Scoliosis is a condition that affects the spine and causes chest rotation and trunk distortion. Individuals with severe deformities may experience dyspnea on exertion and develop respiratory failure. Respiratory oscillometry is a simple and non-invasive method that provides detailed information on lung mechanics. This work aims to investigate the potential of oscillometry in the evaluation of respiratory mechanics in patients with scoliosis and its association with physical performance. We analyzed 32 volunteers in the control group and 32 in the scoliosis group. The volunteers underwent traditional pulmonary function tests, oscillometry, and the 6-minute walk test (6MWT). Oscillometric analysis showed increased values of resistance at 4 Hz (R4, Po0.01), 12 Hz (R12, Po0.0001), and 20 Hz (R20, Po0.01). Similar analysis showed reductions in dynamic compliance (Cdyn, Po0.001) and ventilation homogeneity, as evaluated by resonance frequency (fr, Po0.001) and reactance area (Ax, Po0.001). Respiratory work, described by the impedance modulus, also showed increased values (Z4, Po0.01). Functional capacity was reduced in the group with scoliosis (Po0.001). A significant direct correlation was found between Cobb angle and R12, AX, and Z4 (P=0.0237, P=0.0338, and P=0.0147, respectively), and an inverse correlation was found between Cdyn and Cobb angle (P=0.0190). These results provided new information on respiratory mechanics in scoliosis and are consistent with the involved pathophysiology, suggesting that oscillometry may improve lung function tests for patients with scoliosis.