotype is linked to a higher incidence of moderate manic symptoms in a study of 121 patients and controls ( Yegin et al, 2021 ). Additionally, a significant correlation was found between the rs228697 SNP in PER3 and increased vulnerability to sleep-wake disturbances in Alzheimer’s patients ( Lozano-Tovar et al, 2023 ).…”

Section: Brief Overview Of the Per Gene Familymentioning

confidence: 99%

Biological clock regulation by the PER gene family: a new perspective on tumor development

Chen,

Wang,

et al. 2024

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

The Period (PER) gene family is one of the core components of the circadian clock, with substantial correlations between the PER genes and cancers identified in extensive researches. Abnormal mutations in PER genes can influence cell function, metabolic activity, immunity, and therapy responses, thereby promoting the initiation and development of cancers. This ultimately results in unequal cancers progression and prognosis in patients. This leads to variable cancer progression and prognosis among patients. In-depth studies on the interactions between the PER genes and cancers can reveal novel strategies for cancer detection and treatment. In this review, we aim to provide a comprehensive overview of the latest research on the role of the PER gene family in cancer.

show abstract

“… Lee et al [ 245 ] BD: 121, Control: 121 PERIOD PER2 rs2304672 G allele frequency increased in risk for BD. Yegin et al [ 246 ] Mouse model of depression and anxiety Bmal1 Disruption of circadian rhythms by knocking down Bmal1 expression in the SCN caused depression and anxiety-like behaviors in mice. Landgraf et al [ 207 ] Mouse model of depression Cry1 The Cry1 knockout mice showed depressive-like behaviors.…”

Section: Circadian Dysfunction Mtor and MDmentioning

confidence: 99%

The trilateral interactions between mammalian target of rapamycin (mTOR) signaling, the circadian clock, and psychiatric disorders: an emerging model

2022

View full text Add to dashboard Cite

Circadian (~24 h) rhythms in physiology and behavior are evolutionarily conserved and found in almost all living organisms. The rhythms are endogenously driven by daily oscillatory activities of so-called “clock genes/proteins”, which are widely distributed throughout the mammalian brain. Mammalian (mechanistic) target of rapamycin (mTOR) signaling is a fundamental intracellular signal transduction cascade that controls important neuronal processes including neurodevelopment, synaptic plasticity, metabolism, and aging. Dysregulation of the mTOR pathway is associated with psychiatric disorders including autism spectrum disorders (ASD) and mood disorders (MD), in which patients often exhibit disrupted daily physiological rhythms and abnormal circadian gene expression in the brain. Recent work has found that the activities of mTOR signaling are temporally controlled by the circadian clock and exhibit robust circadian oscillations in multiple systems. In the meantime, mTOR signaling regulates fundamental properties of the central and peripheral circadian clocks, including period length, entrainment, and synchronization. Whereas the underlying mechanisms remain to be fully elucidated, increasing clinical and preclinical evidence support significant crosstalk between mTOR signaling, the circadian clock, and psychiatric disorders. Here, we review recent progress in understanding the trilateral interactions and propose an “interaction triangle” model between mTOR signaling, the circadian clock, and psychiatric disorders (focusing on ASD and MD).

show abstract

For whom the circadian clock ticks? Investigation of PERIOD and CLOCK gene variants in bipolar disorder

Cited by 11 publications

References 41 publications

Advances in the pathophysiology of bipolar disorder

Advances in the pathophysiology of bipolar disorder

Biological clock regulation by the PER gene family: a new perspective on tumor development

The trilateral interactions between mammalian target of rapamycin (mTOR) signaling, the circadian clock, and psychiatric disorders: an emerging model

Contact Info

Product

Resources

About