Forearm bone-anchored amputation prosthesis: A case study on the osseointegration

Palmquist, Anders; Jarmar, Tobias; Emanuelsson, Lena; Brånemark, Rickard; Engqvist, Håkan; Thomsen, Peter

doi:10.1080/17453670710014806

Cited by 41 publications

(36 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been postulated that the difficulties associated with FIB techniques on smoother implant interfaces is probably partly due to volume reduction of the tissue, related to fixation and dehydration, and partly due to minimal biomechanical integration needed to withstand tensions at the immediate interface. However, a small amount of biological tissue is always present at the immediate interface of FIB-produced specimens [5,13], confirming a preparation artefact rather than a lack of osseointegration on the nano-level. For the laser-modified surface, intact samples could be readily prepared by FIB, and showed an intimate contact between the surface oxide and bone tissue using TEM.…”

Section: Discussionmentioning

confidence: 99%

Bone–titanium oxide interface in humans revealed by transmission electron microscopy and electron tomography

Palmquist

Grandfield

Norlindh

et al. 2011

J. R. Soc. Interface.

Self Cite

View full text Add to dashboard Cite

Osseointegration, the direct contact between an implant surface and bone tissue, plays a critical role in interfacial stability and implant success. Analysis of interfacial zones at the micro- and nano-levels is essential to determine the extent of osseointegration. In this paper, a series of state-of-the-art microscopy techniques are used on laser-modified implants retrieved from humans. Partially laser-modified implants were retrieved after two and a half months' healing and processed for light and electron microscopy. Light microscopy showed osseointegration, with bone tissue growing both towards and away from the implant surface. Transmission electron microscopy revealed an intimate contact between mineralized bone and the laser-modified surface, including bone growth into the nano-structured oxide. This novel observation was verified by three-dimensional Z-contrast electron tomography, enabling visualization of an apatite layer, with different crystal direction compared with the apatite in the bone tissue, encompassing the nano-structured oxide. In conclusion, the present study demonstrates the nano-scale osseointegration and bonding between apatite and surface-textured titanium oxide. These observations provide novel data in human specimens on the ultrastructure of the titanium–bone interface.

show abstract

Section: Discussionmentioning

confidence: 99%

Bone–titanium oxide interface in humans revealed by transmission electron microscopy and electron tomography

Palmquist

Grandfield

Norlindh

et al. 2011

J. R. Soc. Interface.

Self Cite

View full text Add to dashboard Cite

show abstract

“…We believe that this perception might be true in the short term. Long-term effects must be considered, since DSA is intended for lifelong use and present reports on the long-term applications of the DSA are still limited [86]. …”

Section: Bone-implant Interfacementioning

confidence: 99%

Untitled

Pitkin

2009

JRRD

View full text Add to dashboard Cite

Two decades after introducing threaded titanium dental implants, Dr. Per-Ingvar Brånemark used a similar technique in the 1980s to pioneer the direct skeletal attachment (DSA) of limb prostheses. He and his colleagues used convincing clinical experience to overcome the skepticism of their peers, affording a new dimension of prosthetic rehabilitation to almost 100 individuals with amputation. As a result, more research has been initiated worldwide to move DSA to a level of greater safety, longevity, and reliability. This review highlights the trends and milestones in current DSA development. It also identifies ideas from previous studies in various fields that may be useful in future DSA development.

show abstract

“…The structure of the intact bone/titanium interface is now well characterized down to the nanoscale (Palmquist et al 2008(Palmquist et al , 2009(Palmquist et al , 2010. However, the early cellular and molecular activities determining the early tissue response and bone formation at the bone/ implant interface are not yet fully understood.…”

Section: Cell and Molecular Biologymentioning

confidence: 99%

“…These interposed layers could either be electron dense (Steflik et al 1999) or electron lucent (Albrektsson et al 1985) and sometimes referred to as a cement-like line (Davies 2007). With the use of FIB for sample preparation where an intact interface could be analysed as both implant and tissue are present in the sample, it has recently been shown that the interface is mineralized both for machined (Palmquist et al 2008) and laser modified implants (Palmquist et al 2010). Further, it has also been demonstrated that the bonding mechanisms are different between different implant surfaces where micro-and nanostructured laser-modified implant surfaces attain a strong bonding at the nano-level (figure 3).…”

Section: Ultrastructurementioning

confidence: 99%

Titanium oral implants: surface characteristics, interface biology and clinical outcome

Palmquist

Omar

Esposito

et al. 2010

J. R. Soc. Interface.

Self Cite

213

192

View full text Add to dashboard Cite

Bone-anchored titanium implants have revolutionized oral healthcare. Surface properties of oral titanium implants play decisive roles for molecular interactions, cellular response and bone regeneration. Nevertheless, the role of specific surface properties, such as chemical and phase composition and nanoscale features, for the biological in vivo performance remains to be established. Partly, this is due to limited transfer of state-of-the-art preparation techniques to complex three-dimensional geometries, analytical tools and access to minute, intact interfacial layers. As judged by the available results of a few randomized clinical trials, there is no evidence that any particular type of oral implant has superior long-term success. Important insights into the recruitment of mesenchymal stem cells, cell -cell communication at the interface and high-resolution imaging of the interface between the surface oxide and the biological host are prerequisites for the understanding of the mechanisms of osseointegration. Strategies for development of the next generation of material surface modifications for compromised tissue are likely to include time and functionally programmed properties, pharmacological modulation and incorporation of cellular components.

show abstract

Forearm bone-anchored amputation prosthesis: A case study on the osseointegration

Cited by 41 publications

References 14 publications

Bone–titanium oxide interface in humans revealed by transmission electron microscopy and electron tomography

Bone–titanium oxide interface in humans revealed by transmission electron microscopy and electron tomography

Untitled

Titanium oral implants: surface characteristics, interface biology and clinical outcome

Contact Info

Product

Resources

About