Foreign Bodies Associated With Peri‐Implantitis Human Biopsies

Wilson, Thomas G.; Valderrama, Pilar; Burbano, Maria; Blansett, Jonathan; Levine, Robert A.; Kessler, Harvey P.; Rodrigues, Danieli C.

doi:10.1902/jop.2014.140363

Cited by 183 publications

(195 citation statements)

References 33 publications

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“…Some authors stated that implant osseointegration is not simply a wound healing phenomenon but rather complex foreign body reaction with activation of the immune system [56]. Titanium and metal particle release is discussed as cause for implant failure as well as implant dentistry [5, 6, 9, 56, 57]. It is assumed that metal particles influence the macrophage or lymphocyte pathways and provoke a release of pro-inflammatory cytokines, leading to an increased osteoclastogenesis and decreased osteoblastogenesis and consequently to peri-implant bone loss [58].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency in early implant failure: two case reports

et al. 2016

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An association between vitamin D deficiency and early dental implant failure is not properly verified, but its role in osteoimmunology is discussed. This article illustrates two case reports with vitamin D deficiency and early implant failure. Prior to implant placement, the first patient received crestal bone grafting with autologous material. Both patients received dental implants from different manufacturers in the molar region of the mandible. In the case of bone grafting in the first patient, all implants were placed in a two-stage procedure. All implants had to be removed within 15 days after implant placement. Vitamin D serum levels were measured: Both patients showed a vitamin D deficiency (serum vitamin D level <20 μg/l). After vitamin D supplementation, implant placement was successful in both patients. Prospective, randomized clinical trials must follow to affirm the relationship between vitamin D deficiency, osteoimmunology, and early implant failure.

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Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency in early implant failure: two case reports

et al. 2016

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“…Wear debris depositing in surrounding tissues can induce an inflammatory response if debris remain in the implantation site [21][22][23]. It was hypothesized that insertion forces could induce premature breakage of the titanium oxide layer, resulting in particle debris generation.…”

Section: Discussionmentioning

confidence: 99%

“…There is an increasing prevalence of this clinical condition leading to failure of DI [15]. The accumulation of titanium particles and ions in tissues surrounding implants has been reported in the literature [22,23]. The accumulation of titanium particles and ions in tissues surrounding implants has been reported in the literature [22,23].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Evaluation of Titanium Exfoliation During Simulated Surgical Insertion of Dental Implants

Sridhar

Wilson²,

Valderrama³

et al. 2016

Journal of Oral Implantology

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Dissolution of titanium wear particles in the oral environment, and their accumulation in the surrounding tissues have been associated with failure of dental implants (DI). The goal of this study is to investigate the effect of mechanical forces involved in surgical insertion of DI on surface wear and metal particle generation. It was hypothesized that mechanical factors associated with implant placement can lead to the generation of titanium particles in the oral environment. The testing methodology for surface evaluation employed simulated surgical insertion, followed by removal of DI in different densities of simulated bone material. Torsional forces were monitored for the insertion and removal of DI. The surface of the simulated bone materials was inspected with optical microscopy to detect traces of metallic particles that may have been generated during the procedure. Further characterization of the composition of powders collected from osteotomy cavities was conducted with powder X-ray diffraction. The results showed that the different densities of simulated bone material affected the torsional forces associated with implant insertion. However, the mechanical factors involved in the implant insertion/removal procedure did not generate wear particles, as confirmed by powder X-ray experiments.

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“…In the research conducted by Wilson et al, [16] the microscopic analysis of soft tissue biopsies taken from around dental implants with cemented restorations suffering from peri-implantitis revealed a mixture of subacute and chronic inflammation immunologic factors, dominated by plasma cells. Foreign bodies primarily consisting of titanium and dental cement were found to be associated with an inflammatory infiltrate.…”

Section: Resultsmentioning

confidence: 99%

“…Anyway, further studies need to be done until the accuracy of this hypothesis is proved. [16] Bruno et al [17] hypothesized that due to corrosion, the dental titanium implant's surface can be a potential source of the release of microsized particles (MPs) and nanosized particles (NPs) into the body's biological environment. This work sought to evaluate the biokinetics of different sized titanium dioxide particles (TiO 2 ) and their potential to cause organ's cell damage.…”

Section: Resultsmentioning

confidence: 99%

Histopathological evaluation of gingival tissue overlying two-stage implants after placement of cover screws

Paknejad

Bayani

Yaghobee

et al. 2015

Biotechnology & Biotechnological Equipment

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Corrosion of implant components, including that of cover screws, has been reported as a possible etiological factor for implant failure. This study evaluated the presence of metallic particles in the soft tissues overlying two-stage implants after placing cover screws, by using a histological technique and energy-dispersive X-ray spectroscopy. The results showed large and small titanium particles in different layers of the soft tissue overlying the implant and cover screws in the majority of samples, with more particles near the cover screws. These particles might have contributed to the various degrees of inflammatory reactions detected in the different layers of the overlying soft tissues. Further studies on the corrosion of implants' metallic components are recommended, so that the implant failure rates could be minimized.

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Foreign Bodies Associated With Peri‐Implantitis Human Biopsies

Abstract: At present, the exact mechanism for introduction of these materials and their role in peri-implantitis is unknown. Further research is warranted to determine their etiology and potential role in pathogenesis.

Cited by 183 publications

References 33 publications

Vitamin D deficiency in early implant failure: two case reports

Vitamin D deficiency in early implant failure: two case reports

In Vitro Evaluation of Titanium Exfoliation During Simulated Surgical Insertion of Dental Implants

Histopathological evaluation of gingival tissue overlying two-stage implants after placement of cover screws

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