Foreign Body Response

Hunt, John A.

doi:10.1201/b18990-109

Cited by 4 publications

(5 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These specific reactions are called thrombotic and thromboembolic complications. To study hemocompatibility is related to the study of the thrombogenic behavior of a material; a material with low thrombogenicity will be therefore more hemocompatible and will also reduce the risk of bleeding associated with the use of blood thinners[45] [46] [40]. To date a man-made material that is purely hemocompatible has not been reported, and the mechanisms behind surface-blood interactions have not been completely understood.…”

mentioning

confidence: 99%

Hemocompatibility Assessment of 3C-SiC for Cardiovascular Applications

Schettini

2012

Silicon Carbide Biotechnology

View full text Add to dashboard Cite

mentioning

confidence: 99%

Hemocompatibility Assessment of 3C-SiC for Cardiovascular Applications

Schettini

2012

Silicon Carbide Biotechnology

View full text Add to dashboard Cite

“…This matrix provides the structural, cellular and biochemical cues for either the wound healing process or the foreign body reaction (FBR). These reactions are for the most part identical, but distinguished by the presence of a foreign body [ 50 ]. Anderson et al ., provides a thorough overview of foreign body reactions to biomaterials [ 51 ].…”

Section: Biocompatibilitymentioning

confidence: 99%

Biodegradable Polymers in Bone Tissue Engineering

et al. 2009

View full text Add to dashboard Cite

The use of degradable polymers in medicine largely started around the mid 20th century with their initial use as in vivo resorbing sutures. Thorough knowledge on this topic as been gained since then and the potential applications for these polymers were, and still are, rapidly expanding. After improving the properties of lactic acid-based polymers, these were no longer studied only from a scientific point of view, but also for their use in bone surgery in the 1990s. Unfortunately, after implanting these polymers, different foreign body reactions ranging from the presence of white blood cells to sterile sinuses with resorption of the original tissue were observed. This led to the misconception that degradable polymers would, in all cases, lead to inflammation and/or osteolysis at the implantation site. Nowadays, we have accumulated substantial knowledge on the issue of biocompatibility of biodegradable polymers and are able to tailor these polymers for specific applications and thereby strongly reduce the occurrence of adverse tissue reactions. However, the major issue of biofunctionality, when mechanical adaptation is taken into account, has hitherto been largely unrecognized. A thorough understanding of how to improve the biofunctionality, comprising biomechanical stability, but also visualization and sterilization of the material, together with the avoidance of fibrotic tissue formation and foreign body reactions, may greatly enhance the applicability and safety of degradable polymers in a wide area of tissue engineering applications. This review will address our current understanding of these biofunctionality factors, and will subsequently discuss the pitfalls remaining and potential solutions to solve these problems.

show abstract

“…The use of bioactive materials, in this case bioactive ceramics, glass-ceramics and glasses, pursues an interfacial direct bond between the material and the bone avoiding the formation of a fibrous tissue capsule around the implant [41]. The intimate contact of bone to biomaterial depends not only on the material properties but also on the response of the host.…”

Section: Figure 1 Stages In Bone Healingmentioning

confidence: 99%

Bioactive Composites Based on Calcium Phosphates for Bone Regeneration

Navarro

Planell

2010

KEM

View full text Add to dashboard Cite

Bone problems affect millions of people across the world. In fact, musculoskeletal conditions such as joint pathologies, fractures related to osteoporosis, back pain, serious injuries and different sorts of bone diseases and disabilities are among the most common causes for hundreds of millions of people worldwide suffering acute and severe long-term pain and becoming physically handicapped. It has been reported that over 100 million Europeans are affected by different bone related problems and suffer chronic musculoskeletal pain, while in the US musculoskeletal problems affect over 40 million people aged 45 years and older. It is expected that the percentage of population affected by musculoskeletal conditions will double by the year 2020. Although morbidity is low, they have a major effect on disability, medical costs and patient quality of life [1,2]. Thus, bone defect treatments represent a significant medical and socioeconomic challenge.

show abstract

Foreign Body Response

Cited by 4 publications

References 14 publications

Hemocompatibility Assessment of 3C-SiC for Cardiovascular Applications

Hemocompatibility Assessment of 3C-SiC for Cardiovascular Applications

Biodegradable Polymers in Bone Tissue Engineering

Bioactive Composites Based on Calcium Phosphates for Bone Regeneration

Contact Info

Product

Resources

About