The paper studies the productivity of winter durum wheat of Zolotko variety subject to the treatment of seed grains with the preparations Poly-Feed, Plodorodiye Sibiri, Vitazim, Agat-25K, Micromak, potassium humate applied separately and in the mixture of Poly-Feed + Plodorodiye Sibiri + Vitazim followed by the treatment of plants with Vitazim, Fertigrain Foliar and the mixture of Vitazim + Fertigrain Foliar in the forest-steppe of the Central Chernozem Region. The experiments were conducted in 2014/15-2015/16 in the fields of Voronezh SAU. For the treatment of winter durum wheat seeds, the most effective preparations to increase tillering capacity were Agat-25K (1.18 seeds/plant), Vitazim (1.17 seeds/plant) and potassium humate (1.17 seeds/plant). The number of kernels per head increased provided that the seeds were treated with Agat-25K, Micromak, Plodorodiye Sibiri, especially followed by the further treatment of plants with the mixture of Vitazim + Fertigrain Foliar. The weight of grains in the ear increased up to 1.28 and 1.27g when the seeds were treated with Agat-25K and Micromak jointly with the treatment of plants with Vitazim + Fertigran Foliar. A thousand grain weight was greater when the seeds were treated with Agat 25K, Micromak and potassium humate jointly with the treatment of plants with a mixture of Vitazim + Fertigrean Foliar and amounted to 45.0; 44.9 and 44.85g, respectively. A high yield was obtained when Agat-25K and Micromak were used for treating seeds, together with treating plants with a mixture of Vitazim + Fertigrean Foliar. It amounted to 52.7 and 52.2 c/ha, respectively. The highest synergetic efficiency was observed when treating the seeds with Agat-25K or Micromak together with treating the plants with Vitazim + Fertigrain Foliar mixture.